Volume 2.37 | Sep 19

Pulmonary Cell News 2.37 September 19, 2013
Pulmonary Cell News
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VEGF Controls Lung Th2 Inflammation via the miR-1-Mpl (Myeloproliferative Leukemia Virus Oncogene)-P-Selectin Axis
Researchers showed that lung-specific overexpression of vascular endothelial growth factor (VEGF) decreases microRNA (miR-1) expression in the lung, most prominently in the endothelium, and a similar down-regulation occurs in lung endothelium in Th2 inflammation models. [J Exp Med] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Reverse Genetics with a Full-Length Infectious cDNA of the Middle East Respiratory Syndrome Coronavirus
Scientists showed dipeptidyl peptidase 4 expression, Middle East respiratory syndrome coronavirus replication, and RNA and protein synthesis in human airway epithelial cell cultures, primary lung fibroblasts, primary lung microvascular endothelial cells, and primary alveolar type II pneumocytes, demonstrating a much broader tissue tropism than severe acute respiratory syndrome coronavirus. [Proc Natl Acad Sci USA] Abstract | Full Article

Protective Effect of Hypercapnic Acidosis in Ischemia-Reperfusion Lung Injury Is Attributable to Upregulation of Heme Oxygenase-1
Researchers investigated whether heme oxygenase-1 (HO-1) contributes to the protective effects of hypercapnic acidosis (HCA) in ischemia-reperfusion-induced lung injury. HO-1 siRNA significantly reversed HCA-mediated inhibition of NF-κB signaling in A549 cells subjected to hypoxia-reoxygenation. [PLoS One] Full Article

EGF-Induced Bronchial Epithelial Cells Drive Neutrophil Chemotactic and Anti-Apoptotic Activity in Asthma
Primary bronchial epithelial cells from healthy subjects, mild asthmatics and moderate-to-severe asthmatics were stimulated with epidermal growth factor (EGF), a model that mimics a repairing epithelium. EGF induced the epithelium to produce soluble mediators with neutrophil chemotactic and pro-survival activities which were related to the clinical severity of asthma. [PLoS One] Full Article

Cycloheximide and Lipopolysaccharide Downregulate αENaC mRNA via Different Mechanisms in Alveolar Epithelial Cells
The regulatory mechanisms of α epithelial Na+ channel (αENaC) mRNA expression by cycloheximide and lipopolysaccharide from Pseudomonas aeruginosa were studied. Both agents decreased αENaC mRNA expression to 50% of control values after 4 hours. [Am J Physiol Lung Cell Mol Physiol] Abstract


Co-Assessment of Cell Cycle and Micronucleus Frequencies Demonstrates the Influence of Serum on the In Vitro Genotoxic Response to Amorphous Monodisperse Silica Nanoparticles of Varying Sizes
Researchers investigated the influence of serum on the induction of micronuclei by nanoparticles of different sizes. Therefore they used A549 human lung carcinoma cells and amorphous monodisperse silica nanoparticles as models. [Nanotoxicology] Abstract

p190A RhoGAP Is Involved in EGFR Pathways and Promotes Proliferation, Invasion and Migration in Lung Adenocarcinoma Cells
Researchers documented inhibition of phosphorylation of p190-A RhoGAP (p190) by epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitors treatment in lung adenocarcinoma cell lines. Small interfering RNA-mediated knockdown of p190 leads lung adenocarcinoma cells to growth suppression and to inhibition of invasion/migration through inducing cell cycle arrest but not apoptosis. [Int J Oncol] Abstract

SIRT3 Regulates Cell Proliferation and Apoptosis Related to Energy Metabolism in Non-Small Cell Lung Cancer Cells through Deacetylation of NMNAT2
The interaction on growth, proliferation, apoptosis of non-small cell lung carcinoma (NSCLC) cell lines, and energy metabolism related to SIRT3 were investigated. Low expression of SIRT3 significantly inhibited mitotic entry, growth and proliferation of NSCLC cell lines and promoted apoptosis, which was related to energy metabolism involving in the interaction between SIRT3 and NMNAT2. [Int J Oncol] Abstract | Full Article

Targeting SHP2 for EGFR Inhibitor Resistant Non-Small Cell Lung Carcinoma
Researchers showed that Src homology 2-domain containing protein tyrosine phosphatase-2 (SHP2) is required for EGF-stimulated ERK1/2 phosphorylation and proliferation in epidermal growth factor receptor (EGFR) inhibitor resistant non-small cell lung cancer cell line H1975, which harbors the EGFR T790M/L858R double-mutant. [Biochem Biophys Res Commun] Abstract

The Antiproliferative Effect of Moringa oleifera Crude Aqueous Leaf Extract on Cancerous Human Alveolar Epithelial Cells
Scientists investigated the antiproliferative effect of Moringa oleifera leaf extract (MOE) in cancerous A549 lung cells. A significant increase in reactive oxygen species with a concomitant decrease in intracellular glutathione levels in MOE treated A549 cells was observed. [BMC Complement Altern Med]
Abstract | Full Article

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Pathology of Asthma
As the amount of information for patients with asthma increases, paradigm changes in immunology and molecular biology have resulted in an extensive evaluation of inflammatory cells and mediators involved in the pathophysiology of asthma. [Front Microbiol] Abstract

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Federal Grant Bolsters Pulmonary Fibrosis Research
Lisa Young, M.D., associate professor of Pediatrics and Medicine and Cell Biology, has been awarded a five-year, $1.9 million National Institutes of Health grant to study what causes cellular dysfunction and pulmonary fibrosis in patients with Hermansky-Pudlak syndrome. [Vanderbilt University Medical Center]
Press Release

Celtaxsys Announces Successful Completion of Phase I Clinical Trial for Development of CTX-4430
Atlanta-based pharmaceutical discovery and development company, Celtaxsys, Inc., announced the achievement of a significant clinical milestone for its lead clinical stage drug candidate, CTX-4430, for treatment of Cystic Fibrosis lung disease. [Celtaxsys, Inc.] Press Release

Ventana Receives Approval from China’s FDA for First Fully Automated IHC Companion Diagnostic Identifying ALK Protein Expression in Lung Cancer Patients
Ventana Medical Systems, Inc. announced the approval of the VENTANA ALK immunohistochemistry (IHC) assay by the Chinese Food and Drug Administration (CFDA) as a companion diagnostic to aid in the identification of patients for Pfizer’s CFDA-approved oncology product XALKORI®. [Ventana Medical Systems, Inc.] Press Release

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National Institutes of Health (United States)

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Best of Oncology 2013 East Conference
November 29, 3013
Toronto, Canada

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NEW Research Specialist – Lung Cancer (University of Illinois)

NEW Postdoctoral Fellow – Lung Research (Brigham & Women’s Hospital – Harvard Medical School)

Postdoctoral Research Position – Pathogenesis of Pulmonary Fibrosis (Biomedical Sciences Research Center)

Postdoctoral Research Candidate – Chronic Lung Diseases (European Respiratory Society / Marie Curie)

Postdoctoral Research Position – Molecular and Cellular Mechanism of Pulmonary Vascular Inflammation and Dysfunction (University of Oklahoma Health Sciences Center)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Postdoctoral Researcher – Respiratory Diseases Research (Boehringer Ingelheim Pharma GmbH & Co. KG)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Postdoctoral Associate – Lung Cancer (Yale Cancer Center)

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