Epigenetic Regulation of Tolerance to TLR Ligands in Alveolar Epithelial Cells
The authors hypothesized that type II alveolar epithelial cells (AECs) develop a tolerance phenotype upon repeated Toll-like receptor (TLR) agonist exposure. Sequential treatment of primary AECs or MLE-12 with TLR agonists resulted in induction of either tolerance or cross-tolerance. [Am J Respir Cell Mol Biol] Abstract
Circadian Clock Coupled Lung Cellular and Molecular Functions in Chronic Airway Diseases
The authors review current understanding of clock-controlled cellular and molecular functions in the lungs, the impact of clock dysfunction in chronic airway disease and the response of the pulmonary clock to different environmental perturbations. Further, they discuss the evidence for candidate signaling pathways, such as the sirtuin 1-BMAL1-REV-ERBα axis as novel target for chronopharmacological management of chronic airway diseases. [Am J Respir Cell Mol Biol] Abstract
Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
SCIENCE NEWS
Pivotal Data for Roche Medicines in Lung and Blood Cancers to Be Presented
Roche announced that data from ten of its approved cancer medicines and ten of its investigational medicines will be presented. These data demonstrate the strength of Roche’s oncology pipeline, particularly in cancer immunotherapy and personalized medicine. [Press release from Roche Ltd. discussing research to be presented at the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago]
Press Release
Lilly and BioNTech Announce Research Collaboration on Novel Cancer Immunotherapies
Eli Lilly and Company and BioNTech AG announced they have entered into a research collaboration to discover novel cancer immunotherapies. The companies will seek to use the power of the body’s own immune system to attack cancer cells and create possible new treatment options for cancer patients. [Eli Lilly] Press Release
Recruit Top Talent:
Reach more than 60,000 potential candidates by posting
your organization’s career opportunities on the Connexon Creative Job Board at no cost.
Have we missed an important article or publication in Pulmonary Cell News? Click here to submit!