Volume 5.01 | Jan 14

Pulmonary Cell News 5.01 January 14, 2016
Pulmonary Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Lung Cell Found to Act as Sensor, Regulator of Immune Response
An uncommon and little-studied type of cell in the lungs has been found to act like a sensor, linking the pulmonary and central nervous systems to regulate immune response in reaction to environmental cues. The cells, known as pulmonary neuroendocrine cells, are implicated in a wide range of human lung diseases, including asthma, pulmonary hypertension, cystic fibrosis and sudden infant death syndrome, among others. [Press release from University of Wisconsin–Madison discussing online prepublication in Science] Press Release | Abstract
Video Protocol: Mucociliary Differentiation of Primary Bronchial Epithelial Cells
 
PUBLICATIONS (Ranked by impact factor of the journal)
Alda-1 Attenuates Lung Ischemia-Reperfusion Injury by Reducing 4-Hydroxy-2-Nonenal in Alveolar Epithelial Cells
A hypoxia/reoxygenation cell-culture model of human pulmonary alveolar epithelial cell, human pulmonary microvascular endothelial cell, and an isolated-perfused lung model were applied to mimic lung ischemia-reperfusion injury. [Crit Care Med] Abstract

Promotion of a Cancer-Like Phenotype, through Chronic Exposure to Inflammatory Cytokines and Hypoxia in a Bronchial Epithelial Cell Line Model
Given the recent successes of immune modulators in cancer therapy and the improved understanding of immune evasion by tumors, investigators sought to determine the carcinogenic impact of chronic TNF-α and IL‑1β exposure in a normal bronchial epithelial cell line model. [Sci Rep] Full Article

Lipopolysaccharide Induces ICAM-1 Expression via a c-Src/NADPH Oxidase/ROS-Dependent NF-κB Pathway in Human Pulmonary Alveolar Epithelial Cells
Researchers showed that lipopolysaccharide induced intercellular adhesion molecule-1 (ICAM-1) expression in human pulmonary alveolar epithelial cells, revealed by Western blotting, RT-PCR, real-time PCR, and promoter assay. [Am J Physiol Lung Cell Mol Physiol] Abstract

p53- and PAI-1-Mediated Induction of C-X-C Chemokines and CXCR2: Importance in Pulmonary Inflammation Due to Cigarette Smoke Exposure
Scientists showed increased expression of the C-X-C chemokines CXCL1 and CXCL2 and their receptor CXCR2, and the intercellular cellular adhesion molecule-1, in the lung tissues of patients with chronic obstructive pulmonary disease. They also found a similar increase in lung tissues and alveolar epithelial cells (AECs) from wild-type mice exposed to passive cigarette smoke (CS) for 20 weeks and in primary AECs treated with CS extract in vitro. [Am J Physiol Lung Cell Mol Physiol] Abstract

Comparison of the Anti-Inflammatory Effects of Proanthocyanidin, Quercetin, and Damnacanthal on Benzo(a)pyrene Exposed A549 Alveolar Cell Line
The authors investigated the potential curative effects of quercetin, damnacanthal, and proanthocyanidine on inflammatory mediators and oxidative stress parameters and to examine the viability of the A549 cell line treated with benzo(a)pyrene in vitro. [Inflammation] Abstract

LUNG CANCER

MUC5AC Interactions with Integrin β4 Enhances the Migration of Lung Cancer Cells through FAK Signaling
Researchers evaluated the mechanistic role of MUC5AC on metastasis of lung cancer cells. Functional studies showed that MUC5AC knockdown resulted in significantly decreased migration in two lung cancer cell lines as compared with scramble cells. [Oncogene] Abstract

CC Chemokine Ligand 18 (CCL18) Promotes Migration and Invasion of Lung Cancer Cells by Binding to Nir1 through Nir1-ELMO1/DOC180 Signaling Pathway
Investigators report that the high expression of CCL18 in M2-tumor associated macrophages (TAMs) of non-small cell lung cancer (NSCLC) tissues and increased expression of CCL18 in TAMs is correlated with the lymph node metastasis, distant metastasis, and poor prognosis NSCLC patients. CCL18 can increase the invasive ability of NSCLC cells by binding to its receptor Nir1. [Mol Carcinog] Abstract

Oroxylin A Inhibits Invasion and Migration through Suppressing ERK/GSK-3β Signaling in Snail-Expressing Non-Small-Cell Lung Cancer Cells
Researchers investigated the anti-invasive effect of oroxylin A on lung cells and uncovered its underlying mechanism. They suggested that oroxylin A could inhibit migration and invasion in Snail-expressing 95-D, and A549 cells whereas it had little effect on non-expressing GLC-82 cells. [Mol Carcinog] Abstract

