Volume 4.19 | May 21

Pulmonary Cell News 4.19 May 21, 2015
Pulmonary Cell News
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TOP STORY
Molecule Designed to Treat Lung Cancer Shows Promising Results in Mice
Researchers have identified a new therapy for lung cancer. The therapy has been in development for six years and involves a first-in-class molecule designed by the team. The molecule, RK-33, interrupts the cell cycle of lung cancer cells without harming normal cells, and it is effective both on its own and in combination with radiation therapy. [Press release from Johns Hopkins Medicine discussing online prepublication in EMBO Molecular Medicine] Press Release | Full Article
Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
 
PUBLICATIONS (Ranked by impact factor of the journal)
Continuous Mucociliary Transport by Primary Human Airway Epithelial Cells In Vitro
Scientists characterized a novel method that allows human airway epithelial cells to differentiate into a mucociliary epithelium that transports mucus in a continuous circular track. [Am J Physiol Lung Cell Mol Physiol] Abstract

14,15-Epoxyeicosatrienoic Acid Suppresses Cigarette Smoke Extract-Induced Apoptosis in Lung Epithelial Cells by Inhibiting Endoplasmic Reticulum Stress
Investigators explored the effects of CYP2J2-epoxyeicosatrienoic acids on cigarette smoke extracts-induced apoptosis in human bronchial epithelial cell line and the possible mechanisms involved. [Cell Physiol Biochem] Full Article

Induction and Repair of DNA Cross-Links Induced by Sulfur Mustard in the A-549 Cell Line Followed by a Comet Assay
Using the A-549 lung cell line, the comet assay protocol was optimized for indirect detection of DNA cross-links induced by sulfur mustard. The method is based on the additional treatment of the assayed cells containing cross-links with the chemical mutagen, styrene oxide. [Chem Biol Interact] Abstract

SIRT5 Prevents Cigarette Smoke Extract-Induced Apoptosis in Lung Epithelial Cells via Deacetylation of FOXO3
Researchers showed that cigarette smoke extract (CSE) induces SIRT5 to deacetylate forkhead box O3 (FOXO3) at K271 and K290. Deacetylation of FOXO3 promotes its nuclear localization. Notably, transfection with FOXO3 K271R- or K290R-attenuated CSE-induced apoptosis in SIRT5 knocked down cells, suggesting the protective effects of SIRT5, is mediated by FOXO3. [Cell Stress Chaperones] Abstract

In Vitro Effects Induced by Diesel Exhaust at an Air-Liquid Interface in a Human Lung Alveolar Carcinoma Cell Line A549
Researchers examined the effects induced in vitro in human adenocarcinoma-derived alveolar basal epithelial A549 cells by diesel particulate matter administered into the culture medium or by diesel exhaust administered at an air-liquid interface. [Exp Toxicol Pathol] Abstract

LUNG CANCER

MALT1 Is Required for EGFR-Induced NF-κB Activation and Contributes to EGFR-Driven Lung Cancer Progression
The authors found that mucosa-associated lymphoid tissue 1 (MALT1) is involved in epidermal growth factor receptor (EGFR)-induced nuclear factor kappa B (NF-κB) activation in cancer cells, and that MALT1 deficiency impaired EGFR-induced NF-κB activation. MALT1 mainly functions as a scaffold protein by recruiting E3 ligase TRAF6 to IKK complex to activate NF-κB in response to EGF stimulation. [Oncogene] Abstract

The New InsP3Kinase Inhibitor BIP-4 Is Competitive to InsP3 and Blocks Proliferation and Adhesion of Lung Cancer Cells
Determination of cellular uptake in lung cancer cells revealed that 6% of extracellular BIP-4 is internalized by non-endosomal uptake, showing that BIP-4 is not trapped inside endo/lysosomes but is available to inhibit cellular InsP3Kinase activity. [Biochem Pharmacol] Abstract

The Long Noncoding RNA MEG3 Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma
Scientists observed the expression of maternally expressed gene 3 (MEG3) in lung adenocarcinoma (LAD) and evaluated its biological role and clinical significance in the resistance of LAD cells to cisplatin. [PLoS One] Full Article

MicroRNA miR-10b Inhibition Reduces Cell Proliferation and Promotes Apoptosis in Non-Small Cell Lung Cancer (NSCLC) Cells
To study the potential function of miR-10b involved in the regulation of lung tumors, researchers monitored NSCLC cell behavior including proliferation, apoptosis and cell cycle using CCK-8 and flow cytometry analysis. [Mol Biosyst] Abstract

miR-183 Promotes Growth of Non-Small Cell Lung Cancer Cells through FoxO1 Inhibition
The authors analyzed the effects of microRNA (miR)-183 on non-small cell lung cancer cell growth in vitro using a microculture tetrazolium assay and in vivo by visualizing tumor growth using bioluminescence assay. [Tumor Biol] Abstract

