Volume 3.40 | Oct 16

Pulmonary Cell News 3.40 October 16, 2014
Pulmonary Cell News
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Researchers Identify ‘Achilles Heel’ in Metabolic Pathway that Could Lead to New Lung Cancer Treatments
Researchers have found an “Achilles heel” in a metabolic pathway crucial to stopping the growth of lung cancer cells. At the heart of this pathway lies peroxisome proliferation-activated receptor gamma (PPARγ), a protein that regulates glucose and lipid metabolism in normal cells. Researchers demonstrated that by activating PPARγ with antidiabetic drugs in lung cancer cells, they could stop these tumor cells from dividing. [Press release from the UT Southwestern Medical Center discussing publication in Cell Metabolism]
Press Release | Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
IL-27 and Type 2 Immunity in Asthmatic Patients: Association with Severity, CXCL9, and Signal Transducer and Activator of Transcription Signaling
Investigators evaluated IL-27 expression in human asthma alone and in combination with type 2 immunity to determine the relationship to disease severity and CXCL9 expression. They also modeled these interactions in vitro in human bronchial epithelial cells. [J Allergy Clin Immunol] Full Article

D Prostanoid Receptor 2 (Chemoattractant Receptor-Homologous Molecule Expressed on TH2 Cells) Protein Expression in Asthmatic Patients and Its Effects on Bronchial Epithelial Cells
Researchers investigated the bronchial submucosal D prostanoid receptor 2 expression in asthmatic patients and healthy control subjects and explored its functional role in epithelial cells. [J Allergy Clin Immunol]
Full Article

Src-Mediated EGF Receptor Activation Regulates Ozone-Induced Interleukin 8 Expression in Human Bronchial Epithelial Cells
Scientists examined the role of epidermal growth factor (EGF) receptor activation in ozone-induced expression of the chemokine interleukin 8 in human bronchial epithelial cells. [Environ Health Perspect]
Abstract | Full Article

High Basal Expression of Interferon-Stimulated Genes in Human Bronchial Epithelial (BEAS-2B) Cells Contributes to Influenza A Virus Resistance
Investigators compared replication kinetics of human H1N1 (A/USSR/77) influenza A viruses (IAVs) in normal primary human bronchial epithelial and two commonly used respiratory epithelial cell lines namely BEAS-2B and A549 cells. They found that IAV replication was distinctly poor in BEAS-2B cells in comparison with normal primary human bronchial epithelial, A549 and Madin-Darby canine kidney cells. [PLoS One] Full Article

Novel Peptide for Attenuation of Hyperoxia-Induced Disruption of Lung Endothelial Barrier and Pulmonary Edema via Modulating Peroxynitrite Formation
Researchers found that exposure of pulmonary artery endothelial cells to hyperoxia (95% oxygen and 5% CO2) for 48 hours resulted in disruption of monolayer barrier integrity in a manner of two phases, and apoptosis occurred in the second phase. [J Biol Chem] Abstract | Full Article

Identification of a Proximal Progenitor Population from Murine Fetal Lungs with Clonogenic and Multilineage Differentiation Potential
Using a Nkx2-1mCherry reporter mouse, researchers have identified and captured Nkx2-1-expressing lung progenitor cells from the proximal lung epithelium during fetal development. These cells formed clonal spheres in semisolid culture that could be maintained in vitro and demonstrated self-renewal and expansion capabilities over multiple passages. [Stem Cell Rep] Full Article


Specific Expression of OATPs in Primary Small Cell Lung Cancer (SCLC) Cells as Novel Biomarkers for Diagnosis and Therapy
The expression of organic anion transporting polypeptides (OATPs) was elucidated in cell lines from small cell lung cancer (SCLC) and lung carcinoids and in paraffin-embedded samples from primary and metastatic SCLCs. Scientists found a strong relationship between OATP expression and the origin of the cells, as cells from primary or metastatic SCLC and carcinoid tumors differ with respect to OATP levels. [Cancer Lett] Abstract

Waltonitone Induces Apoptosis through Mir-663-Induced Bcl-2 Downregulation in Non-Small Cell Lung Cancer
Investigators treated H460 and H3255 lung cancer cells using different concentration of waltonitone. They observed that waltonitone inhibited cell viability and induced apoptosis in a concentration dependent manner, with upregulation of caspase-3 cleavage. They also observed upregulation of miR-663, a potential tumor suppressor, after waltonitone treatment. [Tumor Biology] Abstract

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Pulmonary Vascular Changes in Asthma and COPD
The involvement of residential cells such as endothelial cells, smooth muscle cells and pulmonary fibroblasts, all appear to have a crucial role in the progression of vascular inflammation and remodelling. The regulatory abnormalities, growth factors and mediators implicated in the pulmonary vascular changes of asthma and chronic obstructive pulmonary disease (COPD) subjects and potential therapeutic targets are reviewed by the authors. [Pulm Pharmacol Ther] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
Aduro Expands Collaboration with Johnson & Johnson Innovation and Janssen for Lung Cancer Immunotherapies
Aduro BioTech, Inc., announced that it has entered into its second agreement with Janssen Biotech, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, granting an exclusive, worldwide license to certain product candidates engineered for the treatment of lung cancer and certain other cancers based on its novel LADD immunotherapy platform. [Aduro BioTech, Inc. (Business Wire)] Press Release

Catalent Applied Drug Delivery Institute to Collaborate with Lung Cancer Alliance to Conduct Patient Research
The Catalent Applied Drug Delivery Institute announced that it is to collaborate with the Lung Cancer Alliance on patient research in early October. The collaboration will focus on patient and caregiver insights, in order to better understand the unmet needs of patients when managing lung cancer, also the impact that treatment has on the patient overall, managing other disease states, and daily living. [Catalent, Inc] Press Release

ASCO Endorses CAP/IASLC/AMP Guideline on EGFR and ALK Molecular Testing for Patients with Lung Cancer
The American Society of Clinical Oncology (ASCO) issued an endorsement of the joint College of American Pathologists (CAP)/International Association for the Study of Lung Cancer/Association for Molecular Pathology clinical practice guideline on molecular testing for selection of patients with lung cancer for therapies targeting epidermal growth factor receptor and anaplastic lymphoma kinase.
[American Society of Clinical Oncology]
Press Release

FDA Approves Esbriet (Pirfenidone) for the Treatment of Idiopathic Pulmonary Fibrosis (IPF) in the United States
Roche announced that the U.S. Food and Drug Administration (FDA) has approved Esbriet (pirfenidone) as a treatment for idiopathic pulmonary fibrosis in the United States. [Hoffmann-La Roche Ltd.] Press Release

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European Medicines Agency (European Union)

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Therapeutic Goods Administration (Australia)
NEW 3rd Annual Cell Culture & Bioprocessing Congress 2014
November 20-21, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW PhD Positions – Cardiovascular-Pulmonary Science (Chonbuk National University)

Postdoctoral Researcher – Metabolomics of Pulmonary Medicine (Karolinska Institute)

Postdoctoral Fellow – Experimental Pulmonary Hypertension (Brigham and Women’s Hospital Harvard Medical School)

Investigator – Multiple Positions in Cellular & Molecular Medicine (Cleveland Clinic Lerner Research Institute)

Postdoctoral Fellow – Cardiopulmonary Molecular Biology (Hannover Medical School)

Postdoctoral Position – Pulmonary Research (University of Chicago)

Postdoctoral Researcher – Cancer (Ohio State University)

Postdoctoral Research Trainee – Acute Lung Injury (University of Tennessee Health Science Center)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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