Volume 5.18 | May 12

Pulmonary Cell News 5.18 May 12, 2016
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS Mutant Lung Cancer
Scientists report that epithelial-to-mesenchymal transition rewires the expression of receptor tyrosine kinases, leading to differential feedback activation of the mitogen-activated protein kinase pathway following MEK inhibition. In epithelial-like KRAS mutant lung cancers, this feedback was attributed to ERBB3-mediated activation of MEK and AKT. [Cancer Discov] Abstract
Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
 
PUBLICATIONS (Ranked by impact factor of the journal)
Pseudomonas Toxin Pyocyanin Triggers Autophagy: Implications for Pathoadaptive Mutations
Investigators demonstrated that pyocyanin, a well-described P. aeruginosa virulence factor that plays an important role in the initial infection, promotes autophagy in bronchial epithelial cells. Disruption of phzM, which is required for pyocyanin biosynthesis, leads to a significant reduction in autophagy in Beas-2B cells and lung tissues. [Autophagy] Abstract

Pulmonary Administration of 1.25-Dihydroxyvitamin D3 to the Lungs Induces Alveolar Regeneration in a Mouse Model of Chronic Obstructive Pulmonary Disease
Researchers investigated the differentiation-inducing effect on undifferentiated lung cells and the alveolar regenerative effect of the active vitamin 1.25-dihydroxy vitamin D3 with the ultimate goal of developing a novel curative drug for chronic obstructive pulmonary disease. [J Control Release] Abstract

Role of Hif2α Oxygen Sensing Pathway in Bronchial Epithelial Club Cell Proliferation
Researchers found that in vivo exposure to hypoxia led to a profound increase in bronchial epithelial cell proliferation mainly confined to Club cells. Interestingly, this response was executed by hypoxia-inducible factor 2α (HIF2α), which controls the expression of FoxM1, a recognized proliferative factor of Club cells. [Sci Rep] Full Article

Formaldehyde Induces Rho-Associated Kinase Activity to Evoke Airway Hyperresponsiveness
Air-liquid interface-differentiated human bronchial epithelial cells were exposed to formaldehyde or vehicle and co-cultured with human airway smooth muscle (HASM) cells. Agonist-induced intracellular Ca2+ and myosin light chain phosphatase phosphorylation were determined in the co-cultured HASM cells. [Am J Respir Cell Mol Biol] Abstract

Placental Growth Factor (PLGF) Triggers EMT-Like Changes in Rat Type II Alveolar Epithelial Cells: Activation of NFκB Signaling Pathway
Primary type II alveolar epithelial cells (AECs) were isolated for neonatal Sprague-Dawley rats and treated with different doses of recombinant PLGF for 48 hours. As compared to the untreated AECs, exogenous PLGF induced a reduction of E-cadherin and increases of vimentin and fibronectin in a dose-dependent manner. [Basic Clin Pharmacol Toxicol] Abstract

LUNG CANCER

GPC5, a Novel Epigenetically Silenced Tumor Suppressor, Inhibits Tumor Growth by Suppressing Wnt/β-Catenin Signaling in Lung Adenocarcinoma
Researchers found that glypican-5 (GPC5) was significantly hypermethylated in lung cancer tissues and lung cancer cell lines compared with normal lung tissues. The methylation level of GPC5 was negatively correlated with its transcriptional expression. [Oncogene] Abstract

Cetuximab-Modified Mesoporous Silica Nano-Medicine Specifically Targets EGFR-Mutant Lung Cancer and Overcomes Drug Resistance
Scientists designed a cetuximab-capped mesoporous silica nanoparticle as the drug carrier to specifically target epidermal growth factor receptor-mutant lung cancer cells and efficiently release loaded drugs including doxorubicin and gefitinib. [Sci Rep] Full Article

Morphine Suppresses Lung Cancer Cell Proliferation through the Interaction with Opioid Growth Factor Receptor: An In Vitro and Human Lung Tissue Study
The human lung cancer cell line, H1975, which overexpressed opioid growth factor receptor (OGFR) but not [mu]-opioid receptors, was selected for further analysis to verify the interaction between morphine and OGFR and the impact of morphine on cancer cell growth. [Anesth Analg] Abstract

Exosomes-Derived MiR-302b Suppresses Lung Cancer Cell Proliferation and Migration via TGFβRII Inhibition
Researchers examined the effect of exosomes-derived miR-302b on lung cancer cells proliferation and explain the potential mechanism. The effect of exosomes derived from 95C cells and 95D cells with different metastatic ability on lung cancer cell proliferation and migration were analyzed by MTT assay and Transwell assays, respectively. [Cell Physiol Biochem] Full Article

ANGPTL4 Correlates with NSCLC Progression and Regulates Epithelial-Mesenchymal Transition via ERK Pathway
The authors evaluated the clinical significance and biological role of ANGPTL4 in non-small cell lung cancer (NSCLC), the most common lung cancer subtype. Quantitative reverse transcription-polymerase chain reaction was used for examining the mRNA level of ANGPTL4 in NSCLC tissues and adjacent non-tumor tissues, NSCLC cell lines, and the immortalized human bronchial epithelial cell line HBE, respectively. [Lung] Abstract

Watch Now: Webinar on Gastrointestinal Organoids by Dr. Meritxell Huch
 
REVIEWS
Diesel Exhaust: Current Knowledge of Adverse Effects and Underlying Cellular Mechanisms
The authors describe the fundamental properties of diesel exhaust as well as the human respiratory tract and conclude that adverse health effects of diesel exhaust not only emerge from its chemical composition, but also from the interplay between its physical properties, the physiological and cellular properties, and function of the human respiratory tract. [Arch Toxicol] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
INDUSTRY NEWS
Bayer Terminates Phase II Study with Riociguat in Patients with Pulmonary Hypertension Associated with Idiopathic Interstitial Pneumonias
Following the recommendation of an independent Data Monitoring Committee, Bayer is terminating its Phase II study investigating riociguat in patients with pulmonary hypertension associated with idiopathic interstitial pneumonias with immediate effect. [Bayer AG] Press Release

Agenus Commences Phase I Clinical Trial of its CTLA-4 Checkpoint Antibody to Treat Solid Tumors
Agenus Inc. announced that the first patient has been dosed in the company’s Phase I clinical trial of AGEN1884, an anti-CTLA-4 checkpoint antibody. [Agenus Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 6th Australian Lung Cancer Conference
August 18-20, 2016
Melbourne, Australia

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Immunology (New York University Medical Center)

Postdoctoral Position – Cancer Research (German Cancer Research Center)

Postdoctoral Fellow – Lung Disease (Oklahoma State University)

Senior Research Associate – Cell Biology (University College London)

Postdoctoral Fellow – Cell Biology (University of Chicago)

Faculty Positions – Basic or Translational Research (Cleveland Clinic)

Postdoctoral Research Fellow – Pancreatic and Lung Cancer (University of California – San Francisco)

Postdoctoral Fellows – Cancer Research (National University of Singapore)

Postdoctoral Fellowship – Genomics (Brigham & Women’s Hospital – Harvard Medical School)

Postdoctoral Position or Research Scientist – Mucosal Immunology (Qu Biologics)

Director Clinical Research – Medical Oncology (Fred Hutchinson Cancer Research Center)


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