Volume 5.20 | May 26 - Pulmonary Cell News

Pulmonary Cell News 5.20 May 26, 2016

TOP STORY

Increased Mitochondrial Arginine Metabolism Supports Bioenergetics in Asthma
Arginase 2 overexpression in a human bronchial epithelial cell line accelerated oxidative bioenergetic pathways and suppressed hypoxia-inducible factors and phosphorylation of the signal transducer for atopic Th2 inflammation STAT6, both of which are implicated in asthma etiology. [J Clin Invest]
Full Article | Press Release

Model the Human Respiratory Epithelium with PneumaCult™-ALI. Click to View Data.

PUBLICATIONS (Ranked by impact factor of the journal)

Epigenetic Silencing of miR-218 by the lncRNA CCAT1, Acting via BMI1, Promotes an Altered Cell Cycle Transition in the Malignant Transformation of HBE Cells Induced by Cigarette Smoke Extract
Cigarette smoke extract caused an altered cell cycle and increased CCAT1 levels and decreased miR-218 levels in human bronchial epithelial (HBE) cells. [Toxicol Appl Pharmacol] Abstract

Developing a Gene Biomarker at the Tipping Point of Adaptive and Adverse Responses in Human Bronchial Epithelial Cells
Investigators examined cellular responses of the tracheobronchial airway to zinc (Zn) exposure, a model oxidant. Airway derived BEAS-2B cells exposed to 2–10 μM Zn²⁺ elicited concentration- and time-dependent cytotoxicity. [PLoS One] Full Article

Epithelial-Mesenchymal Transition and FOXA Genes during Tobacco Smoke Carcinogen Induced Transformation of Human Bronchial Epithelial Cells
An in vitro transformation model of human bronchial epithelial cells was used to study long-term effects of tobacco smoke carcinogens on epithelial-mesenchymal transition and the forkhead box transcription factors FOXA1 and FOXA2. [Toxicol In Vitro] Abstract

Placenta Growth Factor Contributes to Cell Apoptosis and Epithelial-to-Mesenchymal Transition in the Hyperoxia-Induced Acute Lung Injury
Exogenous placenta growth factor (PLGF) inhibited viability of alveolar epithelial cells type II (AECIIs). In addition, treatment of PLGF increased the percentage of apoptotic cells, regulated the expression of E-cadherin and α-smooth muscle actin in the primary AECIIs. [Life Sci] Abstract

LUNG CANCER

miR-29b Mediates NF-ĸB Signaling in KRAS-Induced Non-Small Cell Lung Cancers
To identify miRNAs implicated in EGFR signaling, investigators transduced bronchial epithelial BEAS-2B cells with retroviral vectors expressing KRASG12V and monitored miRNA expression patterns by microarray analysis. [Cancer Res] Abstract

The DEAD-Box RNA Helicase 51 Controls Non-Small Cell Lung Cancer Proliferation by Regulating Cell Cycle Progression via Multiple Pathways
Scientists assessed the role of DDX51 in non-small cell lung cancer using a siRNA-based approach. DDX51 siRNA-expressing cells exhibited a slower cell proliferation rate and underwent arrest in S-phase of the cell cycle compared with control cells. [Sci Rep] Full Article

Latcripin-13 Domain Induces Apoptosis and Cell Cycle Arrest at the G1 Phase in Human Lung Carcinoma A549 Cells
The authors report that Latcripin-13 domain induced cell cycle arrest in the G1 phase and caused the apoptosis of human lung carcinoma A549 cells via the GSK3β-cyclin D1 and caspase-8/NF-κB signaling pathways. [Oncol Rep] Abstract

Inhibition of Ceramide Glucosylation Sensitizes Lung Cancer Cells to ABC294640, a First-in-Class Small Molecule SphK2 Inhibitor
Researchers showed that ABC294640 suppressed growth of primary and A549 human lung cancer cells, but spared sphingosine kinase 2 (SphK2)-low lung epithelial cells. [Biochem Biophys Res Commun] Abstract

Learn More: Standardized Tools for Cancer Research

REVIEWS

Emerging Treatment for ALK-Positive Lung Cancer
The authors discuss emerging treatment options in ALK-positive advanced non-small cell lung cancer and strategies to overcome resistance mechanisms, including newer generation of ALK inhibitors, Hsp90 inhibitors and immunotherapy. [Expert Opin Emerg Drugs] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

INDUSTRY NEWS

Flatiron Health and the FDA Embark on Cancer Research Collaboration
Flatiron Health and the U.S. Food and Drug Administration (FDA) have signed a research collaboration agreement to determine how real-world evidence derived from de-identified, HIPAA-compliant patient data captured outside of clinical trials can provide new insights into the safety and effectiveness of emerging anti-cancer therapies such as immunotherapeutic agents. [Flatiron Health, Inc.] Press Release

Therabron Therapeutics Completes Enrollment of Phase II Clinical Trial for Lead Product Candidate CG100 for the Prevention of Chronic Lung Disease in Preterm Infants
Therabron Therapeutics, Inc. announced the company has completed enrollment of its Phase II clinical trial evaluating its lead product candidate, CG100, for the prevention of chronic respiratory morbidity in premature infants. [Therabron Therapeutics, Inc.] Press Release

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POLICY NEWS

Overtime Pay for Postdoctoral Scientists Is Welcome — But Could Mean Fewer Positions
In a long-overdue revision of American overtime regulations, the Department of Labor explicitly included postdocs among those who are eligible for overtime pay if they earn less than $47,476 per year. [Nature News] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW ICCSCE 2016: 18^th International Conference on Cell and Stem Cell Engineering
September 15-16, 2016
Rome, Italy

Visit our events page to see a complete list of events in the pulmonary cell community.

JOB OPPORTUNITIES

NEW Postdoctoral Fellow – Lung Cancer (German Cancer Research Center)

NEW Postdoctoral Position – Lung Alveolar Epithelial Cell Biology/Differentiation (University of Southern California)

Scientific Communications and Publishing Coordinator (STEMCELL Technologies Inc.)

Postdoctoral Researcher – Biochemistry/Molecular Biology (National Jewish Health)

Postdoctoral Fellow – Immunology (New York University Medical Center)

Postdoctoral Fellow – Lung Disease (Oklahoma State University)

Postdoctoral Fellow – Cell Biology (University of Chicago)

Faculty Positions – Basic or Translational Research (Cleveland Clinic)

Postdoctoral Research Fellow – Pancreatic and Lung Cancer (University of California – San Francisco)

Postdoctoral Fellows – Cancer Research (National University of Singapore)

Postdoctoral Position or Research Scientist – Mucosal Immunology (Qu Biologics)

Director Clinical Research – Medical Oncology (Fred Hutchinson Cancer Research Center)

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