Volume 4.37 | Sep 24

Pulmonary Cell News 4.37 September 24, 2015
Pulmonary Cell News
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SLUG Is Required for SOX9 Stabilization and Functions to Promote Cancer Stem Cells and Metastasis in Human Lung Carcinoma
Inhibition of either SLUG or SOX9 sufficiently inhibits cancer stem cells in human lung cancer cells and attenuates experimental lung metastasis in a xenograft mouse model. Correlation between SLUG and SOX9 levels was observed, so the authors explored their mechanistic relationship and regulation. [Oncogene] Abstract
Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
PUBLICATIONS (Ranked by impact factor of the journal)
Contribution of Alveolar Type II Cell–Derived Cyclooxygenase-2 to Basal Airway Function, Lung Inflammation, and Lung Fibrosis
Researchers generated mice with alveolar type II (ATII) cell–specific knockdown of COX-2, to examine the role of ATII cell–derived prostaglandins in these processes. [FASEB J] Abstract

Differential Susceptibility of Human Lung Primary Cells to H1N1 Influenza Viruses
Investigators report that alveolar epithelial cells (AECs) are the direct targets for H1N1 viruses that have circulated since the 2009 pandemic (H1N1pdm09). Alveolar macrophages are less susceptible to H1N1pdm09 virus, but they produce significantly more inflammatory cytokines than AECs from the same donor. [J Virol] Abstract

Basal Cells of the Human Airways Acquire Mesenchymal Traits in Idiopathic Pulmonary Fibrosis and in Culture
To determine if p63-positive basal cells were able to undergo epithelial-to-mesenchymal transition in culture, scientists treated VA10, a p63-positive basal cell line, with the serum replacement UltroserG. A sub-population of treated cells acquired a mesenchymal phenotype, including an E- to N-cadherin switch. [Lab Invest] Abstract

Amelioration of Particulate Matter-Induced Oxidative Damage by Vitamin C and Quercetin in Human Bronchial Epithelial Cells
The authors indicated that fine particulate matter depleted the cell viability of 16HBE cells, elevated reactive oxygen species generation, and inhibited mitochondrial genes expressions, including fusion proteins Mfn1 and OPA1, along with biogenesis markers SIRT1 and p53R2. [Chemosphere] Abstract

Transcriptomic Analyses of the Biological Effects of Airborne PM2.5 Exposure on Human Bronchial Epithelial Cells
In order to investigate the mechanisms of air pollution-induced lung toxicity in humans, human bronchial epithelial cells were exposed to various concentrations of particles smaller than 2.5 μm (PM2.5) collected from Beijing, China. [PLoS One] Full Article


Down-Regulation of MicroRNA-144 in Air Pollution-Related Lung Cancer
MicroRNA (miR)-144 interacted with the oncogene Zeb1 at 2 sites in its 3′ untranslated region, and a decrease in miR-144 resulted in increased Zeb1 expression and an epithelial mesenchymal transition phenotype. Ectopic expression of miR-144 suppressed non-small cell lung cancers in vitro and in vivo by targeting Zeb1. [Sci Rep] Full Article

BMP4 Depletion by miR-200 Inhibits Tumorigenesis and Metastasis of Lung Adenocarcinoma Cells
The authors investigated the mechanism and role of bone morphogenetic protein 4 (BMP4) depletion by microRNA-200 (miR-200) in murine lung adenocarcinoma cells. [Mol Cancer] Full Article

HEPACAM Inhibited the Growth and Migration of Cancer Cells in the Progression of Non-Small Cell Lung Cancer
Scientists found that the expression of hepatocyte cell adhesion molecule (HEPACAM) was downregulated in non-small cell lung cancer (NSCLC) tissues. Forced expression of HEPACAM in NSCLC cells inhibited the growth and migration of the cancer cells, while knocking down the expression of HEPACAM promoted cell growth, migration, and metastasis. [Tumor Biol] Abstract

Learn More: Model the Human Airway at the Air-Liquid Interface
Histone Modifications and Asthma – The Interface of the Epigenetic and Genetic Landscapes
The authors look beyond the biological information coded by DNA, and review the epigenetic modifications made to histones, with evidence suggesting a role for their modification in asthma. [Am J Respir Cell Mol Biol] Abstract

The Emerging Roles of β-Arrestins in Fibrotic Diseases
The authors survey the involvement of β-arrestins in various signaling pathways and highlight different aspects of their regulation of fibrosis. They also discuss the important roles of β-arrestins in the process of fibrotic diseases by regulating the inflammation and deposit of extracellular matrix. [Acta Pharmacol Sin] Full Article

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
Melinta Therapeutics Demonstrates Potency of Delafloxacin against Bacteria Associated with Respiratory Tract Infections
Melinta Therapeutics announced in vitro results demonstrating delafloxacin’s activity against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. [Press release from Melinta Therapeutics, Inc. (Globe Newswire) discussing research presented at the 55th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Diego] Press Release

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Boehringer Ingelheim and BioMed X Apply Crowdsourcing to Establish a Team of Scientists for Identifying Key Epigenetic Regulators of COPD
Boehringer Ingelheim and BioMed X announced that they have successfully applied a crowdsourcing approach to establish a research team of outstanding scientists from around the world with bright ideas, who will endeavor to identify new approaches for the treatment of patients with chronic obstructive pulmonary disease (COPD). [Boehringer Ingelheim GmbH] Press Release

Aradigm Corporation Completes Enrollment in Phase III Study of Pulmaquin in Non-Cystic Fibrosis Bronchiectasis (ORBIT-4)
Aradigm Corporation announced the completion of enrollment in the ORBIT-4 Phase III pivotal clinical trial of Pulmaquin®, Aradigm’s proprietary investigational formulation of inhaled ciprofloxacin, for the treatment of patients with non-cystic fibrosis bronchiectasis who have chronic lung infections with Pseudomonas aeruginosa. [Aradigm Corporation] Press Release
Canadian Election Spotlights Scientists’ Frustrations
Canadians will head to the polls on October 19th, in a federal election that many scientists hope will mark a turning point after years of declining research budgets and allegations of government censorship. Although science has not emerged as a top issue during the campaign, researchers are fighting to make their concerns heard. [Nature News] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 2nd Matrix Biology Ireland (MBI) 2015
December 2-4, 2015
Dublin, Ireland

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Postdoctoral Fellowships – Chronic Heart or Lung Disease (University of British Columbia)

Postdoctoral Fellow – Asthma (The University of Tennessee Health Science Center)

Postdoctoral Scholar – Autoimmune Diseases Affecting the Lung (University of California, San Francisco)

Postdoctoral Researcher – Epigenetic Modifiers (Van Andel Research Institute)

Postdoctoral Research Fellow – Small Cell Lung Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Lung Cancer (Van Andel Research Institute)

Postdoctoral Fellow – Pulmonary Biology (The University of Alabama)

Postdoctoral Research Fellow – Cancer and Molecular Imaging (University of Michigan)

Postdoctoral Fellow – HMGA Chromatin Remodeling Proteins in Cancer and Stem Cell Biology (Johns Hopkins University School of Medicine)

Postdoctoral Research Associate – Airway Diseases (GlaxoSmithKline)

Postdoctoral Fellow – Pulmonary Fibrosis (University of Colorado School of Medicine)

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