Volume 4.17 | May 7

Pulmonary Cell News 4.17 May 7, 2015
Pulmonary Cell News
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Scientists Identify Key Regulator of Non-Small Cell Lung Cancer Plasticity and Therapeutic Response
Scientists revealed differential reactive oxygen species (ROS) levels in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) of a KrasG12D;Lkb1lox/lox mouse model. They found that ROS can modulate ADC-to-SCC transdifferentiation. [Press release from the Chinese Academy of Sciences discussing online prepublication in Cancer Cell] Press Release | Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Preclinical Validation and Imaging of Wnt-Induced Repair in Human 3D Lung Tissue Cultures
Inducing repair processes within the adult diseased lung is of major interest and Wnt/β-catenin signaling represents a promising target for lung repair. Scientists generated murine and patient-derived three-dimensional (3D) ex vivo lung tissue cultures, which closely mimic the 3D lung microenvironment in vivo. [Eur Respir J] Abstract | Press Release

Is the Cellular Uptake of Respiratory Aerosols Delivered from Different Devices Equivalent?
Deposition and transport profiles of three different inhaled salbutamol sulphate formulations with clinically relevant doses were evaluated using a modified Andersen Cascade Impactor coupled with the air interface Calu-3 bronchial cell model. [Eur J Pharm Biopharm] Abstract

Motile Cilia Harbor Serum Response Factor as a Mechanism of Environment Sensing and Injury Response in the Airway
Using a mouse model of organic dust-induced airway inflammation, researchers found that the transcription factor serum response factor localizes to motile cilia of airway epithelial cells and alters its localization in response to inflammatory stimuli. [Am J Physiol Lung Cell Mol Physiol] Full Article

Plasminogen Activator Inhibitor-1 in Cigarette Smoke Exposure and Influenza A Virus Infection-Induced Lung Injury
Investigators found increased p53, PAI-1 and apoptosis in alveolar epithelial cells, with accumulation of macrophages and neutrophils in the lungs of patients with chronic obstructive pulmonary disease. [PLoS One] Full Article


Activated Cdc42-Associated Kinase Is Up-Regulated in Non-Small-Cell Lung Cancer and Necessary for FGFR-Mediated AKT Activation
Scientists found that the expression of activated cdc42-associated tyrosine kinase 1 (ACK1) was significantly up-regulated in non-small-cell lung cancer (NSCLC) samples compared to their adjacent normal tissues. ACK1 was further validated to promote the growth, migration, and metastasis of NSCLC cells in vitro and in vivo. [Mol Carcinog] Abstract

Immunomodulatory Protein from Ganoderma microsporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells
Researchers examined the roles of autophagy in the death of multidrug resistant (MDR) A549 lung cancer sublines by a fungal protein from G. microsporum, thapsigargin (TG) and tunicamycin (TM) in vitro. Cytotoxicity of TG was inhibited by overexpressed p-glycoprotein (P-gp). However, TM-induced death of MDR sublines was independent of P-gp level. [PLoS One] Full Article

Nonsense and Missense Mutation of Mitochondrial ND6 Gene Promotes Cell Migration and Invasion in Human Lung Adenocarcinoma
The authors investigated the possible role of mitochondrial ND6 (mitND6) gene nonsense and missense mutations in the metastasis of human lung adenocarcinoma. They studied the effects of mitND6 gene nonsense and missense mutations on cell migration and invasion through wounding healing and matrigel-coated transwell assay. [BMC Cancer] Abstract | Full Article

NBM-T-BBX-OS01, Semisynthesized from Osthole, Induced G1 Growth Arrest through HDAC6 Inhibition in Lung Cancer Cells
Investigators demonstrated the effects of semisynthesized NBM-T-BBX-OS01 from osthole on histone deacetylase (HDAC)6-mediated growth arrest in lung cancer cells. [Molecules] Abstract | Download Full Article

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Idiopathic Pulmonary Fibrosis: Recent Advances on Pharmacological Therapy
The authors provide an overview of the most recent clinical trials in idiopathic pulmonary fibrosis (IPF) and discuss how their results are going to change the clinical and clinical research landscape in IPF. [Pharmacol Ther] Abstract

Alveolar Development and Disease
Identification of surfactant proteins, cloning of the genes encoding them, and elucidation of their roles in the regulation of surfactant synthesis, structure, and function has provided increasing understanding of alveolar function and homeostasis in health and disease. This “perspective” seeks to consider developmental aspects of the pulmonary surfactant system and its importance in the pathogenesis of acute and chronic lung diseases related to alveolar homeostasis. [Am J Respir Cell Mol Biol] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

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Advanced Inhalation Therapies Granted European Orphan Drug Designation for Nitric Oxide for the Treatment of Cystic Fibrosis
Advanced Inhalation Therapies Ltd (AIT) announced that the European Commission, acting on the recommendation from the Committee for Orphan Medicinal Products of the European Medicines Agency, granted orphan medicinal product designation to AIT-CF, the company’s proprietary high dose formulation of nitric oxide, for the treatment of cystic fibrosis. [Advanced Inhalation Therapies Ltd] Press Release

FDA Approves BREO® ELLIPTA® for the Treatment of Adults with Asthma in the US
GlaxoSmithKline plc and Theravance, Inc. announced that the US Food and Drug Administration (FDA) has approved BREO® ELLIPTA® for the once-daily treatment of asthma in patients aged 18 years and older. [GlaxoSmithKline plc] Press Release

EMD Serono Initiates Co-Promotion of XALKORI® (Crizotinib) with Pfizer in the United States
EMD Serono announced it has begun co-promoting Pfizer’s anaplastic lymphoma kinase inhibitor XALKORI® (crizotinib) as part of its global strategic alliance with Pfizer. [EMD Serono] Press Release

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National Institutes of Health (United States)

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW International Meeting on Respiratory Pathogens 2015 (IMRP 2015)
September 2-4, 2015
Singapore, Singapore

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Senior PostDoc/Research Group Leader – Chronic Lung Disease (Ludwig Boltzmann Institute for Lung Vascular Research)

NEW Postdoctoral Position – Immunology and Virology (Herman B Wells Center for Pediatric Research)

NEW Postdoctoral Researcher – Systems Biology (Van Andel Research Institute)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Research Specialist – Lung and Vascular Biology (University of Illinois Chicago College of Medicine)

Postdoctoral Research Position – Lung Cancer (University of California, San Francicso)

Professorship – Lung Epithelial Cell Plasticity (Ludwig-Maximilians-Universitat München)

PhD Position – Development of a 3D In Vitro Model of Infected Airway (Helmholtz Centre for Infection Research)

Postdoctoral Researcher – Pulmonary Developmental Pathology (Drexel University College of Medicine)

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