Pulmonary Cell News

Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.

Deciphering Fibroblast-Induced Drug Resistance in Non-Small Cell Lung Carcinoma Through Patient-Derived Organoids in Agarose Microwells

[Lab On A Chip] Investigators introduced an agarose microwell platform designed for patient-derived organoid-based tumor and tumor microenvironment models, enabling rapid drug screening and resistance studies with small sample volumes.

Auranofin Repurposing for Lung and Pancreatic Cancer: Low CA12 Expression as a Marker of Sensitivity in Patient-Derived Organoids, with Potentiated Efficacy by AKT Inhibition

[Journal Of Experimental & Clinical Cancer Research] Our investigation employed a comprehensive drug screening of Auranofin in combination with eleven anticancer agents in cancerous PDAC and NSCLC patient-derived organoids, and non-cancerous pulmonary organoids.

Stimulatory Effect of Methylglyoxal on Capsaicin-Sensitive Lung Vagal Afferents in Rats: Role of TRPA1

[American Journal Of Physiology-Regulatory Integrative And Comparative Physiology] Scientists showed that intravenous injection of methylglyoxal in anesthetized, spontaneously breathing rats elicited pulmonary chemoreflexes characterized by apnea, bradycardia, and hypotension.

Bile Acid Metabolites Enhance Expression of Cathelicidin Antimicrobial Peptide in Airway Epithelium through Activation of the TGR5-ERK1/2 Pathway

[Scientific Reports] Researchers investigated the effects of bile acid metabolites produced from lithocholic acid by microbiota, on the regulation of innate immune responses connected to the expression of host defense peptide cathelicidin in lung epithelial cells.

Lung Repair and Regeneration: Advanced Models and Insights into Human Disease

[Cell Stem Cell] Scientists summarize recent research on the cellular complexity of the mammalian respiratory system with a focus on gas exchange and immunological defense functions of the lung.

UM Air Pollution Research Facility Receives $4.8 Million

[University of Manitoba] The new UM AirSAFE lab will be Canada’s first multi-disciplinary research centre for biomedical, engineering, natural science and occupational health experts to study how inhaled pollutants impact health and disease.

Streptococcus pneumoniae Extracellular Vesicles Aggravate Alveolar Epithelial Barrier Disruption via Autophagic Degradation of OCLN (Occludin)

[Autophagy] The authors observed that S. pneumoniae infections in mice led to severe lung injuries and alveolar epithelial barrier dysfunction.

YTHDF1-CLOCK Axis Contributes to Pathogenesis of Allergic Airway Inflammation through LLPS

[Cell Reports] Scientists reported that YTHDF1 was highly expressed in allergic airway epithelial cells and asthmatic patients and that it influenced proinflammatory responses.

Mast Cell Activation Disrupts Interactions Between Endothelial Cells and Pericytes During Early Life Allergic Asthma

[Journal Of Clinical Investigation] Using quantitative imaging in precision-cut lung slices, scientists reported that exposure of neonatal mice to house dust mite extract disrupted endothelial cell/pericyte interactions in adventitial areas.

Targeted Therapies Prime Oncogene-Driven Lung Cancers for Macrophage-Mediated Destruction

[Journal Of Clinical Investigation] Researchers developed a novel screening platform to identify drugs that rendered lung cancer cells more vulnerable to macrophage attack, and identified therapeutic synergy existed between genotype-directed therapies and anti-CD47 antibodies.

Ubiquitin Ligase Subunit FBXO9 Inhibits V-ATPase Assembly and Impedes Lung Cancer Metastasis

[Experimental Hematology & Oncology] Lentiviral vectors carrying miRNA-based shRNA sequences for gene-specific knockdown were generated, and Lenti-CRISPR-Cas9 vectors containing gene-specific sgRNA sequences were designed.

FAM83B Regulates Mitochondrial Metabolism and Anti-Apoptotic Activity in Pulmonary Adenocarcinoma

[Apoptosis] Multiple assays, such as CCK8, wound healing, EdU, and transwell assays, were employed to confirm the augmented chemotherapy resistance, heightened cell proliferation, migration, and invasion caused by FAM83B overexpression in lung adenocarcinoma cells.

Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

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