Radiation-Induced miR-208a Increases the Proliferation and Radioresistance by Targeting p21 in Human Lung Cancer Cells
Scientists used microRNA (miRNA) microarray technology to identify serum miRNAs that were differentially expressed before and after radiotherapy in lung cancer patients. They further examined the biological function of miR-208a on cell viability, apoptotic death and cell cycle distribution in human lung cancer cells and explored the probable mechanism. [J Exp Clin Cancer Res] Full Article

Mucin 1-Mediated Chemo-Resistance in Lung Cancer Cells
The authors demonstrated that non-small cell lung cancers (NSCLCs) survive paclitaxel (PTX) treatment. Compared with the progenitor NSCLC A549 cells, the PTX-resistant A549 cells displayed enhanced sphere-formation ability. [Oncogenesis] Full Article

Watch Now: Webinar on Gastrointestinal Organoids by Dr. Meritxell Huch
 
REVIEWS
Matrix Remodeling in Pulmonary Fibrosis and Emphysema
The authors explore the concept that regulation of mesenchymal cells under the influence of soluble factors, in particular transforming growth factor-β1, and the extracellular matrix determine the divergent tissue remodeling responses seen in pulmonary fibrosis and emphysema. [Am J Respir Cell Mol Biol] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
SCIENCE NEWS
Xcovery Announces Updated Clinical Data on X-396 in Patients with ALK+ Non-Small Cell Lung Cancer
Xcovery announced updated clinical data on its investigational tyrosine kinase inhibitor, X-396, in patients with anaplastic lymphoma kinase (ALK+) advanced non-small cell lung cancer from an ongoing Phase I/II trial. [Press release from Xcovery discussing research presented at the 4th AACR-IASLC International Joint Conference 2016, San Diego] Press Release

From our sponsor: Learn about applications of ALDHbr cells in regenerative medicine. Watch the video.
 
INDUSTRY NEWS
ATCC Licenses CRISPR/Cas9 Technology from the Broad Institute
ATCC announced that it licensed CRISPR/Cas9 gene editing technology from the Broad Institute of MIT and Harvard. The first ATCC product developed using the licensed technology is the EML4-ALK Fusion-A549 Isogenic Cell Line. This cell line was derived from the parental A549 non-small cell lung cancer cell line, which is known as a work horse for in vitro and in vivo lung cancer research. [ATCC] Press Release

Gritstone Oncology Enters Into Exclusive Licensing Agreement and Collaboration with Memorial Sloan Kettering Cancer Center
Gritstone Oncology announced that the company has entered into an exclusive, worldwide licensing agreement and collaboration with Memorial Sloan Kettering Cancer Center. [Gritstone Oncology] Press Release

LUNGevity Foundation Now Accepting Applications for 2016 Career Development Awards for Translational Research
LUNGevity Foundation issued a request for applications for the 2016 Career Development Awards for Translational Research. These awards support innovative work by researchers in the first five years of their faculty appointment. [LUNGevity Foundation] Press Release
 
POLICY NEWS
GE Healthcare, FedDev Ontario Commit CAD $40 Million for New CCRM-Led Center to Solve Cell Therapy Manufacturing Challenges
GE Healthcare, the Federal Economic Development Agency for Southern Ontario (FedDev Ontario), and the Center for Commercialization of Regenerative Medicine (CCRM) are building a center for advanced therapeutic cell technologies in Toronto with an investment of $40 million from GE and FedDev Ontario. [Center for Commercialization of Regenerative Medicine] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW ESMO Symposium on Signaling Pathways in Cancer 2016: Focusing on the HER/EGFR Family Signaling
March 4-5, 2016
Sitges-Barcelona, Spain

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Director Clinical Research – Medical Oncology (Fred Hutchinson Cancer Research Center)

NEW Associate Service Fellow – Pulmonary Toxicologist/Pharmacologist (National Institute for Occupational Safety and Health)

Postdoctoral Researcher – Immunology (Research Centre for Respiratory Diseases)

Postdoctoral Research Fellow – Epigenetics/Systems Biology (National Heart, Lung, and Blood Institute)

Postdoctoral Positions – Regenerative Biology and Medicine (Helmholtz Zentrum München)

Postdoctoral Position – Molecular Cancer Cell Biology (Oslo University Hospital)

Professor – Precision Cancer Medicine (German Cancer Research Center)

PhD Positions – Heart and Lung Research (Max Planck Institute for Heart and Lung Research)

Postdoctoral Positions – Lung Cancer Research (University of Texas)

PhD Studentships – Cancer and Allergy (University of Salzburg)


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