Volume 4.29 | Jul 30

Pulmonary Cell News 4.29 July 30, 2015
Pulmonary Cell News
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Researchers Create Promising New Model for Lung Injury Repair
Researchers have created a dynamic functional mouse model for lung injury repair, a tool that will help scientists explain the origins of lung disease and provide a system by which new therapies can be identified and tested. [Press release from Children’s Hospital Los Angeles discussing online prepublication in the American Journal of Respiratory Cell and Molecular Biology] Press Release | Abstract
Model the Human Respiratory Epithelium with PneumaCult™-ALI. Click to View Data.
PUBLICATIONS (Ranked by impact factor of the journal)
Regulation of 26S Proteasome Activity in Pulmonary Fibrosis
To investigate proteasome function during myofibroblast differentiation, scientists treated lung fibroblasts with TGF-β and examined proteasome composition and activity. For in vivo analysis, they used mouse models of lung fibrosis and fibrotic human lung tissue. [Am J Respir Crit Care Med] Abstract | Press Release

The TNF Family Molecules LIGHT and Lymphotoxin αβ Induce a Distinct Steroid-Resistant Inflammatory Phenotype in Human Lung Epithelial Cells
The authors investigated the responsiveness of human lung epithelial cells to the TNF family molecules LIGHT and lymphotoxin αβ (LTαβ). Bronchial and alveolar epithelial cell lines, and primary human bronchial epithelial cells, were stimulated with LIGHT and LTαβ, and expression of inflammatory cytokines and chemokines and markers of epithelial-mesenchymal transition and fibrosis/remodeling were measured. [J Immunol] Abstract

Alpha 1-Antitrypsin Mitigates the Inhibition of Airway Epithelial Cell Repair by Neutrophil Elastase
Investigators determined if neutrophil elastase (NE) activity could inhibit epithelial homeostasis and repair and whether any functional effect was reversible by antiprotease alpha 1-antitrypsin treatment. Viability, inflammation, apoptosis and proliferation were all assessed in healthy non-cystic fibrosis (CF) and CF pediatric primary airway epithelial cells during exposure to physiologically relevant NE. [Am J Respir Cell Mol Biol] Abstract

Decreased CXCL12 Is Associated with Impaired Alveolar Epithelial Cell Migration and Poor Lung Healing after Lung Resection
Scientists determined the role of C-X-C motif chemokine 12 (CXCL12) on alveolar epithelial cell migration and lung wound healing. [Surgery] Abstract

Cell-Contact Dependent Inhibition of Monocytes by Airway Epithelial Cells and Reversion by Infection with Respiratory Syncytial Virus
Scientists determined how bronchial epithelial cells affect the activation of monocytes. Under healthy conditions, airway epithelial cells were shown to inhibit reactivity of monocytes. [Immunobiology] Abstract


Activation of the BMP-BMPR Pathway Conferred Resistance to EGFR-TKIs in Lung Squamous Cell Carcinoma Patients with EGFR Mutations
Researchers reported that the resistance of lung squamous cell carcinomas harboring epidermal growth factor receptor (EGFR) mutations to EGFR tyrosine kinase inhibitors (EGFR-TKIs) was due to the activation of BMP-BMPR-Smad1/5-p70S6K. The combined treatment of these tumor cells with EGFR-TKI, together with inhibitors specific to BMPR or downstream mTOR, effectively reversed the resistance to EGFR-TKI. [Proc Natl Acad Sci USA] Abstract

CXCR7 Mediates TGFβ1-Promoted EMT and Tumor-Initiating Features in Lung Cancer
Transforming growth factor-β1 (TGFβ1) upregulated CXC chemokine receptor expression, migration, invasion, epithelial-mesenchymal transition (EMT) and cancer stem cell formation in lung adenocarcinoma. [Oncogene] Abstract

