Volume 5.02 | Jan 21

Pulmonary Cell News 5.02 January 21, 2016
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Mitochondrial Iron Chelation Ameliorates Cigarette Smoke–Induced Bronchitis and Emphysema in Mice
Scientists demonstrated that mice deficient in iron-responsive element–binding protein 2 (Irp2) were protected from cigarette smoke-induced experimental chronic obstructive pulmonary disease. By integrating RNA immunoprecipitation followed by sequencing, RNA sequencing, and gene expression and functional enrichment clustering analysis, they identified Irp2 as a regulator of mitochondrial function in the lungs of mice. [Nat Med] Abstract
Model the Human Respiratory Epithelium with PneumaCult™-ALI. Click to View Data.
 
PUBLICATIONS (Ranked by impact factor of the journal)
Glyoxalase I Drives Epithelial-to-Mesenchymal Transition via Argpyrimidine-Modified Hsp70, miR-21 and SMAD Signaling in Human Bronchial Cells BEAS-2B Chronically Exposed to Crystalline Silica Min-U-Sil 5: Transformation into a Neoplastic-Like Phenotype
Researchers investigated whether, and by means of which mechanism, the antiglycation defense glyoxalase I is involved in Min-U-Sil 5 crystalline silica-induced epithelial to mesenchymal transition in BEAS-2B human bronchial epithelial cells chronically exposed, and whether this is associated with the beginning of a neoplastic-like transformation process. [Free Radic Biol Med] Abstract

Protective Effect of Ac-SDKP on Alveolar Epithelial Cells through Inhibition of EMT via TGF-β1/ROCK1 Pathway in Silicosis in Rat
Investigators examined the effect of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) upon epithelial–mesenchymal transition (EMT) using an in vivo rat silicosis model, as well as in an in vitro model of TGF-β1-induced EMT. [Toxicol Appl Pharmacol] Abstract

SATB2 Expression Increased Anchorage-Independent Growth and Cell Migration in Human Bronchial Epithelial Cells
Researchers showed that ectopic expression of special AT-rich sequence-binding protein 2 (SATB2) in the normal human bronchial epithelial cell-line BEAS-2B increased anchorage-independent growth and cell migration, meanwhile, shRNA-mediated knockdown of SATB2 significantly decreased anchorage-independent growth in Ni transformed BEAS-2B cells. [Toxicol Appl Pharmacol] Abstract

Cadmium Induces Mucin 8 Expression via Toll-Like Receptor 4–Mediated Extracellular Signal Related Kinase 1/2 and p38 Mitogen-Activated Protein Kinase in Human Airway Epithelial Cells
The authors investigated the effect and the brief signaling pathway of cadmium on expression of mucin genes in human airway epithelial cells. In mucin-producing human NCI-H292 airway epithelial cells and primary cultures of normal nasal epithelial cells, the effect and signaling pathway of cadmium on expression of mucin genes were investigated. [Int Forum Allergy Rhinol] Abstract

Functional and Cytometric Examination of Different Human Lung Epithelial Cell Types as Drug Transport Barriers
Side-by-side experiments were performed to compare the structure and transport function of three lung epithelial cells. The cells were cultured on the nucleopore membranes in the air–liquid interface culture conditions, with cell culture medium in the basolateral side only, starting from day 1. [Arch Pharm Res] Abstract

LUNG CANCER

Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer
Scientists showed that polycomb repressive complex 2 (PRC2) is a critical regulator of KRAS-driven non-small cell lung cancer progression. Modulation of PRC2 by either Ezh2 overexpression or Eed deletion enhances KRAS-driven adenomagenesis and inflammation, respectively. [Cancer Cell] Abstract | Graphical Abstract

Tankyrase Inhibition Impairs Directional Migration and Invasion of Lung Cancer Cells by Affecting Microtubule Dynamics and Polarity Signals
Using a panel of lung cancer cell lines as a model system, scientists found that abrogation of tankyrase activity by two different, structurally unrelated small-molecule inhibitors or by RNA interference-based genetic silencing weakened cell migration, invasion, and directional movement induced by the motogenic cytokine hepatocyte growth factor. [BMC Biol] Full Article

