Volume 4.22 | Jun 11

Pulmonary Cell News 4.22 June 11, 2015
Pulmonary Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
EGCG Regulates the Cross-Talk between JWA and Topoisomerase IIα in Non-Small-Cell Lung Cancer (NSCLC) Cells
The regulation of JWA and topoisomerase IIα by (-)-epigallocatechin-3-gallate (EGCG), and thereafter the mutual interaction between them was investigated. The authors revealed that EGCG up-regulated JWA while decreased topoisomerase IIα expression in both human NSCLC cells and an NSCLC xenograft mice model. [Sci Rep] Full Article
Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
 
PUBLICATIONS (Ranked by impact factor of the journal)
Silver Nanowire Interactions with Primary Human Alveolar Type-II Epithelial Cell Secretions: Contrasting Bioreactivity with Human Alveolar Type-I and Type-II Epithelial Cells
Scientists investigated the cellular uptake and toxicity of silver nanowires with human type-I epithelial cell-like cells, in the absence or presence of Curosurf® or harvested primary human type-II epithelial cell secretions. [Nanoscale] Abstract

Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells & Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model
Researchers hypothesized that epidermal growth factor removal or tyrphostin AG1478 treatment of differentiating air-liquid interface cultures from asthmatic children would result in a reduction of epithelial goblet cells and mucus secretion. [PLoS One] Full Article

Particulate Matter (PM10) Induces Metalloprotease Activity and Invasion in Airway Epithelial Cells
Researchers aimed to identify alterations in airway epithelial cells induced by airborne particulate matter with an aerodynamic diameter ≤10 μm (PM10) that could explain how subtoxic exposure promotes a more aggressive in vitro phenotype. [Toxicol Lett] Abstract

Regulation of Epithelial Sodium Channel Expression by Oestradiol and Progestogen in Alveolar Epithelial Cells
In vitro, oestrogen (E) or progestogen (P) alone inhibited 11β-hydroxysteroid dehydrogenase type 2 activity in a dose-dependent manner and increased α-epithelial Na+ channel (ENaC) expression by at least 50%, and E combined with P increased α-ENaC expression by more than 80%. [Respir Physiol Neurobiol] Abstract

LUNG CANCER

Inhibition of IGF1R Signaling Abrogates Resistance to Afatinib (BIBW2992) in EGFR T790M Mutant Lung Cancer Cells
Investigators found that activation of the insulin-like growth factor 1 receptor (IGF1R) signaling pathway contributes to afatinib resistance in non-small cell lung cancer cells harboring the T790M mutation. IGF1R knockdown not only significantly sensitizes resistant cells to afatinib, but also induces apoptosis in afatinib resistance cells. [Mol Carcinog] Abstract

Activation of Endoplasmic Reticulum Stress Is Involved in the Activity of Icariin against Human Lung Adenocarcinoma Cells
Scientists investigated the anticancer activity of icariin against human lung adenocarcinoma cells in vitro and in vivo and explored the role of endoplasmic reticulum stress signaling in this process. [Apoptosis] Abstract

MicroRNA-29b Attenuates Non-Small Cell Lung Cancer Metastasis by Targeting Matrix Metalloproteinase 2 and PTEN
Researchers found that miRNA-29b is differentially expressed in primary cultured CD133-positive A549 cells compared with CD133-negative A549 cells. [J Exp Clin Cancer Res] Abstract | Full Article

Effects of Slit3 Silencing on the Invasive Ability of Lung Carcinoma A549 Cells
High Slit3 expression at the mRNA level, yet not at the protein level, was detected in lung adenocarcinoma A549 cells. The function of Slit3 in tumor migration and invasion was examined by silencing of Slit3 expression in A549 cells. [Oncol Rep] Abstract

Going to ISSCR 2015? We’ll see you there!
 
REVIEWS
Stem Cells for the Prevention of Neonatal Lung Disease
Compelling preclinical data using stem cells to prevent/repair lung damage in animal models of experimental bronchopulmonary dysplasia has built the basis for its translation into the clinic in preterm infants. This review highlights the exciting translation from bench to bedside that will hopefully lead in the near future to improved pulmonary outcomes in preterm infants. [Neonatology] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
SCIENCE NEWS
Saladax Biomedical, Inc. Announces Presentation of CEPAC-TDM Study of Paclitaxel in Non-Small Cell Lung Cancer
Saladax Biomedical, Inc. recently presented results from the largest, randomized, prospective dose adjustment-therapeutic drug monitoring trial ever conducted in oncology: evaluating 304 patients over six years. [Press release from Saladax Biomedical, Inc. (Business Wire) discussing research presented at the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago] Press Release

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INDUSTRY NEWS
BerGenBio Initiates NSCLC Clinical Trial with BGB324 in Combination with Erlotinib
BerGenBio AS announced that its multi-centre open label Phase Ib trial of BGB324, a selective inhibitor of Axl, in patients with Stage IIIb and Stage IV non-small cell lung cancer (NSCLC) in erlotinib-sensitive and refractory patients who have an activating EGFR mutation, is now underway. [BerGenBio AS] Press Release

Definitive Agreement to Acquire CD40LGVAX Vaccine
Cellular Biomedicine Group Inc. announced that it has entered into a definitive agreement to acquire from Blackbird Bio Finance University of South Florida’s next generation GVAX vaccine’s related technologies and know-how. [Cellular Biomedicine Group Inc.] Press Release

STEMCELL Technologies Named Company of the Year by BIOTECanada
STEMCELL Technologies Inc. will be presented with the Biotech Company of the Year award by BIOTECanada at this year’s BIO International Convention in Philadelphia. [BIOTECanada] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 2015 Midwest Conference on Cell Therapy & Regenerative Medicine
September 18-19, 2015
Kansas City, United States

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Researcher – Animal Models of Lung Inflammation (Louisiana State University)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Research Scientist – Respiratory Medicine (University of British Columbia)

Research Scientist I/II – Fibrosis/Oncology/Inflammation Biology (Gilead Sciences)

Postdoctoral Research Fellow – Lung Tumor Microenvironment (Fred Hutchinson Cancer Research Center)

Medical Professional – Molecular Genetic Pathology (Paris Est Créteil)

Postdoctoral Research Fellow – Lung Transplant Immunology (Washington University)

Research Group Leader – Epigenetics and Chronic Obstructive Pulmonary Disease (BioMed X Innovation Center)

Senior PostDoc/Research Group Leader – Chronic Lung Disease (Ludwig Boltzmann Institute for Lung Vascular Research)

Postdoctoral Researcher – Systems Biology (Van Andel Research Institute)

Postdoctoral Research Position – Lung Cancer (University of California, San Francisco)

Postdoctoral Researcher – Pulmonary Developmental Pathology (Drexel University College of Medicine)


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