Volume 4.48 | Dec 10

Pulmonary Cell News 4.48 December 10, 2015
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Targeting Ceramide Synthase 6–Dependent Metastasis-Prone Phenotype in Lung Cancer Cells
Researchers analyzed non–small-cell lung cancer specimens and cell lines and determined that ceramide synthase 6 (CERS6) is markedly overexpressed compared with controls. Elevated CERS6 expression was due in part to reduction of microRNA-101 and was associated with increased invasion and poor prognosis. [J Clin Invest] Full Article
Video Protocol: Mucociliary Differentiation of Primary Bronchial Epithelial Cells
 
PUBLICATIONS (Ranked by impact factor of the journal)
Transcription Factor Runx3 Is Induced by Influenza A Virus and Double-Strand RNA and Mediates Airway Epithelial Cell Apoptosis
Scientists found for the first time that transcription factor Runx3, a developmental regulator and tumor suppressor, was induced by influenza A virus H1N1 and H3N2, viral RNA, a synthetic analog of viral double-stranded RNA polyinosinic-polycytidylic acid, and type-II interferon-γ in human airway epithelial cells. [Sci Rep] Full Article

Integrative Transcriptomic and Protein Analysis of Human Bronchial BEAS-2B Exposed to Seasonal Urban Particulate Matter
Human bronchial epithelial cells were used to analyze the pathways activated after exposure to summer and winter urban particulate matter and to identify possible markers of exposure. [Environ Pollut] Abstract

Angiotensin 1-7/Mas Inhibits Apoptosis in Alveolar Epithelial Cells through Upregulation of Map Kinase Phosphatase-2
It was theorized that angiotensin 1-7 activates a map kinase phosphatase and thereby reduces JNK phosphorylation to inhibit apoptosis and promote cell survival. This hypothesis was evaluated in the human A549 and mouse MLE12 alveolar epithelial cell (AEC) lines and primary cultures of human AECs. [Am J Physiol Lung Cell Mol Physiol] Abstract

Aspirin Inhibits LPS-Induced Expression of PI3K/Akt, ERK, NF-κB, CX3CL1, and MMPs in Human Bronchial Epithelial Cells
The authors focused on the effects of aspirin on lipopolysaccharide (LPS)-induced expression of phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt), extracellular signal-regulated protein kinase (ERK), nuclear factor-κB (NF-κB), CX3CL1, and MMPs in human bronchial epithelial cells. [Inflammation] Abstract

Induction of the Matrix Metalloproteinase 13 Gene in Bronchial Epithelial Cells by Interferon and Identification of its Novel Functional Polymorphism
Researchers investigated the mechanisms and roles of matrix metalloproteinase 13 (MMP-13) secretion in human small airway epithelial cells and functional polymorphisms of the MMP13 gene. [Inflammation] Abstract

LUNG CANCER

Resveratrol Overcomes Gefitinib Resistance by Increasing the Intracellular Gefitinib Concentration and Triggering Apoptosis, Autophagy and Senescence in PC9/G NSCLC Cells
Investigators demonstrated that resveratrol could synergize with gefitinib (Gef) to inhibit the proliferation of Gef-resistant non-small cell lung cancer (NSCLC) cells. [Sci Rep] Full Article

miR-512-5p Induces Apoptosis and Inhibits Glycolysis by Targeting p21 in Non-Small Cell Lung Cancer Cells
Overexpression of miR-512-5p induced apoptosis of non-small cell lung cancer (NSCLC) cell lines A549 and H1299, and miR-512-5p inhibitor reversed this effect in H1299 cells stably expressing miR-512. miR-512-5p inhibited glycolysis and migration in NSCLC cells, but shows no effect on cell proliferation. [Int J Oncol] Abstract

Targeting of Carbon Ion-Induced G2 Checkpoint Activation in Lung Cancer Cells Using Wee-1 Inhibitor MK-1775
The authors investigated the effects of carbon ions in combination with MK-1775 on the killing of non-small cell lung cancer cells. [Radiat Res] Abstract

Learn More: Standardized Tools for Cancer Research
 
REVIEWS
Control of Local Immunity by Airway Epithelial Cells
Scientists discuss epithelial cell regulatory functions that control reactivity of professional immune cells within the microenvironment of the airways and how these mechanisms are altered in pulmonary diseases. [Mucosal Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
INDUSTRY NEWS
New Phase III Study of Nintedanib in People with Systemic Sclerosis and Lung Fibrosis
Boehringer Ingelheim announced that the first person has been enrolled in the SENSCIS™ study. The global Phase III trial, which is now open for recruitment, is investigating the efficacy and safety of nintedanib in people with a rare disease called systemic sclerosis who also developed interstitial lung disease. [Boehringer Ingelheim GmbH] Press Release

Cuban Cancer Vaccine Extended to Policlinics
The Cuban CIMAVAX EGF therapeutic vaccine produced in the Molecular Engineering Center has begun new clinical testing against lung cancer in policlinics throughout the country. [Molecular Engineering Center (Cuban News Agency)] Press Release

Pfizer Announces U.S. FDA Acceptance and Priority Review of Supplemental New Drug Application for XALKORI® for the Treatment of Patients with ROS1-Positive Metastatic Non-Small Cell Lung Cancer
Pfizer Inc. announced that the U.S. Food and Drug Administration (FDA) has accepted and granted Priority Review for a supplemental New Drug Application for XALKORI® for the treatment of patients with metastatic non-small cell lung cancer whose tumors are ROS1-positive. [Pfizer Inc.] Press Release

Biothera Announces Clinical Study to Evaluate Combination Therapy of Imprime PGG and Merck’s Checkpoint Inhibitor Keytruda in Patients with Non-Small Cell Lung Cancer
Biothera Pharmaceutical Inc. announced plans for a Phase Ib/II clinical study in non-small lung cancer patients to evaluate the ability of Biothera’s Imprime PGG to enhance responses to pembrolizumab, the anti-PD-1 antibody from Merck. [Biothera Pharmaceutical Inc.] Press Release

From our sponsor: Culturing hematopoietic stem and progenitor cells? Download the technical bulletin.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Cancer as an Evolving and Systemic Disease
March 12-15, 2016
New York City, United States

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW PhD Positions – Heart and Lung Research (Max Planck Institute for Heart and Lung Research)

Postdoctoral Positions – Lung Cancer Research (University of Texas)

Postdoctoral Scientist (Bioinformatician) – Clinical and Experimental Pharmacology (Cancer Research UK Manchester Institute)

PhD Studentships – Cancer and Allergy (University of Salzburg)

Investigator – Cancer Biology (Wake Forest Baptist School of Medicine)

Postdoctoral Fellow – Cancer Biology (Cold Spring Harbor Laboratory)

Postdoctoral Positions – Fibrotic Remodeling of the Lung (University of Vermont)

Postdoctoral Positions – Cancer (University of Texas MD Anderson Cancer Center)

Post-Doctoral Fellow – Lung Microbiome Research and Asthma (University of Michigan)

Postdoctoral Fellowship – Developmental Cell Biology and Regenerative Medicine (University of California San Francisco)


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