Volume 3.31 | Aug 14

Pulmonary Cell News 3.31 August 14, 2014
Pulmonary Cell News
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Wnt Ligand/Frizzled 2 Receptor Signaling Regulates Tube Shape and Branch-Point Formation in the Lung through Control of Epithelial Cell Shape
Researchers show that the Wnt receptor Frizzled 2 (Fzd2) is required for domain branch formation during the initial establishment of the respiratory tree. Live imaging and transcriptome analysis of lung-branching morphogenesis demonstrate that Fzd2 promotes changes in epithelial cell length and shape. [Proc Natl Acad Sci USA] Abstract
Model the Human Respiratory Epithelium with PneumaCult™-ALI. Click to View Data.
PUBLICATIONS (Ranked by impact factor of the journal)
Myb Permits Multilineage Airway Epithelial Cell Differentiation
Researchers identified transcription factor Myb as a key regulator that permits early multilineage differentiation of airway epithelial cells. Myb+ cells were identified as p63 and therefore distinct from basal progenitor cells, but were still negative for markers of differentiation. [Stem Cells] Abstract

Elimination of B-RAF in Oncogenic C-RAF-Expressing Alveolar Epithelial Type II Cells Reduces MAPK Signal Intensity and Lung Tumor Growth
Scientists describe a new mouse model for lung tumor development to investigate the role of B-RAF in oncogenic C-RAF-mediated adenoma initiation and growth. Conditional elimination of B-RAF in C-RAF BxB-expressing embryonic alveolar epithelial type II cells did not block adenoma formation. However, loss of B-RAF led to significantly reduced tumor growth. [J Biol Chem] Abstract | Full Article

TRIM72 Is Required for Effective Repair of Alveolar Epithelial Cell Wounding
Investigators characterized tripartite motif protein 72 (TRIM72) expression in lung tissues and investigated the role of TRIM72 in repair of alveolar epithelial cells. [Am J Physiol Lung Cell Mol Physiol] Abstract

Particle Pollution in Rio de Janeiro, Brazil: Increase and Decrease of Pro-Inflammatory Cytokines IL-6 and IL-8 in Human Lung Cells
Particle pollution from urban and industrialized regions in Rio de Janeiro, Brazil was analyzed for toxic and pro-inflammatory responses in human bronchial epithelial cells. [Environ Pollut] Abstract

Whole Genome Expression Analysis in Primary Bronchial Epithelial Cells after Exposure to Sulfur Mustard
To gain a better understanding of the mechanism of sulfur mustard (SM) toxicity, researchers investigated whole genome transcriptional changes after SM in primary human bronchial epithelial cells, as a model for inhalation exposure. [Toxicol Lett] Abstract

Brief Exposure to Cigarette Smoke Impairs Airway Epithelial Cell Innate Anti-Viral Defense
Researchers determined the impact of short-term exposure to cigarette smoke on innate immune responses of airway epithelial cells infected with human rhinovirus. [Toxicol In Vitro] Abstract


MicroRNA-26a/b Regulate DNA Replication Licensing, Tumorigenesis and Prognosis by Targeting CDC6 in Lung Cancer
Scientists demonstrate that microRNA (miR)-26a and miR-26b inhibit replication licensing and the proliferation, migration and invasion of lung cancer cells by targeting CDC6. [Mol Cancer Res] Abstract

MicroRNA-493 Suppresses Tumor Growth, Invasion and Metastasis of Lung Cancer by Regulating E2F1
Scientists investigated the role and mechanism of microRNA (miR)-493 in the development and progression of nonsmall-cell lung cancer. The ectopic expression of miR-493 impaired cell growth and invasion in vitro and in vivo. [PLoS One] Full Article

Differential Knockdown of TGF-β Ligands in a Three-Dimensional Co-Culture Tumor-Stromal Interaction Model of Lung Cancer
Scientists employed a model to examine how knockdown of transforming growth factor (TGF)-β ligands affects the behavior of different cell types. They developed lentivirus vectors carrying artificial microRNAs against human TGF-β1 and TGF-β2, and tested their effects in lung cancer cells and fibroblasts. [BMC Cancer] Full Article

Betulin Inhibits Lung Carcinoma Proliferation through Activation of AMPK Signaling
Betulin is an abundant, naturally occurring triterpene. Investigators reveal its antiproliferative effects and mechanisms using two lung carcinoma cells (A549 and NCI-292). [Tumor Biol] Abstract

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Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function
The authors highlight the multiple stem/progenitor populations in different regions of the adult lung, the plasticity of their behavior in injury models, and molecular pathways that support homeostasis and repair. [Cell Stem Cell] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
Skyepharma Acquires a Novel Inhaled Therapy Platform
Skyepharma PLC announced that it has acquired the global rights and related intellectual property (including granted patents and patent applications) to a novel inhaled therapy platform from Pulmagen Therapeutics (Synergy) Limited. Skyepharma will apply its expertise in inhaled drug development to develop a first product for chronic obstructive pulmonary disease through to the completion of a Phase II efficacy and safety trial sized to produce clinically significant data. [Skyepharma PLC] Press Release

FDA Approves Donor Lung Preservation Device that May Result in More Lung Transplants
The U.S. Food and Drug Administration (FDA) approved the XVIVO Perfusion System with STEEN Solution, a device for preserving donated lungs that do not initially meet the standard criteria for lung transplantation but may be transplantable if there is more time to observe and evaluate the organ’s function to determine whether the lung is viable for transplantation. [U.S. Food and Drug Administration] Press Release

From our sponsor: Pluripotent cell isolation for regenerative medicine. Request a free wallchart from Nature.
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 14th Annual Meeting of the International Society for Cell & Gene Therapy of Cancer (ISCGT)
September 25-27, 2014
Amsterdam, The Netherlands

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Research Assistant – Lung Cancer (University of Cambridge)

NEW Postdoctoral Research Fellow – Lung Diseases (University of Calgary)

NEW Postdoctoral Fellow – Development of the Esophagus and Lung (University of Rochester Medical Center)

Postdoctoral Fellowship – Lung Cancer (University College Dublin)

Postdoctoral Scientist – Transcriptional Networks in Lung Cancer (Cancer Research UK Manchester Institute)

Postdoctoral Fellow – Mechanisms of Lung Alveoli Epithelial Repair (University of Illinois Chicago College of Medicine)

Postdoctoral Research Associate – Lung Development Research (Women and Infants Hospital of Rhode Island)

Postdoctoral Research Trainee – Lung Injury and Epithelial Repair (University of Tennessee Health Science Center)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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