Volume 5.10 | Mar 17

Pulmonary Cell News 5.10 March 17, 2016
Pulmonary Cell News
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Drug Combination Shuts Down Cancer Stem Cells and Tumor Growth in Aggressive Lung Cancer
Researchers have shut down one of the most common and lethal forms of lung cancer by combining the rheumatoid arthritis drug auranofin with an experimental targeted agent. The combination therapy worked in a laboratory study to stop lung adenocarcinoma associated with mutation of the KRAS gene. [Press release from Mayo Clinic discussing online prepublication in Cancer Cell] Press Release | Abstract
Watch Now: Webinar on Gastrointestinal Organoids by Dr. Meritxell Huch
PUBLICATIONS (Ranked by impact factor of the journal)
Moraxella catarrhalis Decreases Antiviral Innate Immune Responses by Down-Regulation of TLR3 via Inhibition of p53 in Human Bronchial Epithelial Cells
M. catarrhalis induces a significant down-regulation of TLR3 in human bronchial epithelial cells. In M. catarrhalis-infected cells, expression of p53 was decreased. [FASEB J] Abstract

Oxidized Ferric and Ferryl Forms of Hemoglobin Trigger Mitochondrial Dysfunction and Injury in Alveolar Type I Cells
Using mouse E10 cells as an alveolar type I cell cell model, scientists demonstrated that higher hemoglobin (Hb) oxidation states ferric and ferryl Hb and subsequent heme loss play a central role in the genesis of injury. [Am J Respir Cell Mol Biol] Abstract

β1-Na+,K+-ATPase Gene Therapy Upregulates Tight Junctions to Rescue Lipopolysaccharide-Induced Acute Lung Injury
Gene transfer of β1-Na+,K+-ATPase, but not α1-subunit of epithelial sodium channel, not only enhanced expression of tight junction protein zona occludins-1 and occludin both in cultured cells and in mouse lungs, but also reduced pre-existing increase of lung permeability in vivo. [Gene Ther] Abstract

Dipeptidyl Peptidase-4 Is Highly Expressed in Bronchial Epithelial Cells of Untreated Asthma and It Increases Cell Proliferation along with Fibronectin Production in Airway Constitutive Cells
Researchers investigated the expression of dipeptidyl peptidase-4 in the asthmatic airway, and its role in the pathophysiology of asthma. [Respir Res] Full Article

Human H7N9 Virus Induces a More Pronounced Pro-Inflammatory Cytokine but an Attenuated Interferon Response in Human Bronchial Epithelial Cells when Compared with an Epidemiologically-Linked Chicken H7N9 Virus
The authors previously isolated an H7N9 virus from a patient, and an H7N9 virus from a chicken in a live poultry market where the patient visited during the incubation period. These two viruses were genetically highly similar. This study sought to use a human bronchial epithelial cell line model to infer the virulence of these H7N9 viruses in humans. [Virol J] Full Article


APR-246 (PRIMA-1MET) Strongly Synergizes with AZD2281 (Olaparib) Induced PARP Inhibition to Induce Apoptosis in Non-Small Cell Lung Cancer Cell Lines
Scientists observed that APR-246 synergistically enhanced the cytotoxic response of olaparib in TP53 mutant non-small cell lung cancer cell lines, resulting in a strong apoptotic response. [Cancer Lett] Abstract

Overexpression of miR-499-5p Inhibits Non-Small Cell Lung Cancer Proliferation and Metastasis by Targeting VAV3
Researchers demonstrated that miR-499-5p was significantly reduced in NSCLC tissues and correlated with poor clinical outcomes. Overexpression of miR-499-5p inhibited cell proliferation and induced apoptosis in vitro and in vivo. [Sci Rep] Full Article

hnRNPK Inhibits GSK3β Ser9 Phosphorylation, Thereby Stabilizing c-FLIP and Contributes to TRAIL Resistance in H1299 Lung Adenocarcinoma Cells
Investigators showed that, when H1299 lung adenocarcinoma cells were treated with TRAIL, hnRNPK is translocated from nucleus to cytoplasm where it interacts and co-localizes with GSK3β. [Sci Rep] Full Article

Periostin Contributes to Cisplatin Resistance in Human Non-Small Cell Lung Cancer A549 Cells via Activation of Stat3 and Akt and Upregulation of Survivin
Periostin was significantly upregulated in cisplatin (CDDP)-resistant A549 cells, compared to parental controls. Overexpression of periostin rendered A549 cells more resistant to CDDP-induced apoptosis and enhanced Stat3 and Akt phosphorylation and survivin expression. [Cell Physiol Biochem] Full Article

Learn More: Model the Human Airway at the Air-Liquid Interface
Manipulating Proteostasis to Repair the F508del-CFTR Defect in Cystic Fibrosis
The authors discuss how the therapeutic normalization of defective proteostasis can be harnessed for the treatment of cystic fibrosis patients with the F508del-cystic fibrosis transmembrane conductance regulator (CFTR) mutation. [Mol Cell Pediatr] Full Article

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
XALKORI® (Crizotinib) Approved by U.S. FDA for the Treatment of Patients with ROS1-Positive Metastatic Non-Small Cell Lung Cancer
Pfizer Inc. announced that the U.S. Food and Drug Administration (FDA) has approved a supplemental New Drug Application for XALKORI® to treat patients with metastatic non-small cell lung cancer whose tumors are ROS1-positive. [Pfizer Inc.] Press Release

Aradigm Announces Decision for Centralized Review of Pulmaquin by the European Medicines Agency
Aradigm Corporation announced that the European Medicines Agency has approved its request to review Pulmaquin®, Aradigm’s investigational inhaled liposomal ciprofloxacin product, under the Centralised Authorisation Procedure drug review process. [Aradigm Corporation] Press Release

SRI International Receives $19.8 Million National Cancer Institute Contract for PREVENT Cancer Program
SRI International has been awarded a contract of up to $19.8 million from the National Cancer Institute PREVENT Cancer Preclinical Drug Development Program to support the development of potential cancer preventive agents or vaccines. [SRI International] Press Release

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National Institutes of Health (United States)

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

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Therapeutic Goods Administration (Australia)
NEW International Society for Cellular Therapy (ISCT) 2016
May 25-28, 2016
Singapore, Singapore

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Postdoctoral Positions – Tissue Repair/Inflammation (Institut Pasteur)

Postdoctoral Position or Research Scientist – Mucosal Immunology (Qu Biologics)

Faculty Positions – Cancer Research (Texas Tech University Health Sciences Center)

Postdoctoral Fellow – Lung Cancer (The University of Texas MD Anderson Cancer Center)

Associate or Full Professor – Cardiothoracic Surgery (University of California San Diego)

Postdoctoral Research Fellow – Lung Cancer (Cornell University)

Postdoctoral Fellow – Lung Cancer Research (German Cancer Research Center)

Project Scientist – Pulmonary Fibrosis (Cedars Sinai Medical Center)

Postdoctoral Fellow – Bioinformatics RNA Biology & Cancer (German Cancer Research Center)

Director Clinical Research – Medical Oncology (Fred Hutchinson Cancer Research Center)

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