Volume 4.43 | Nov 5

Pulmonary Cell News 4.43 November 5, 2015
Pulmonary Cell News
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Telomerase Deficiency Causes Alveolar Stem Cell Senescence-Associated Low-Grade Inflammation in Lungs
Researchers showed that knockout of the mouse gene telomerase RNA component or telomerase reverse transcriptase causes pulmonary alveolar stem cell replicative senescence, epithelial impairment, formation of alveolar sacs, and characteristic inflammatory phenotype. [J Biol Chem] Abstract | Full Article
Video Protocol: Mucociliary Differentiation of Primary Bronchial Epithelial Cells
PUBLICATIONS (Ranked by impact factor of the journal)
E-Cigarette Affects the Metabolome of Primary Normal Human Bronchial Epithelial Cells
Scientists assessed the changes of the intracellular metabolome upon treatment with e-cigarette liquid in comparison of the effect of cigarette smoke condensate with mass spectrometry and principal component analysis on air-liquid interface model of normal human bronchial epithelial cells. [PLoS One] Full Article

Roflumilast Partially Reverses Smoke-Induced Mucociliary Dysfunction
The authors showed that roflumilast can rescue smoke-induced mucociliary dysfunction by reversing decreased cystic fibrosis transmembrane conductance regulator activity, augmenting airway surface liquid volume, and stimulating ciliary beat frequency, the latter particularly in combination with formoterol. [Respir Res] Full Article

Development of an In Vitro Test to Identify Respiratory Sensitizers in Bronchial Epithelial Cells Using Gene Expression Profiling
To elucidate potential molecular effects of exposure of the epithelial lung barrier, a gene expression profile was created based on a DNA microarray experiment using the bronchial epithelial cell line 16HBE14o. The cells were exposed to 12 respiratory sensitizers and 10 non-sensitizers. [Toxicol In Vitro] Abstract


RASSF4 Is Downregulated in Non-Small Cell Lung Cancer and Inhibits Cancer Cell Proliferation and Invasion
Scientists examined RASSF4 protein expression in normal lung epithelial cell line and lung cancer lines. They found that RASSF4 expression was downregulated in four of seven lung cancer cell lines compared with normal bronchial epithelial cells. [Tumor Biol] Abstract

Rapamycin Inhibited the Function of Lung CSCs via SOX2
Investigators showed that rapamycin inhibited the mammalian target of rapamycin signal transduction in A549 cells and improved the sensitivity to cisplatin. The mechanisms involved inhibition of the SOX2 expression, cell proliferation, epithelial-mesenchymal transition phenotype, and sphere formation. [Tumor Biol] Abstract

Effect of ABCG2/BCRP Expression on Efflux and Uptake of Gefitinib in NSCLC Cell Lines
The authors indicate that gefitinib, in lung cancer cells, inhibits ABCG2 activity, as previously reported. In addition, they suggest that ABCG2 silencing or overexpression affects intracellular gefitinib content by modulating the uptake rather than the efflux. [PLoS One] Full Article

Curcumin Improves the Efficacy of Cisplatin by Targeting Cancer Stem-Like Cells through p21 and Cyclin D1-Mediated Tumor Cell Inhibition in Non-Small Cell Lung Cancer Cell Lines
Scientists showed that curcumin enhanced the sensitivity of the double-positive cancer stem-like cell subpopulation in non-small cell lung cancer cell lines to cisplatin-induced apoptosis and inhibition of metastasis. [Oncol Rep] Abstract | Download Full Article

β-Elemonic Acid Inhibits the Cell Proliferation of Human Lung Adenocarcinoma A549 Cells: The Role of MAPK, ROS Activation and Glutathione Depletion
Researchers investigated the anticancer effects and the related molecular mechanisms of β-elemonic acid on human non-small cell lung cancer A549 cells. The effects of β-elemonic acid on the growth of A549 cells were studied using a 3-(4,5)-2,5-diphenyltetrazolium bromide assay. [Oncol Rep] Abstract

