Volume 5.11 | Mar 24

Pulmonary Cell News 5.11 March 24, 2016
Pulmonary Cell News
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Inhibition of Endotoxin-Induced Airway Epithelial Cell Injury by a Novel Family of Pyrrol Derivates
Scientists evaluated the ability of a new family of 1,2,3,5-tetrasubstituted pyrrol compounds for attenuating lipopolysaccharide (LPS)-induced inflammation and apoptosis in an in vitro LPS-induced airway epithelial cell injury model based on the first steps of the development of sepsis-induced acute respiratory distress syndrome. [Lab Invest] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
A Novel Approach for Ovine Primary Alveolar Epithelial Type II Cell Isolation and Culture from Fresh and Cryopreserved Tissue Obtained from Premature and Juvenile Animals
Researchers developed and optimized ovine lung tissue cryopreservation and primary alveolar epithelial type II cell culture methodologies for the purposes of dissecting mechanisms at the cellular level to elucidate responses observed in vivo. [PLoS One] Full Article

Carbocisteine Attenuates TNF-α-Induced Inflammation in Human Alveolar Epithelial Cells In Vitro through Suppressing NF-κB and ERK1/2 MAPK Signaling Pathways
Researchers investigated the mechanisms underlying the anti-inflammatory effects of carbocisteine in human alveolar epithelial cells in vitro. [Acta Pharmacol Sin] Abstract

Conjugated Linoleic Acids Suppress Inflammatory Response and ICAM-1 Expression through Inhibition of NF-κB and MAPK Signaling in Human Bronchial Epithelial Cells
Investigators evaluated the suppressive effects of cis-9, trans-11-conjugated linoleic acids on the expression of proinflammatory cytokines and intercellular adhesion molecule 1 in TNF-α-stimulated human bronchial epithelial cells. [Food Funct] Abstract


Functional Role of Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1) in NSCLC
The authors report that the levels of EIF4G1 expression are much higher in non–small cell lung cancer (NSCLC) cell lines and tumor tissues than those in the normal lung cells and adjacent normal tissues from the same patients. Using shRNA to knock down EIF4G1 expression stably, they found EIF4G1 was required for NSCLC cell proliferation, anchorage-independent growth, migration and invasion. [Oncotarget] Full Article

Combination of Gefitinib and Pemetrexed Prevents the Acquisition of TKI-Resistance in NSCLC Cell Lines Carrying EGFR Activating Mutation
Researchers investigated the potential of combining gefitinib and pemetrexed in preventing the acquisition of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-resistance in non-small cell lung cancer (NSCLC) cell lines harboring EGFR exon 19 deletion. [J Thorac Oncol] Abstract

TRAIL-Coated Lipid-Nanoparticles Overcome Resistance to Soluble Recombinant TRAIL in Non-Small Cell Lung Cancer Cells
Apo2L/TRAIL-induced cytotoxicity was assessed on different non-small cell lung cancer (NSCLC) cell lines with different sensitivity to soluble TRAIL and on primary human tumor cells from three patients suffering from NSCLC cancer. [Nanotechnology] Abstract

Physalin A Induces G2/M Phase Cell Cycle Arrest in Human Non-Small Cell Lung Cancer Cells: Involvement of the p38 MAPK/ROS Pathway
Scientists investigated the effects of physalin A on proliferation and cell cycle distribution of the human non-small cell lung cancer A549 cell line, and the potential mechanisms involved. [Mol Cell Biochem] Abstract

A Novel Small Molecule, Rosline, Inhibits Growth and Induces Caspase-Dependent Apoptosis in Human Lung Cancer Cells A549 through a Reactive Oxygen Species-Dependent Mechanism
Using non-small cell lung cancer cell A549 to screen against a structurally novel and diverse synthetic small molecule library of 2,400 compounds, researchers identified a molecule named rosline that has strong anti-proliferation activity on A549 cells with a 50% cell growth inhibitory concentration of 2.87±0.39µM. [Cell Biol Int] Abstract

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Murine Models of Cardiovascular Comorbidity in Chronic Obstructive Pulmonary Disease
The authors summarize the currently used murine models of chronic obstructive pulmonary disease (COPD) and atherosclerosis, separate and combined, and discuss the relevance of these models for studying the pathogenesis and development of new treatments for COPD patients with atherosclerosis. [Am J Physiol Lung Cell Mol Physiol] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
Argos Therapeutics Announces Initiation of a Phase II Clinical Trial of AGS-003 for the Treatment of Non-Small Cell Lung Cancer in Combination with Standard-of-Care Chemotherapy
Argos Therapeutics, Inc. announced the initiation of an investigator-sponsored Phase II clinical trial of AGS-003 in combination with standard platinum-doublet chemotherapy with or without radiation in patients with newly diagnosed stage 3 non-small cell lung cancer. [Argos Therapeutics, Inc.] Press Release

Vaxon Biotech Completes Enrolment of Phase IIb Lung Cancer Trial of First Therapeutic Vaccine Based on Optimized Cryptic Peptides
Vaxon Biotech announced the completion of enrolment for its Phase IIb trial of Vx-001 in non-small-cell lung cancer. [Vaxon Biotech (PipelineReview.com)] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cell Signaling in Cancer: From Mechanisms to Therapy
June 5-10, 2016
Snowmass Village, United States

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NEW PhD Studentships – Cancer Research (Cancer Research UK Manchester Institute)

NEW Postdoctoral Fellowship – Genomics (Brigham & Women’s Hospital – Harvard Medical School)

Postdoctoral Positions – Tissue Repair/Inflammation (Institut Pasteur)

Postdoctoral Position or Research Scientist – Mucosal Immunology (Qu Biologics)

Faculty Positions – Cancer Research (Texas Tech University Health Sciences Center)

Postdoctoral Fellow – Lung Cancer (The University of Texas MD Anderson Cancer Center)

Associate or Full Professor – Cardiothoracic Surgery (University of California San Diego)

Postdoctoral Research Fellow – Lung Cancer (Cornell University)

Postdoctoral Fellow – Lung Cancer Research (German Cancer Research Center)

Director Clinical Research – Medical Oncology (Fred Hutchinson Cancer Research Center)

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