Volume 5.00 | Jan 7

Pulmonary Cell News 5.00 January 7, 2016
Pulmonary Cell News
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Non-Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases
Scientists investigated the mechanisms by which human non-small cell lung cancer cells acquire resistance to alectinib. They established two alectinib-resistant cell lines that did not harbor the secondary anaplastic lymphoma kinase (ALK) mutations frequently occurring in crizotinib-resistant cells. [Cancer Res] Abstract
Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
PUBLICATIONS (Ranked by impact factor of the journal)
High Mobility Group Box 1-Induced Epithelial Mesenchymal Transition in Human Airway Epithelial Cells
Researchers used RNA sequencing to show that high mobility group box 1 treatment regulated epithelial–mesenchymal transition-related gene expression in human primary-airway epithelial cells. [Sci Rep] Full Article

Bixin Protects Mice against Ventilation-Induced Lung Injury in an NRF2-Dependent Manner
In vitro, bixin was found to activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 dependent manner; intraperitoneal injection of bixin led to pulmonary upregulation of the NRF2 response in vivo. [Sci Rep] Full Article

Mesenchymal Stem Cells Protect from Hypoxia-Induced Alveolar Epithelial-Mesenchymal Transition
The authors investigated whether human mesenchymal stem cells would prevent epithelial-mesenchymal transition induced by hypoxia in primary rat alveolar epithelial cells. [Am J Physiol Lung Cell Mol Physiol] Abstract

Aeroallergen Der p 2 Induces Apoptosis of Bronchial Epithelial BEAS-2B Cells via Activation of Both Intrinsic and Extrinsic Pathway
Investigators showed that recombinant Der p 2 inhibited cell growth and induced apoptosis of human bronchial epithelial cell BEAS-2B. [Cell Biosc] Full Article

KCa3.1 K+ Channel Expression and Function in Human Bronchial Epithelial Cells
Researchers assessed whether primary human bronchial epithelial cells (HBECs) express the KCa3.1 channel and its role in HBEC function. Primary HBECs from the airways of healthy and asthmatic subjects, SV-transformed BEAS-2B cells and the neoplastic H292 epithelial cell line were studied. [PLoS One] Full Article

Brominated Flame Retardants, Hexabromocyclododecane and Tetrabromobisphenol A, Affect Proinflammatory Protein Expression in Human Bronchial Epithelial Cells via Disruption of Intracellular Signaling
Hexabromocyclododecane exposure significantly increased the expression of intercellular adhesion molecule-1 and the production of interleukin-6 and -8 in human bronchial epithelial cells. [Toxicol In Vitro] Abstract


Synergistic Killing of Human Small Cell Lung Cancer Cells by the Bcl-2-Inositol 1,4,5-Trisphosphate Receptor Disruptor BIRD-2 and the BH3-Mimetic ABT-263
Scientists report for the first time that Bcl-2-IP3 receptor disruptor-2 (BIRD-2), a decoy peptide that binds to the BH4 domain of Bcl-2 and prevents Bcl-2 interaction with inositol 1,4,5-trisphosphate receptors, induces cell death in a wide range of small cell lung cancer lines, including ABT-263-resistant lines. [Cell Death Dis] Full Article

Expression of MicroRNA-452 via Adenoviral Vector Inhibits Non-Small Cell Lung Cancer Cells Proliferation and Metastasis
The authors identified how miR-452 acts in regulating non-small cell lung cancer (NSCLC) proliferation and metastasis. Expression of miR-452 via adenoviral vector inhibits the proliferation, invasion, and migration of NSCLC cells A549 or H460. [Tumor Biol] Abstract

The Attenuation of Epithelial to Mesenchymal Transition and Induction of Anoikis by Gigantol in Human Lung Cancer H460 Cells
Investigators demonstrated for the first time that gigantol significantly decreases lung cancer cells’ viability in a detached condition through anoikis and anchorage-independent assays. [Tumor Biol] Abstract

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Organoids as a Model System for Studying Human Lung Development and Disease
The authors summarize the organoid-forming capacity of respiratory cells, current lung organoid technologies and their potential use in future therapeutic applications. [Biochem Biophys Res Commun] Abstract

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Afatinib a Better Choice for EGFR-Mutated Lung Cancer in First-Line Treatment
Patients with EGFR-activating mutations in advanced lung cancer seem to benefit more from afatinib than gefitinib as first-line treatment, researchers report. [Press release from European Society for Medical Oncology (ESMO) (PR Newswire Association LLC) discussing research presented at the ESMO Asia 2015 Congress, Singapore] Press Release

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Boehringer Ingelheim 3rd-Generation EGFR TKI, BI 1482694, Receives FDA Breakthrough Therapy Designation in Lung Cancer
Boehringer Ingelheim announced that the US Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation for its novel, 3rd-generation, epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor (TKI), BI 1482694. [Boehringer Ingelheim GmbH] Press Release

OSE Pharma Announces Initiation of Its Pivotal Phase III Trial of Tedopi® in Non-Small Cell Lung Cancer
OSE Pharma SA announced the initiation of its registration clinical trial named “Atalante 1”. This trial evaluates Tedopi®, the company’s lead product for advanced non-small cell lung cancer. [OSE Pharma SA (Business Wire)] Press Release

Mirati Therapeutics Initiates Glesatinib (MGCD265) Phase II Trial In Non-Small Cell Lung Cancer (NSCLC)
Mirati Therapeutics, Inc. announced that the Phase II clinical trial of glesatinib has commenced. [Mirati Therapeutics, Inc.] Press Release

Merrimack Amends MM-121 Phase II Clinical Study in Heregulin-Positive Non-Small Cell Lung Cancer to Support Potential Registration
Merrimack Pharmaceuticals, Inc. announced it filed an amendment to its ongoing Phase II clinical study of MM-121 in patients with heregulin-positive non-small cell lung cancer with the U.S. Food and Drug Administration. [Merrimack Pharmaceuticals, Inc.] Press Release
World’s First Clinical Guidelines for Chronic Fungal Lung Infections
The world’s first guidelines for chronic fungal lung infections for doctors and laboratories have been published by the European Respiratory Society and the European Society of Clinical Microbiology and Infectious Diseases. These new guidelines describe the important features of this disease and provide comprehensive treatment recommendations. [European Lung Foundation] Editorial | Article

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW The Controlling Cancer Summit 2016
May 17-19, 2016
London, United Kingdom

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NEW Postdoctoral Researcher – Immunology (Research Centre for Respiratory Diseases)

NEW Postdoctoral Research Fellow – Epigenetics/Systems Biology (National Heart, Lung, and Blood Institute)

NEW Postdoctoral Positions – Regenerative Biology and Medicine (Helmholtz Zentrum München)

NEW Postdoctoral Position – Molecular Cancer Cell Biology (Oslo University Hospital)

Professor – Precision Cancer Medicine (German Cancer Research Center)

PhD Positions – Heart and Lung Research (Max Planck Institute for Heart and Lung Research)

Postdoctoral Positions – Lung Cancer Research (University of Texas)

PhD Studentships – Cancer and Allergy (University of Salzburg)

Investigator – Cancer Biology (Wake Forest Baptist School of Medicine)

Postdoctoral Fellow – Cancer Biology (Cold Spring Harbor Laboratory)

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