RhoB Loss Induces Rac1-Dependent Mesenchymal Cell Invasion in Lung Cells through PP2A Inhibition
Scientists identified the small GTPase RhoB as a key regulator of bronchial cell morphology in a three-dimensional (3D) matrix. RhoB loss, which is frequently observed during lung cancer progression, induced an epithelial-mesenchymal transition characterized by an increased proportion of invasive elongated cells in 3D. [Oncogene] Abstract
Genomic Alterations in Lung Adenocarcinoma
Data clearly suggest that lung adenocarcinoma is associated with distinct genomic alterations compared with other lung cancer subtypes, and highlight the widespread molecular heterogeneity that underlies the disease. In this review, the authors discuss some of the key findings from genomic studies of lung adenocarcinoma. [Lancet Oncol] Abstract
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