Volume 4.10 | Mar 19

Pulmonary Cell News 4.10 March 19, 2015
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
Cell Therapy News on Facebook   PULCN on Twitter
Scientists Grow ‘Mini-Lungs’ to Aid the Study of Cystic Fibrosis
Scientists have successfully created ‘mini-lungs’ using stem cells derived from skin cells of patients with cystic fibrosis, and have shown that these can be used to test potential new drugs for this debilitating lung disease. [Press release from the University of Cambridge discussing online prepublication in Stem Cells and Development] Press Release | Abstract
Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
PUBLICATIONS (Ranked by impact factor of the journal)
In Vitro Epithelial Organoid Generation Induced by Substrate Nanotopography
Scientists examined the effect of substrate nanotopography on the morphogenesis of several types of epithelial cells and found that in response to the topography, Calu-3 and MDCK-II cells formed organoids that closely resemble their morphology in vivo. [Sci Rep] Full Article

Epithelial Cell Mitochondrial Dysfunction and PINK1 Are Induced by Transforming Growth Factor- Beta1 in Pulmonary Fibrosis
Investigators sought to determine the function of mitochondria and their clearance (mitophagy) in alveolar epithelial cell death and fibrosis. [PLoS One] Full Article

Hypoxia Down-Regulates Expression of Secretory Leukocyte Protease Inhibitor in Bronchial Epithelial Cells via TGF-β1
Scientists investigated the role of hypoxia on secretory leukocyte protease inhibitor (SLPI) production from the airway epithelium. Primary human bronchial epithelial cells were grown in sub-immersed cultures or as differentiated epithelium in air liquid interface cultures. Hypoxia decreased the constitutive production of SLPI by bronchial epithelial cells. [BMC Pulm Med] Abstract | Full Article

Influenza A Virus PB1-F2 Is Involved in Regulation of Cellular Redox State in Alveolar Epithelial Cells
Researchers investigated the possible involvement of the key virulence factor PB1-F2 in reactive oxygen species (ROS) generation and its contribution to the viral propagation and cell death. The key virulence factor PB1-F2 was found to be responsible, at least in part, for the ROS generation through lowering the superoxide anion dismutase 1 level in alveolar epithelial A549 cells. [Biochem Biophys Res Commun] Abstract

Enriched Inorganic Compounds in Diesel Exhaust Particles Induce Mitogen-Activated Protein Kinase Activation, Cytoskeleton Instability, and Cytotoxicity in Human Bronchial Epithelial Cells
Scientists assessed the effects of the diesel exhaust particles on ERK and JNK MAPKs activation, cell rheology (viscoelasticity), and cytotoxicity in bronchial epithelial airway cells. [Exp Toxicol Pathol] Abstract


Rho Guanine Nucleotide Exchange Factor 5 Increases Lung Cancer Cell Tumorigenesis via MMP-2 and CyclinD1 Upregulation
Researchers elucidated the role of Rho guanine nucleotide exchange factor 5 (ARHGEF5) in tumorigenesis of lung adenocarcinoma cells. ARHGEF5 knockdown by RNAi resulted in dramatically reduced proliferation, adhesion, invasion, and migratory capability of A549 and NCI-H1650 cells. [Mol Cancer Ther] Abstract

MicroRNA-223 Delivered by Platelet-Derived Microvesicles Promotes Lung Cancer Cell Invasion via Targeting Tumor Suppressor EPB41L3
Scientists explored the role of microRNA-223 (miR-223) derived from platelets in modulating lung cancer cell invasion. Incubation of human lung cancer A549 cells with platelet-secreted microvesicles resulted in rapid delivery of miR-223 into A549 cells, in which platelet miR-223 targeted EPB41L3 and thus promoted A549 cell invasion. [Mol Cancer] Abstract

Induction of p53-Independent Growth Inhibition in Lung Carcinoma Cell A549 by Gypenosides
Scientists investigated antiproliferative effect and mechanisms of bioactive compounds from Gynostemma pentaphyllum on lung carcinoma cell line A549. [J Cell Mol Med] Full Article

CCAAT/Enhancer Binding Protein β Is Dispensable for Development of Lung Adenocarcinoma
Researchers investigated whether C/EBPβ is required for normal lung development and whether its aberrant expression and/or activity contribute to lung tumorigenesis. They showed that C/EBPβ was expressed in both human normal pneumocytes and lung adenocarcinoma cell lines. [PLoS One] Full Article

View On-Demand Webinar: Optimized Differentiation of Bronchial Epithelial Cells
Calcium-Homeostasis and Ionic Mechanisms in Pulmonary Fibroblasts
The authors present the general concepts of [Ca2+]-homeostasis, of ionic mechanisms responsible for various Ca2+-fluxes and of regulation of gene expression by [Ca2+]. In each case, also summarize the original findings which pertain specifically to pulmonary fibroblasts. [Am J Respir Cell Mol Biol] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
Arch Biopartners Identifies Candidate Drug to Treat Psuedomonas Respiratory Infections
Arch Biopartners Inc. announced it has identified a new candidate drug to treat Pseudomonas aeruginosa respiratory infections. This new drug is the result of development work performed during 2014 and early 2015 by Dr. Daniel Hassett at the University of Cincinnati. [Arch Biopartners Inc. (Marketwire L.P.)] Press Release

Fred Hutch Unleashes Powerful Databases with Launch of Argos
The Fred Hutchinson Cancer Research Center, in conjunction with LabKey Software, has developed and launched Argos, an application that provides the interface and analytical power that researchers and clinicians will use to search for important patterns in cancer development, progression and treatment response. [Fred Hutchinson Cancer Research Center] Press Release

AstraZeneca Announces Positive Phase III Top-Line Results for PT003 from PINNACLE 1 and PINNACLE 2 Studies in COPD
AstraZeneca announced positive top-line results from the Phase III PINNACLE program, which included two pivotal 24-week studies to investigate the potential of PT003 to improve lung function in patients with chronic obstructive pulmonary disease (COPD). [AstraZeneca] Press Release

From our sponsor: Free human hematopoietic progenitors wallchart. Request your copy.
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW EMBO Workshop – Cellular and Molecular Mechanism of Tumor-Microenvironment Crosstalk
July 9-12, 2015
Tomsk, Russia

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Postdoctoral Position – Airway Disease and Inflammation (Brigham and Women’s Hospital Harvard Medical School)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Postdoctoral Scientist – Mechanisms of Pulmonary Fibrosis (Cedars-Sinai Medical Center)

PhD Studentship – Mouse Models of Asthma (University of Queensland)

Postdoctoral Scholar – Molecular Mechanisms of Lung Cancer, Lung Regeneration and Lung Development (University of California, San Francisco)

Postdoctoral Fellow – Fibrotic Lung Disease (University of California, San Diego)

Director – Vector Production (Sangamo BioSciences, Inc.)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Postdoctoral Fellow – Lung Cancer Development and Progression (The University of Texas MD Anderson Cancer Center)

Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Pulmonary Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here
Learn more about Pulmonary Cell News: Archives | Events | Contact Us