Volume 9.25 | Jul 2

2020-07-02 | PULCN 9.25
Pulmonary Cell News by STEMCELL Technologies
Vol. 9.25 – 2 July, 2020
TOP STORY

COVID-19 Severity Correlates with Airway Epithelium–Immune Cell Interactions Identified by Single-Cell Analysis

In patients with COVID-19, epithelial cells showed an average three-fold increase in expression of the SARS-CoV-2 entry receptor ACE2, which correlated with interferon signals by immune cells.
[Nature Biotechnology]

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Airway Epithelial Integrin β4 Suppresses Allergic Inflammation by Decreasing CCL17 Production

Scientists determined the role of integrin β4 of airway epithelial cells in the regulation of Th2 response and identified the underpinning molecular mechanisms.
[Clinical Science]

Abstract

Distal Lung Epithelial Progenitor Cell Function Declines with Age

Investigators compared the lungs of 3- and 22-month old mice. They examined the gross morphological changes in these lungs, the density and function of epithelial progenitor populations and the epithelial gene expression profile.
[Scientific Reports]

Full Article

Indium Oxide Nanoparticles Induce Lung Intercellular Toxicity between Bronchial Epithelial Cells and Macrophages

The effects of indium oxide nanoparticles on lung cells associated with respiratory and immune barriers and the toxic effects of intercellular cascades were studied.
[Journal of Applied Toxicology]

Abstract

Paracrine SPARC Signaling Dysregulates Alveolar Epithelial Barrier Integrity and Function in Lung Fibrosis

As epithelial–mesenchymal interactions are essential for normal wound healing, through human 2D and 3D in vitro studies, researchers tested the hypothesis that idiopathic pulmonary fibrosis fibroblasts dysregulated alveolar epithelial homeostasis.
[Cell Death Discovery]

Full Article

UBE2T Promotes Radiation Resistance in Non-Small Cell Lung Cancer via Inducing Epithelial-Mesenchymal Transition and the Ubiquitination-Mediated FOXO1 Degradation

Using bioinformatic analyses, the authors found that UBE2T was associated with survival, tumor size, lymph node metastasis and distant metastasis. They used colony formation, EdU incorporation, scratch, transwell assays, flow cytometry, immunofluorescence and western blot to assess the role of UBE2T in vitro and in vivo.
[Cancer Letters]

Abstract

TGF-β Induced EMT and Stemness Characteristics are Associated with Epigenetic Regulation in Lung Cancer

Scientists determined whether EMT and stemness characteristics induced by TGF-β might be associated with epigenetic regulation in lung cancer.
[Scientific Reports]

Full Article

Berberine Chloride Suppresses Non-Small Cell Lung Cancer by Deregulating Sin3A/TOP2B Pathway In Vitro and In Vivo

The authors explored the effect of berberine chloride (BBC) on non-small cell lung cancer (NSCLC), and further expound the underlying mechanism of BBC induced NSCLC cell death in vitro and in vivo.
[Cancer Chemotherapy and Pharmacology]

Abstract

Cryptotanshinone Attenuates the Stemness of Non-Small Cell Lung Cancer Cells via Promoting TAZ Translocation from Nuclear to Cytoplasm

Cryptotanshinone attenuated the stemness of non-small cell lung cancer cancer stem cells, as evident by the reduced spheroid formation ability, stemness marker expression and ALDH1 activity.
[Chinese Medicine]

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REVIEWS

Advances in Immune Neoadjuvant/Adjuvant Therapy‐Related Adverse Events of Non‐Small Cell Lung Cancer

The authors discuss the role immunotherapy played in preoperative neoadjuvant and postoperative adjuvant treatment in lung cancer.
[Asia-Pacific Journal of Clinical Oncology]

Abstract

INDUSTRY AND POLICY NEWS

FibroGenesis Identifies Mechanism Responsible for Blocking COVID19-Like Lung Inflammation

FibroGenesis announced identification of molecular mechanisms associated with the potent reduction of lung inflammation previously reported by the company in an animal model of COVID-19 lung failure.
[FibroGenesis (PR Newswire Association LLC.)]

Press Release

Ipsen Joins Clinical Collaboration to Evaluate Cabozantinib plus Atezolizumab in Metastatic Non-Small Cell Lung Cancer and Metastatic Castration-Resistant Prostate Cancer

Ipsen announced it will join the Exelixis and Roche clinical collaboration and participate in the funding of the recently initiated CONTACT-01 and CONTACT-02 global Phase III pivotal trials.
[Ipsen Pharma]

Press Release

United Kingdom Plans ‘Office for Talent’ to Smooth Entry for Top Scientists

The UK government plans to set up an “office for talent” to oversee visas and make it easier to attract top scientists after Brexit, according to an R&D road map.
[ScienceInsider]

Editorial

Hong Kong Universities Rattled by New Security Law

Academics in Hong Kong are facing new worries after the mainland government abruptly imposed a controversial new security law that critics say could infringe on human rights and chill academic freedom.
[ScienceInsider]

Editorial

Amidst Uncertainty, Flexibility Is Key in Higher Ed, Faculty Say

Life sciences professors and other staff make contingency plans for more coronavirus-related disruptions in the coming school year.
[The Scientist]

Editorial

FEATURED EVENT

Micro-CT: Fancy Gadget or Indispensable Technology towards Accurate Quantification of Lung Disease and Therapy?

July 9
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JOB OPPORTUNITIES

Research Assistant Professor – Lung and Vascular Biology

Stanley Manne Children’s Research Institute Ann & Robert H. Lurie Children’s Hospital of Chicago – Chicago, Illinois, United States

Postdoctoral Fellow – Lung Cancer Biology

Virginia Commonwealth University – Richmond, Virginia, United States

Postdoctoral Positions – Single Molecule Biology

NYU School of Medicine – New York, New York, United States

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Helmholtz Zentrum München – Neuherberg, Germany

Postdoctoral Research Fellow – Viral and Bacterial Lung Infections

Johns Hopkins University School of Medicine – Baltimore, Maryland, United States

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