Minocycline Enhances Mitomycin C-Induced Cytotoxicity through Down-Regulating ERK1/2-Mediated Rad51 Expression in Human Non-Small Cell Lung Cancer Cells
Minocycline treatment inhibited cell viability and proliferation of two non-small cell lung cancer cells, A549 and H1975. Treatment with minocycline decreased Rad51 mRNA and protein levels through MKK1/2-ERK1/2 inactivation. [Biochem Pharmacol] Abstract

DDX5 Promotes Proliferation and Tumorigenesis of NSCLC Cells via Activating β-Catenin Signaling Pathway
Scientists examined the expression of DDX5 in clinical non-small cell lung cancer (NSCLC) samples, investigated its role in regulating NSCLC cell proliferation and tumorigenesis, and explored the possible molecular mechanism. [Cancer Sci] Abstract

Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
Platelet Activating Factor Receptor: Gateway for Bacterial Chronic Airway Infection in Chronic Obstructive Pulmonary Disease and Potential Therapeutic Target
The authors evaluate the respective roles of platelet activating factor receptor (PAFr) and phosphorylcholine (ChoP) in the natural history of chronic obstructive pulmonary disease (COPD) and discuss the potential of the airway epithelial PAFr–bacterial ChoP interaction as a selective anti-infective target in COPD therapeutics. [Expert Rev Respir Med] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
Boehringer Ingelheim Enters into an Exclusive License Agreement with Hanmi Pharmaceutical to Develop 3rd Generation EGFR Targeted Therapy in Lung Cancer
Boehringer Ingelheim and Hanmi Pharmaceutical Co. Ltd announced an exclusive license and collaboration agreement for the development and global commercialization rights of HM61713, a novel 3rd generation EGFR targeted therapy for the treatment of EGFR mutation positive lung cancer. [Boehringer Ingelheim GmbH] Press Release

Moerae Initiates Lipopolysaccharide (LPS) Challenge Study of Inhaled MMI-0100 for Pulmonary Disease Following Encouraging Safety and Tolerability Observed in Single Ascending Dose Phase I Study
Moerae Matrix Inc. announced the initiation of its second Phase I clinical trial with MMI-0100, a first-in-class inhibitor of MAPKAP kinase 2 that is being developed for pulmonary disorders characterized by inflammation and fibrosis. [Moerae Matrix Inc. (PR Newswire Association LLC)] Press Release

Discovery Labs Receives $1.0 Million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury
Discovery Laboratories, Inc. announced that it has received the second $1.0M tranche under a previously awarded Phase II Small Business Innovation Research (SBIR) grant valued at up to $3.0 million to support continued development of the company’s aerosolized KL4 surfactant as a potential medical countermeasure to mitigate acute and chronic/late-phase radiation-induced lung injury. [Discovery Laboratories, Inc.] Press Release

From our sponsor: Learn about applications of ALDHbr cells in regenerative medicine. Watch the video.
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European Medicines Agency (European Union)

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Therapeutic Goods Administration (Australia)
NEW The Presence and Future of the RAS Pathway: From Function and Genomics to Inhibition
October 5-7, 2015
Pamplona, Spain

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Harry Eagle Scholar Awards for Postdoctoral Candidates (Albert Einstein College of Medicine of Yeshiva University)

NEW Postdoctoral Fellow – Biotechnology (Qu Biologics Inc.)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Postdoctoral Positions – Cancer Research (Rutgers University)

Postdoctoral Fellow – Cancer Research (National University of Singapore)

Postdoctoral Training Fellow – Lung Cancer and Drug Resistance (Institute of Cancer Research)

PhD Studentships – Pulmonary Biology and Medicine (University of Giessen Lung Center)

Postdoctoral Fellow – Pulmonary Fibrosis (University of Colorado School of Medicine)

Assistant Professor – Neonatal Pulmonary Biology and Vascular Biology (Medical College of Wisconsin)

Senior Scientist – Stem Cells (Cystic Fibrosis Foundation)

Faculty Positions (Cleveland Clinic)

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