Volume 4.47 | Dec 3

Pulmonary Cell News 4.47 December 3, 2015
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Scientists Find Protein ‘Talks’ to Wrong Partners in Cystic Fibrosis
Scientists have found evidence that a mutant protein responsible for most cases of cystic fibrosis is so busy “talking” to the wrong cellular neighbors that it cannot function normally and is prematurely degraded. [Press release from The Scripps Research Institute discussing online prepublication in Nature]
Press Release | Abstract
Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
 
PUBLICATIONS (Ranked by impact factor of the journal)
IL-27 Enhances Innate Immunity of Human Pulmonary Fibroblasts and Epithelial Cells through Upregulation of TLR4 Expression
Investigators examined the immunopathological mechanisms for the activation of primary human lung fibroblasts and bronchial epithelial cells by IL-27. They demonstrated that IL-27 priming enhanced LPS-induced production of IL-6 and IL-8 from lung fibroblasts and bronchial epithelial cells via up-regulating TLR4 expression. [Am J Physiol Lung Cell Mol Physiol] Abstract

Aryl Hydrocarbon Receptor-Dependent Up-Regulation of the Heterodimeric Amino Acid Transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by Diesel Exhaust Particle Extract in Human Bronchial Epithelial Cells
Researchers analyzed the effects of diesel exhaust particle extract (DEPe) on LAT1/CD98hc expression in bronchial epithelial BEAS-2B cells. Exposure to DEPe up-regulated LAT1 and CD98hc mRNA levels in a concentration-dependent manner, with DEPe EC50 values relevant to environmental situations. [Toxicol Appl Pharmacol] Abstract

Interferon Response of the Cystic Fibrosis Bronchial Epithelium to Major and Minor Group Rhinovirus Infection
Scientists assessed the antiviral response of cystic fibrosis and healthy bronchial epithelial cells to rhinovirus (RV) infection. They measured the levels of interferons (IFNs), pattern recognition receptors and IFN-stimulated genes upon infection with major and minor group RVs and poly(IC) stimulation. [J Cyst Fibros] Abstract

Comparison of Innate Immune Responses towards Rhinovirus Infection of Primary Nasal and Bronchial Epithelial Cells
Researchers used primary paired nasal epithelial cell and bronchial epithelial cell cultures established from healthy subjects and compared the replication of rhinoviruses belonging to the major and minor group, and the cellular antiviral and proinflammatory cytokine responses towards these viruses. [Respirology] Abstract

LUNG CANCER

Dasatinib Induces DNA Damage and Activates DNA Repair Pathways Leading to Senescence in Non-Small Cell Lung Cancer Cell Lines with Kinase-Inactivating BRAF Mutations
No canonical pathways explain dasatinib-induced senescence in kinase-inactivating BRAF mutations (KIBRAF) non-small cell lung cancer (NSCLC). To investigate the underlying mechanism, scientists used two approaches: gene expression and reverse phase protein arrays. Both approaches showed that DNA repair pathways were differentially modulated between KIBRAF NSCLC cells and those with wild-type BRAF. [Oncotarget] Full Article

miR-181b Regulates Cisplatin Chemosensitivity and Metastasis by Targeting TGFβR1/Smad Signaling Pathway in NSCLC
The authors identified miR-181b and its mechanism in the chemosensitivity and metastasis of non-small cell lung cancer (NSCLC). They found that miR-181b expression levels were lower in A549/DDP cells compared with A549 cells. [Sci Rep] Full Article

Quercetin Inhibits Multiple Pathways Involved in Interleukin 6 Secretion from Human Lung Fibroblasts and Activity in Bronchial Epithelial Cell Transformation Induced by Benzo[a]Pyrene Diol Epoxide
The authors showed that benzo[a]pyrene diol epoxide-induced human bronchial epithelial cell transformation was enhanced by interleukin 6 in vitro. [Mol Carcinog] Abstract

CD44 Is Functionally Crucial for Driving Lung Cancer Stem Cells Metastasis through Wnt/β-Catenin-FoxM1-Twist Signaling
Scientists found that CD133+CD44+ cells which were derived from primary lung adenocarcinoma possessed cancer stem cell-like features. Furthermore, CD44 was demonstrated functionally crucial to drive metastatic potential of CD133+CD44+ lung cancer stem cell-like cells by in vitro and in vivo experiments. [Mol Carcinog] Abstract

Study of Bioreductive Anticancer Agent RH-1-Induced Signals Leading the Wild-Type p53-Bearing Lung Cancer A549 Cells to Apoptosis
Researchers investigated the involvement of different signaling molecules in cytotoxicity induced by RH-1 by using wild-type tumor suppressor p53-bearing non-small cell lung carcinoma A549 cells as a model. [Chem Res Toxicol] Abstract

Learn More: Model the Human Airway at the Air-Liquid Interface
 
REVIEWS
Clinical Potential of Gene Mutations in Lung Cancer
The authors explore the clinical potential of non-small cell lung cancer (NSCLC) genetic studies on diagnosing and treating NSCLC. [Clin Transl Med] Full Article

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
INDUSTRY NEWS
Adaptimmune Initiates Phase I/II Trial Evaluating Its Affinity Enhanced T-Cell Therapy Targeting
Adaptimmune Therapeutics plc announced that it has initiated a study of its affinity enhanced T-cell therapy targeting the NY-ESO-1 cancer antigen in patients with Stage IIIb or Stage IV non-small cell lung cancer. [Adaptimmune Therapeutics plc] Press Release

NCCN Collaborates with Bristol-Myers Squibb to Study PD-L1 Expression and Test Interpretation in Lung Cancer
To improve the scientific knowledge concerning PD-L1 protein expression and help pathologists understand the diagnostic nuances associated with lung cancer treatment, the National Comprehensive Cancer Network® (NCCN®) Oncology Research Program and Bristol-Myers Squibb (BMS) are collaborating on the NCCN/BMS Thoracic Pathology Protocol Development Team. [National Comprehensive Cancer Network®] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Keystone Symposia – Stem Cells and Cancer
March 6-10, 2016
Breckenridge, United States

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Positions – Lung Cancer Research (University of Texas)

NEW Postdoctoral Scientist (Bioinformatician) – Clinical and Experimental Pharmacology (Cancer Research UK Manchester Institute)

PhD Studentships – Cancer and Allergy (University of Salzburg)

Investigator – Cancer Biology (Wake Forest Baptist School of Medicine)

Postdoctoral Fellow – Cancer Biology (Cold Spring Harbor Laboratory)

Postdoctoral Positions – Fibrotic Remodeling of the Lung (University of Vermont)

Postdoctoral Positions – Cancer (University of Texas MD Anderson Cancer Center)

Post-Doctoral Fellow – Lung Microbiome Research and Asthma (University of Michigan)

Postdoctoral Fellowship – Developmental Cell Biology and Regenerative Medicine (University of California San Francisco)

Postdoctoral Researcher – Molecular Mechanisms of Pulmonary Diseases (Eastern Virginia Medical School)


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