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REVIEWS
Periostin: Its Role in Asthma and Its Potential as a Diagnostic or Therapeutic Target
The authors focus on what is known about periostin and its role in the pathophysiological mechanisms that mediate asthma in order to evaluate the potential for periostin to serve as a biomarker and therapeutic target for the detection and treatment of asthma, respectively. [Respir Res] Full Article

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
SCIENCE NEWS
Genentech’s Investigational Immunotherapy MPDL3280A Doubled the Likelihood of Survival Compared with Chemotherapy in People with a Specific Type of Lung Cancer
Genentech announced interim results from a global, randomized Phase II study in people with previously treated non-small cell lung cancer (NSCLC). The study showed the investigational cancer immunotherapy MPDL3280A doubled the likelihood of survival in people whose cancer expressed the highest levels of PD-L1 (programmed death ligand-1) compared with docetaxel chemotherapy. [Press release from Genentech, Inc. discussing research to be presented at the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago] Press Release

Genentech’s Investigational Medicine Alectinib Shrank Tumors in Nearly Half of People with Specific Type of Lung Cancer
Genentech announced positive results from two pivotal studies that showed alectinib, its oral investigational anaplastic lymphoma kinase (ALK) inhibitor, shrank tumors in people with advanced ALK-positive non-small cell lung cancer whose disease had progressed following treatment with crizotinib. [Press release from Genentech, Inc. discussing research to be presented at the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago] Press Release

New Troops in the Fight against Cancer
Pembrolizumab has shown anti-tumor activity in numerous advanced malignancies, including melanoma and non-small cell lung cancer. This clinical trial in particular focused on the activity of pembrolizumab in tumors with high PD-L1 expression, which may predict response to pembrolizumab. [Press release from Rutgers Cancer Institute of New Jersey discussing research to be presented at the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago] Press Release

New Data Analyses on Investigational Tiotropium/Olodaterol Respimat® Showed Greater Lung Function Improvement Compared to Tiotropium and Olodaterol Alone
Boehringer Ingelheim Pharmaceuticals, Inc. announced new data analyses from the pivotal Phase III TONADO™ 1&2 studies, which explored the efficacy and safety of investigational tiotropium/olodaterol delivered via the Respimat® inhaler for chronic obstructive pulmonary disease compared to the individual components alone. [Press release from Boehringer Ingelheim Pharmaceuticals, Inc. discussing research presented at the American Thoracic Society (ATS) 2015 International Conference, Denver] Press Release

ProMetic Provides Update on PBI-4050 for the Treatment of Idiopathic Pulmonary Fibrosis (IPF)
ProMetic Life Sciences Inc. presented new pre-clinical data on PBI-4050, its orally active anti-fibrotic drug candidate in Phase II clinical trials for the treatment of IPF. [Press release from ProMetic Life Sciences Inc. discussing research presented at the American Thoracic Society (ATS) 2015 International Conference, Denver] Press Release

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INDUSTRY NEWS
New Studies Strengthen Argument Against e-Cigarettes
At ATS 2015 four studies were presented that provide further scientific evidence that electronic cigarettes (e-cigarettes) are harmful to users’ health and are not an effective long-term smoking cessation tool. [American Thoracic Society (ATS)] Press Release

Cancer Prevention and Research Institute of Texas Awards 41 New Grants
The Cancer Prevention and Research Institute of Texas awarded 28 grants through its academic research program, 11 grants through its prevention program and two grants through its product development research program. [Cancer Prevention and Research Institute of Texas] Press Release

Dr. Erica Herzog Awarded Jo Rae Wright Award for Outstanding Science
Dr. Erica L. Herzog, associate professor of medicine (pulmonary) at the Yale School of Medicine, has won the Jo Rae Wright Award for Outstanding Science, given by the American Thoracic Society. [Yale University] Press Release
 
POLICY NEWS
FTC, All 50 States and D.C. Charge Four Cancer Charities with Bilking Over $187 Million from Consumers
The Federal Trade Commission and 58 law enforcement partners from every state and the District of Columbia have charged four sham cancer charities and their operators with bilking more than $187 million from consumers. [Federal Trade Commission] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 4th Annual Excellence in Lung Cancer Screening & Continuum of Care
September 30-October 2, 2015
Cleveland, United States

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Fellow – Lung Tumor Microenvironment (Fred Hutchinson Cancer Research Center)

NEW Medical Professional – Molecular Genetic Pathology (Paris Est Créteil)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Postdoctoral Research Fellow – Lung Transplant Immunology (Washington University)

Research Group Leader – Epigenetics and Chronic Obstructive Pulmonary Disease (BioMed X Innovation Center)

Senior PostDoc/Research Group Leader – Chronic Lung Disease (Ludwig Boltzmann Institute for Lung Vascular Research)

Postdoctoral Position – Immunology and Virology (Herman B Wells Center for Pediatric Research)

Postdoctoral Researcher – Systems Biology (Van Andel Research Institute)

Postdoctoral Research Position – Lung Cancer (University of California, San Francisco)

Postdoctoral Researcher – Pulmonary Developmental Pathology (Drexel University College of Medicine)


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