Downregulation of miR-522 Suppresses Proliferation and Metastasis of Non-Small Cell Lung Cancer Cells by Directly Targeting DENN/MADD Domain Containing 2D
Investigators report that microRNA (miR)-522 expression was significantly increased in both human non-small cell lung cancer (NSCLC) tissues and cell lines. Furthermore, an MTT assay, 5-ethynyl-2′-deoxyuridine assay kit and flow cytometry confirmed that the inhibition of miR-522 suppressed NSCLC cells proliferation and induced apoptosis. [Sci Rep] Full Article

Interleukin-33 Enhances Programmed Oncosis of ST2L-Positive Low-Metastatic Cells in the Tumor Microenvironment of Lung Cancer
Researchers showed that ST2 was significantly downregulated in human lung cancer tissues and cells compared with normal lung tissues and cells. Interleukin-33 expression was also inversely correlated with the stages of human lung cancers. [Cell Death Dis] Full Article

Mucin 1-Mediated Chemo-Resistance in Lung Cancer Cells
The authors demonstrated that non-small cell lung cancers survive paclitaxel (PTX) treatment. Compared with the progenitor non-small cell lung cancer A549 cells, the PTX-resistant A549 cells displayed enhanced sphere-formation ability. [Oncogenesis] Full Article

Learn More: Standardized Tools for Cancer Research
 
REVIEWS
Long Noncoding RNAs: New Insights into Non-Small Cell Lung Cancer Biology, Diagnosis and Therapy
The authors conducted a comprehensive review focusing on long noncoding RNAs function and disruption in non-small cell lung cancer biology, also highlighting their value as biomarkers and potential therapeutic targets. [Med Oncol] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
INDUSTRY NEWS
MD Anderson, AbbVie Connect to Advance Cancer Immunotherapy
The immunotherapy platform at The University of Texas MD Anderson Cancer Center and AbbVie will join forces to find new ways to unleash the immune system’s potential to fight cancer. The three-year collaboration agreement provides a framework for MD Anderson and AbbVie to efficiently choose and carry out preclinical and clinical studies evaluating new ideas in the cutting-edge area of immuno-oncology. [AbbVie Inc.] Press Release

OncoGenex Announces Update on Phase II Spruce Trial in Previously Untreated Metastatic Non-Small Cell Lung Cancer
OncoGenex Pharmaceuticals, Inc. announced that data from the Phase II Spruce™ trial evaluating the combination of apatorsen with carboplatin and pemetrexed in patients with untreated metastatic non-small cell lung cancer did not reach the statistical significance required to demonstrate a progression-free survival benefit. [OncoGenex Pharmaceuticals, Inc.] Press Release

Center Will Develop Consistent Manufacturing Processes for Cell-Based Therapies
A $15.7 million grant from the Marcus Foundation has helped launch a new Georgia Institute of Technology research center that will develop processes and techniques for ensuring the consistent, low-cost, large-scale manufacture of high-quality living cells used in cell-based therapies. The therapies will be used for a variety of disorders such as cancer, lung fibrosis, autism, neuro-degenerative diseases, autoimmune disorders and spinal-cord injury – as well as in regenerative medicine. [Georgia Institute of Technology] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 3rd Immunotherapy of Cancer Conference (ITOC)
March 21-23, 2016
Munich, Germany

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Project Scientist – Pulmonary Fibrosis (Cedars Sinai Medical Center)

NEW PhD and MD/PhD Positions – Translational Pulmonary Medicine (Helmholtz Association)

NEW Postdoctoral Fellow – Bioinformatics RNA Biology & Cancer (German Cancer Research Center)

NEW Postdoctoral Fellow/Research Associate – Cancer Therapy (Memorial Sloan Kettering Cancer Center)

Director Clinical Research – Medical Oncology (Fred Hutchinson Cancer Research Center)

Postdoctoral Researcher – Immunology (Research Centre for Respiratory Diseases)

Postdoctoral Research Fellow – Epigenetics/Systems Biology (National Heart, Lung, and Blood Institute)

Postdoctoral Positions – Regenerative Biology and Medicine (Helmholtz Zentrum München)

Professor – Precision Cancer Medicine (German Cancer Research Center)

PhD Positions – Heart and Lung Research (Max Planck Institute for Heart and Lung Research)

Postdoctoral Positions – Lung Cancer Research (University of Texas)

PhD Studentships – Cancer and Allergy (University of Salzburg)


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