Learn More: Model the Human Airway at the Air-Liquid Interface
Immunotherapy for Non-Small Cell Lung Cancer: Current Concepts and Clinical Trials
The authors summarize concepts and the current status of immunotherapy for non-small cell lung cancer, including salient features of the major categories of immunotherapy—monoclonal antibody therapy, immune checkpoint blockade, immunotoxins, anticancer vaccines, and adoptive cell therapy. [Eur J Cardiothorac Surg] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
Genocea Announces Immuno-Oncology Research Collaboration with Memorial Sloan Kettering Cancer Center
Genocea Biosciences, Inc. announced a collaboration with Memorial Sloan Kettering Cancer Center to screen the T cell responses of melanoma and non-small cell lung cancer patients treated with checkpoint inhibitors against the complete repertoire of patient-specific putative cancer neoantigens. [Genocea Biosciences, Inc.] Press Release

Merck KGaA, Darmstadt, Germany, and Pfizer Announce Initiation of Phase III First-Line Trial of Avelumab in Patients with Recurrent or Stage IV Non-Small Cell Lung Cancer
Merck KGaA and Pfizer announced the initiation of an international Phase III study of the investigational cancer immunotherapy avelumab in a treatment naïve advanced non-small cell lung cancer setting. [Pfizer (Business Wire)] Press Release

Boehringer Ingelheim Initiates Pivotal Programme for Novel Third-Generation EGFR Targeting Lung Cancer Compound
Boehringer Ingelheim announced the initiation of a global Phase II trial evaluating the efficacy and safety of BI 1482694 in patients with T790M mutation-positive non-small cell lung cancer, whose tumours stopped responding to currently available epidermal growth factor receptor (EGFR) directed therapies. [Boehringer Ingelheim GmbH] Press Release

Immunovaccine’s Vaccine Candidate for Respiratory Syncytial Virus Is Well Tolerated in Volunteers in Phase I Clinical Trial
Immunovaccine Inc. announced that safety data from a Phase I clinical study showed that its DepoVax™ prophylactic respiratory syncytial virus vaccine candidate (DPX-RSV) was well tolerated in the Phase I study’s first 20 volunteers, of whom 8 subjects received the DPX-RSV vaccine. [Immunovaccine Inc.] Press Release

GSK and Merck to Study Immunotherapy Combination as Potential Cancer Treatment
GSK and Merck announced the initiation of a Phase I clinical trial designed to evaluate GSK’s investigational immunotherapy GSK3174998 as monotherapy and in combination with Merck’s anti-PD-1 therapy, Keytruda® in patients with locally advanced, recurrent or metastatic solid tumor(s) that have progressed after standard treatment. [GlaxoSmithKline plc] Press Release

First Patient Dosed in Clinical Trial of Halozyme Investigational Drug PEGPH20 in Combination with Merck Immuno-Oncology Drug KEYTRUDA
Halozyme Therapeutics, Inc. announced the first patient has received its investigational new drug, PEGPH20 in combination with Merck’s KEYTRUDA in a clinical trial to determine the maximum tolerated dose of PEGPH20 and antitumor activity of the combined therapies. [Halozyme Therapeutics, Inc.] Press Release

FDA Approves New Novartis Dual Combination Bronchodilator Utibron™ Neohaler® for Patients with Chronic Obstructive Pulmonary Disease
Novartis announced that the US Food and Drug Administration (FDA) has approved the dual combination bronchodilator Utibron™ Neohaler® inhalation powder for the long-term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease, including chronic bronchitis and/or emphysema. [Novartis Pharmaceuticals Corporation] Press Release

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Canada Creates Science-Minister Post
Canada’s new prime minister, Justin Trudeau, created the post of Minister of Science as one of his first acts. Kirsty Duncan, a medical geographer at the University of Toronto, will be the first to hold the job. [Nature News] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 28th Lorne Cancer Conference
February 11-13, 2016
Lorne, Australia

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Postdoctoral Positions – Fibrotic Remodeling of the Lung (University of Vermont)

NEW Postdoctoral Positions – Cancer (University of Texas MD Anderson Cancer Center)

NEW Post-Doctoral Fellow – Lung Microbiome Research and Asthma (University of Michigan)

PhD Studentships – Cancer Research (University of Cambridge)

Postdoctoral Position – Pulmonary Research (Helmholtz Association)

Postdoctoral Position – Lung Biology Research (University of Southern California)

Postdoctoral Fellowship – Developmental Cell Biology and Regenerative Medicine (University of California San Francisco)

Postdoctoral Researcher – Molecular Mechanisms of Pulmonary Diseases (Eastern Virginia Medical School)

Postdoctoral Fellow – Asthma (The University of Tennessee Health Science Center)

Postdoctoral Research Fellow – Small Cell Lung Cancer (Fred Hutchinson Cancer Research Center)

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