Volume 4.42 | Oct 29

Pulmonary Cell News 4.42 October 29, 2015
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Mucosal Production of Uric Acid by Airway Epithelial Cells Contributes to Particulate Matter-Induced Allergic Sensitization
Scientists investigated the mechanisms behind particulate matter-induced allergic sensitization in the context of lung mucosal uric acid. They then demonstrated that human airway epithelial cells secrete uric acid basally and after stimulation through a previously unidentified mucosal secretion system. [Mucosal Immunol] Abstract
Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
 
PUBLICATIONS (Ranked by impact factor of the journal)
Agonist Binding to β-Adrenergic Receptors on Human Airway Epithelial Cells Inhibits Migration and Wound Repair
Impedance sensing arrays were used to measure cell migration and epithelial restitution following wounding of confluent normal human bronchial epithelial cells and Calu-3 cells by electroporation. [Am J Physiol Cell Physiol] Abstract

Epigenetic Silencing of p21 by Long Non-Coding RNA HOTAIR Is Involved in the Cell Cycle Disorder Induced by Cigarette Smoke Extract
Scientists report that increased expression of Hox transcript antisense intergenic RNA (HOTAIR) and enhancer of zeste homolog 2, and tri-methylation of Lys 27 of histone H3, affect cell cycle progression during cigarette smoke extract-induced transformation of human bronchial epithelial cells. [Toxicol Lett] Abstract

Interleukin-17A and Toll-Like Receptor 3 Ligand Poly(I:C) Synergistically Induced Neutrophil Chemoattractant Production by Bronchial Epithelial Cells
Investigators assessed chemokine production by bronchial epithelial cells and investigated the underlying mechanisms. Comprehensive chemokine analysis showed that, compared with poly(I:C) alone, co-stimulation of BEAS-2B cells with interleukin-17A and poly(I:C) strongly induced production of such neutrophil chemoattractants as CXC chemokine ligand (CXCL)8, growth-related oncogene, and CXCL1. [PLoS One] Full Article

HO-1 Inhibits IL-13-Induced Goblet Cell Hyperplasia Associated with CLCA1 Suppression in Normal Human Bronchial Epithelial Cells
Researchers examined the effects of heme oxygenase-1 (HO-1) on mucin production and goblet cell hyperplasia induced by IL-13. Moreover, they assessed the cell signaling intermediates that appear to be responsible for mucin production. Normal human bronchial epithelial cells were grown at air liquid interface in the presence or absence of IL-13 and hemin, a HO-1 inducer, for 14 days. [Int Immunopharmacol] Abstract

LUNG CANCER

NLK Functions to Maintain Proliferation and Stemness of NSCLC and Is a Target of Metformin
Researchers investigated a novel role of Nemo-like kinase (NLK) and metformin in human non-small cell lung cancer (NSCLC). Lentivirus vectors with NLK-shRNA were used to examine the effect of NLK on cell proliferation and tumorigenesis in vitro. [J Hematol Oncol] Full Article

MARVELD1 Modulates Cell Surface Morphology and Suppresses Epithelial–Mesenchymal Transition in Non-Small Cell Lung Cancer
The authors found MARVELD1 silencing altered cell surface ultrastructure of non-small cell lung cancer cells and inhibited the formation of punctate integrin β1/β4 cluster in microvillus, whereas MARVELD1 overexpression suppressed TGF-β1-induced epithelial–mesenchymal transition. [Mol Carcinog] Abstract

Overexpression of HPV16 E6/E7 Mediated HIF-1α Upregulation of GLUT1 Expression in Lung Cancer Cells
Investigators evaluated the underlying molecular mechanism that HPV16 regulate the expression of GLUT1 and may promote the development of lung cancer. HPV16, HIF-1α, and GLUT1 were detected in pleural effusions of patients with lung cancer and with benign lung disease by immunocytochemistry. [Tumor Biol] Abstract

Sanguiin H6 Suppresses TGF-β Induction of the Epithelial–Mesenchymal Transition and Inhibits Migration and Invasion in A549 Lung Cancer
To understand the inhibitory effects of sanguiin H6 on lung cancer migration and invasion, the authors investigated the ability of sanguiin H6 to inhibit transforming growth factor-beta 1 (TGF-β1)-induced epithelial–mesenchymal transition in the A549 cell line. [Bioorg Med Chem Lett] Abstract

HuR-Targeted Nanotherapy in Combination with AMD3100 Suppresses CXCR4 Expression, Cell Growth, Migration and Invasion in Lung Cancer
Scientists treated human H1299 lung cancer cells with HuR-specific siRNA contained in a folate-targeted lipid nanoparticle (HuR-FNP) plus AMD3100, and compared this with AMD3100 alone, HuR-FNP alone and no treatment. HuR-FNP plus AMD3100 treatment produced a G1 phase cell cycle arrest and reduced cell viability above and beyond the effects of AMD3100 alone. [Cancer Gene Ther] Abstract

Watch Now: Webinar on Gastrointestinal Organoids by Dr. Meritxell Huch
 
REVIEWS
CRISPR/Cas9: Molecular Tool for Gene Therapy to Target Genome and Epigenome in the Treatment of Lung Cancer
This review frames utilization of CRISPR/Cas9 for molecular targeted gene therapy leading to long-term repression and activation or inhibition of molecular targets linked to lung cancer, avoiding the cycles of therapy. [Cancer Gene Ther] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
INDUSTRY NEWS
Merck’s KEYTRUDA® (Pembrolizumab) Shows Superior Overall Survival Compared to Chemotherapy in Patients with Previously Treated Advanced Non-Small Cell Lung Cancer Whose Tumors Express PD-L1
Merck announced topline results from the KEYNOTE-010 study of KEYTRUDA® in advanced non-small-cell lung cancer demonstrating that the trial met its primary objective. [Merck & Co., Inc.] Press Release

OrPro Therapeutics Receives US Patent Covering Novel Enzymatic Treatment for Cystic Fibrosis
OrPro Therapeutics, Inc. announced that the US Patent and Trademark Office has issued U.S. Patent No. 9,168,290 covering the ability of Theradux™ to improve the viscoelastic properties of mucus secretions in patients with diseases characterized by excessively viscous or cohesive mucus or sputum, such as cystic fibrosis and other obstructive lung diseases. [OrPro Therapeutics, Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Cell Culture 2016
February 2-4, 2016
London, United Kingdom

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW PhD Studentships – Cancer Research (University of Cambridge)

Postdoctoral Position – Pulmonary Research (Helmholtz Association)

Postdoctoral Position – Lung Biology Research (University of Southern California)

Postdoctoral Fellowship – Developmental Cell Biology and Regenerative Medicine (University of California San Francisco)

Postdoctoral Researcher – Molecular Mechanisms of Pulmonary Diseases (Eastern Virginia Medical School)

Postdoctoral Fellow – Asthma (The University of Tennessee Health Science Center)

Postdoctoral Scholar – Autoimmune Diseases Affecting the Lung (University of California, San Francisco)

Postdoctoral Researcher – Epigenetic Modifiers (Van Andel Research Institute)

Postdoctoral Research Fellow – Small Cell Lung Cancer (Fred Hutchinson Cancer Research Center)


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