Volume 9.23 | Jun 18

2020-06-18 | PULCN 9.23
Pulmonary Cell News by STEMCELL Technologies
Vol. 9.23 – 18 June, 2020

Antisense Oligonucleotide-Mediated Correction of CFTR Splicing Improves Chloride Secretion in Cystic Fibrosis Patient-Derived Bronchial Epithelial Cells

Researchers tested an antisense oligonucleotide targeting the cystic fibrosis (CF) transmembrane conductance regulator c.3718-2477C>T mutation and showed that it effectively blocks aberrant splicing in primary bronchial epithelial cells from CF patients with the mutation.
[Nucleic Acids Research]

Full Article

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miR-410 Induces Both Epithelial-Mesenchymal Transition and Radioresistance through Activation of the PI3K/mTOR Pathway in Non-Small Cell Lung Cancer

Scientists demonstrated that PTEN was a direct target of miR-410 by using bioinformatic tools and dual-luciferase reporter assays, and the miR-410-induced epithelial–mesenchymal transition and radioresistance were reversed by PI3K, Akt, and mTOR inhibitors or by restoring the expression of PTEN in non-small cell lung cancer cells.
[Signal Transduction and Targeted Therapy]

Full Article

Annexin-A1 Promotes RIG-I-Dependent Signaling and Apoptosis via Regulation of the IRF3–IFNAR–STAT1–IFIT1 Pathway in A549 Lung Epithelial Cells

Researchers explored the role of Annexin A1 (ANXA1) in Influenza Type A viruses infection of A549 lung epithelial cells further in the context of RIG-I-dependent signaling using A549 and Crispr/Cas9 ANXA1 deleted cells.
[Cell Death & Disease]

Full Article

SIRT7‐Mediated Modulation of Glutaminase 1 Regulates TGF‐β‐Induced Pulmonary Fibrosis

Investigators showed that the profibrotic actions of TGF‐β were mediated, at least in part, through a metabolic maladaptation in glutamine metabolism and how the inhibition of glutaminase 1 reversed pulmonary fibrosis.
[FASEB Journal]

Full Article

Wnt/β‐Catenin Signaling Is Critical for Regenerative Potential of Distal Lung Epithelial Progenitor Cells in Homeostasis and Emphysema

Scientists identified an organoid‐forming adult distal lung epithelial progenitor cell population characterized by a low Wnt/β‐catenin activity, which was enriched in club and alveolar epithelial type II cells.
[Stem Cells]

Full Article

Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells

Phosphoproteomic analyses identified many protein kinase A (PKA) substrates and mechanisms of action. In particular, PKA activity was required for the propagation of small cell lung cancer stem cells in transplantation studies.
[Cancer Cell]

AbstractGraphical Abstract

High-Capacity Poly(2-oxazoline) Formulation of TLR 7/8 Agonist Extends Survival in a Chemo-Insensitive, Metastatic Model of Lung Adenocarcinoma

Investigators showed that our unique poly(2-oxazoline)–based nanomicellar formulation of Resiquimod, an imidazoquinoline Toll-like receptor 7/8 agonist, had a superior tumor inhibitory effect in a metastatic model of lung adenocarcinoma, relative to anti–PD-1 therapy or platinum-based chemotherapy.
[Science Advances]

Full Article

Targeting Lung Cancer Stem Cells Using Combination of Tel and Docetaxel Liposomes in 3D Cultures and Tumor Xenografts

Scientists demonstrated for the first time the efficacy of Docetaxel liposomes in combination with telmisartan in 3D cultures of H460 cells by using polysaccharide-based hydrogels and also in xenograft model of Docetaxel resistant H460 derived CD133+ lung tumors.
[Toxicology and Applied Pharmacology]

AbstractGraphical Abstract

MDL-800, An Allosteric Activator of SIRT6, Suppresses Proliferation and Enhances EGFR-TKIs Therapy in Non-Small Cell Lung Cancer

Scientists investigated whether MDL-800, an allosteric activator of sirtuin 6, exerted antiproliferation effect against non-small cell lung carcinoma cells in vitro and in vivo.
[Acta Pharmacologica Sinica]



Targeting Focal Adhesion Kinase in Cancer Cells and the Tumor Microenvironment

Scientists discuss the role of nuclear FAK as a driver for tumor cell survival as well as potential therapeutic strategies to target FAK in both tumors and the tumor microenvironment.
[Experimental and Molecular Medicine]

Full Article


Nuvaira Announces FDA Breakthrough Designation for AIRFLOW-3 Pivotal Trial Device

Nuvaira announced that its Nuvaira® Lung Denervation System has been designated as a Breakthrough Device by the FDA.

Press Release

Creatv Announces Ability to Predict Immunotherapy Treatment Response for Non-Small Cell Lung Cancer Using a Simple Blood Test

Creatv Microtech has pioneered a blood test to predict treatment response in patients with stage II-III NSCLC treated with chemoradiation therapy and consolidated immunotherapy.
[Business Wire, Inc.]

Press Release


American Association for Cancer Research (AACR) Annual Meeting 2020 – Virtual Meeting II

2020-06-22 – 2020-06-24

> See All Events


Postdoctoral Fellow – Lung Cancer Biology

Virginia Commonwealth University – Richmond, Virginia, United States

Postdoctoral Positions – Single Molecule Biology

NYU School of Medicine – New York, New York, United States

Science Manager – Lung Diseases

Helmholtz Zentrum München – Neuherberg, Germany

Research Group Leader – Cardiopulmonary Institute

Max Planck Institute for Heart and Lung Research – Bad Nauheim, Germany

Postdoctoral Research Fellow – Viral and Bacterial Lung Infections

Johns Hopkins University School of Medicine – Baltimore, Maryland, United States

Postdoctoral Associate – Lung Cancer Research

Yale University – New Haven, Connecticut, United States

Associate Professor – Cell Biology

Dana-Farber Cancer Institute – Boston, Massachusetts, United States

Principal Scientist – Respiratory Inflammation Research

Amgen Inc. – South San Francisco, California, United States

Branch Chief – Integrative Tumor Epidemiology

NIH National Cancer Institute – Bethesda, Maryland, United States

Research Associate – Cystic Fibrosis

Michigan State University – East Lansing, Michigan, United States

> See All Jobs

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