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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Loss of ZNF451 Mediates Fibroblast Activation and Promotes Lung Fibrosis
[Respiratory Research] GEO dataset analysis, RT‒PCR, and immunoblot assays were used to examine the expression of zinc finger protein 451 (ZNF451) in pulmonary fibrosis.
HERC5 Downregulation in Non-Small Cell Lung Cancer Is Associated with Altered Energy Metabolism and Metastasis
[Journal of Experimental & Clinical Cancer Research] Investigators assessed cell proliferation, colony formation potential, anchorage-independent growth, migration, and wound healing in NSCLC cell line models with HERC5 overexpression or knockout.
Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
[Cancer Discovery] Using comprehensive genomic profiling among >600,000 patients, scientists identified activating MET tyrosine kinase domain point mutations as putative oncogenic driver across diverse cancers, with a frequency of ~0.5%.
Cell-Free DNA Methylation in the Clinical Management of Lung Cancer
[Trends in Molecular Medicine] Investigators discuss the current state of the art in cell-free (cf)DNA methylation analysis, examine the unique features and limitations of these new methods in a clinical context, propose two models for applying cfDNA methylation data for lung cancer screening, and discuss future research directions.
American Lung Association and LUNGevity Foundation Announce $3 Million Research Partnership to Intercept Lung Cancer
[American Lung Association] In a collaborative effort to end lung cancer, the American Lung Association and LUNGevity Foundation have joined forces to invest $3 million over the next three years in research aimed at intercepting lung cancer.
Oncogene-Driven Non-Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations
[Cancer Research] To better understand the clonal architecture and genomic landscape of non-smoking-related oncogene-driven tumors in smokers compared to typical-smoking NSCLCs, scientists investigated genomic and transcriptomic alterations in 173 tumor sectors from 48 NSCLC patients.
USP7 Upregulated by TGF-β1 Promotes Ferroptosis via Inhibiting LATS1-YAP Axis in Sepsis-Induced Acute Lung Injury
[iScience] Researchers investigated the interactive roles of TGF-β1, USP7, and YAP in ferroptosis during sepsis-secondary acute lung injury.
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer
[Cancer Discovery] In immune-hot adenocarcinomas, spatial niches of T cells and macrophages increased with clonal neoantigen burden, whereas such an increase was observed for niches of plasma and B cells in immune-excluded squamous cell carcinomas
DRD1 Suppresses Cell Proliferation and Reduces EGFR Activation and PD-L1 Expression in NSCLC
[Molecular Oncology] Expression and methylation of dopamine receptor D1 (DRD1) were measured using RNAseq and RT-PCR in NSCLC samples, and validated using publicly available datasets.
Vangl-Dependent Mesenchymal Thinning Shapes the Distal Lung during Murine Sacculation
[Developmental Cell] Investigators showed that planar cell polarity (PCP) was dispensable in the airway epithelium for sacculation. They found a Celsr1-independent role for the PCP component Vangl in the pulmonary mesenchyme.
The Role of Vasculature and Angiogenesis in Respiratory Diseases
[Angiogenesis] The authors outline the importance of vascular remodeling and angiogenesis in a variety of non-neoplastic and neoplastic acute and chronic respiratory diseases such as lung infection, chronic obstructive pulmonary disease, lung fibrosis, pulmonary hypertension, and lung cancer.
Tracing the Origin of Alveolar Stem Cells in Lung Repair and Regeneration
[Cell] Researchers introduced a dual recombinase-mediated intersectional genetic lineage tracing approach, enabling precise investigation of alveolar type 2 cellular origins during lung homeostasis, injury, and repair.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
