Volume 3.04 | Feb 6

Pulmonary Cell News 3.04 February 6, 2014
Pulmonary Cell News
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Alveolar Progenitor and Stem Cells in Lung Development, Renewal and Cancer
Researchers used molecular markers, lineage tracing and clonal analysis to map alveolar progenitors throughout the mouse lifespan. They showed that, during development, alveolar type (AT)1 and AT2 cells arise directly from a bipotent progenitor, whereas after birth new AT1 cells derive from rare, self-renewing, long-lived, mature AT2 cells that produce slowly expanding clonal foci of alveolar renewal. [Nature] Abstract
Model the Human Respiratory Epithelium with PneumaCult™-ALI. Click to View Data.
PUBLICATIONS (Ranked by impact factor of the journal)
Tracking Translocation of Industrially Relevant Engineered Nanomaterials (ENMs) across Alveolar Epithelial Monolayers In Vitro
To allow precise quantitation of translocation across lung epithelial cells, researchers developed a method for tracking industrially relevant metal oxide ENMs in vitro using neutron activation. [Nanotoxicology] Abstract

IL-33 Stimulates CXCL8/IL-8 Secretion in Goblet Cells but not Normally Differentiated Airway Cells
Scientists examined the effect of IL-33 on CXCL8/IL-8 secretion from goblet or normally differentiated human bronchial epithelial cells and signaling pathways associated with IL-33 activation in these cells. [Clin Exp Allergy] Abstract

The Role of Pneumococcal Histidine Triad (Pht) Proteins in the Attachment of Streptococcus pneumoniae to Respiratory Epithelial Cells
Scientists assessed the role of Pht proteins in pneumococcal binding to respiratory epithelial cells. Pneumococci were incubated with human nasopharyngeal epithelial cells and lung epithelial cells and the proportion of bound bacteria was measured by plating viable counts. [Infect Immun] Abstract

Microfluidic Shear Stress-Regulated Surfactant Secretion in Alveolar Epithelial Type II Cells In Vitro
Researchers investigated the role of flow-induced shear stress on the mechanisms regulating surfactant secretion in type II alveolar epithelial cells using microfluidic models. [Am J Physiol Lung Cell Mol Physiol] Abstract

Cadmium Induces Cytotoxicity in Human Bronchial Epithelial Cells through Upregulation of eIF5A1 and NF-KappaB
Researchers report that in CdCl2-exposed human bronchial epithelial cells, the level of p53 is dramatically decreased in a time- and dose-dependent manner, suggesting that the observed cadmium-induced cytotoxicity is not likely due to the pro-apoptotic function of p53. [Biochem Biophys Res Commun] Abstract

Protective Effect of Luteolin on Cigarette Smoke Extract-Induced Cellular Toxicity and Apoptosis in Normal Human Bronchial Epithelial Cells via the Nrf2 Pathway
Researchers evaluated the protective effects of luteolin on cigarette smoke extract-induced toxicity and apoptosis in normal human bronchial epithelial cells and explored its underlying mechanism(s). [Oncol Rep] Abstract


Antitumor Effect of miR-197 Targeting in p53 Wild-Type Lung Cancer
Scientists employed a locked nucleic acid-based anti-microRNA (miR) library in a functional screening to identify putative oncogenic miRNAs in non-small-cell lung cancer. By screening NIH-H460 and A549 cells, miR-197 was identified as a new functional oncomiR, whose downregulation induces p53-dependent lung cancer cell apoptosis and impairs the capacity to establish tumor xenografts in immunodeficient mice. [Cell Death Differ] Abstract

A Novel Cyclometallated Pt(II)-Ferrocene Complex Induces Nuclear FOXO3a Localization and Apoptosis and Synergizes with Cisplatin to Inhibit Lung Cancer Cell Proliferation
Researchers report the antiproliferative activity of a novel diastereomerically pure cycloplatinated complex 6a, against A549 non-small cell lung cancer. Mechanistic studies revealed that compound 6a induces nuclear translocation of a FOXO3a reporter protein as well as endogenous FOXO3a in U2OS and A549 cells, respectively. [Metallomics] Abstract

Aflatoxin G1-Induced Oxidative Stress Causes DNA Damage and Triggers Apoptosis through MAPK Signaling Pathway in A549 Cells
Researchers explored whether Aflatoxin G1 activates the reactive oxygen species/MAPK/apoptosis pathway to cause cell damage in human alveolar type II cells like the cell line A549. [Food Chem Toxicol] Abstract

Crizotinib Inhibits Migration and Expression of ID1 in MET-Positive Lung Cancer Cells: Implications for MET Targeting in Oncology
Crizotinib decreased p-MET, p-SRC and ID1 levels in ALK- and or MET-positive cell lines and inhibited cell migration. Knockdown of MET was comparable with the effect of crizotinib. [Future Oncol] Abstract

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Future Prospects for Tissue Engineered Lung Transplantation: Decellularization and Recellularization-Based Whole Lung Regeneration
The authors provide an overview of progress and recent knowledge about decellularization and recellularization-based approaches for generating tissue engineered lungs. [Organogenesis] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
KaloBios Reports Top-Line Data for Phase II Study of KB003 in Severe Asthma
KaloBios Pharmaceuticals, Inc. announced the completion of the randomized, double-blind placebo-controlled Phase II study of KB003, its anti-GM-CSF monoclonal antibody, in patients with severe asthma. [KaloBios Pharmaceuticals, Inc.] Press Release

Scripps Florida Scientist Awarded $1.8 Million to Develop New Approaches to Lung Cancer Therapy
Scientists from the Florida campus of The Scripps Research Institute have been awarded approximately $1.8 million from the National Cancer Institute of the National Institutes of Health to identify the signaling pathways that underlie lung cancer and to use this information to develop new therapeutic approaches. [The Scripps Research Institute] Press Release

LUNGevity Foundation Announces Additions to Scientific Advisory Board
LUNGevity Foundation announced two key additions to its Scientific Advisory Board: Dr. Julie Brahmer of Johns Hopkins and Dr. John Heymach of MD Anderson Cancer Center. [LUNGevity Foundation] Press Release

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Judges Side with FDA on Stem Cells
The D.C. Circuit Court of Appeals ruled that culturing a patient’s stem cells for therapeutic use falls under the aegis of the US Food and Drug Administration (FDA). FDA has said therapeutic stem cells should be regulated as drugs. [The Scientist] Editorial | Court Ruling

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 15th European Congress: Perspectives in Lung Cancer
March 14-15, 2014
Amsterdam, The Netherlands

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Postdoctoral Research Fellow – Lung Cancer Genetics (Fred Hutchinson Cancer Research Center)

Research Associate (Assistant Professor) – Pulmonary Medicine (University of Chicago)

PhD Studentships in Pulmonary Medicine (University of Giessen and Marburg Lung Center)

Chair in Lung Cancer Research (The University of Manchester)

Postdoctoral Scholar – Molecular Mechanisms of Lung Cancer, Lung Regeneration and Lung Development (UCSF)

Postdoctoral Position – Metabolomics of Pulmonary Medicine (Karolinska Institute)

Postdoctoral Fellow – Role of Stem Cells in Chronic Lung Disease (MedImmune)

Postdoctoral Research Fellow – Lung Development, Injury/Repair and Fibrosis (Mayo Clinic)

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