Volume 4.16 | Apr 30

Pulmonary Cell News 4.16 April 30, 2015
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Nanoparticles that Deliver Triplex-Forming Peptide Nucleic Acid Molecules Correct F508del CFTR in Airway Epithelium
The authors used triplex-forming peptide nucleic acids and donor DNA in biodegradable polymer nanoparticles to correct F508del. They confirmed modification with sequencing and a functional chloride efflux assay. In vitro correction of chloride efflux occurs in up to 25% of human cells. [Nat Commun] Abstract
Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
 
PUBLICATIONS (Ranked by impact factor of the journal)
CARM1 Regulates Alveolar Epithelial Senescence and Elastase-Induced Emphysema Susceptibility
Researchers investigated the contribution of coactivator-associated arginine methyltransferase-1 (CARM1) to alveolar rarefication using the mouse model of elastase-induced emphysema in vivo and siRNA-mediated knockdown in alveolar epithelial type-II-like LA4 cells in vitro. [Am J Respir Cell Mol Biol] Abstract

Deleterious Impact of Hyperglycemia on Cystic Fibrosis Airway Ion Transport and Epithelial Repair
Scientists evaluated the impact of hyperglycemia on airway epithelial repair and transepithelial ion transport, which are critical in maintaining lung integrity and function. Non-cystic fibrosis (CF) and CF airway epithelial cells were exposed to low or high glucose before ion current and wound repair rate measurements. [J Cyst Fibros] Abstract

Glucocorticoids Distinctively Modulate the CFTR Channel with Possible Implications in Lung Development and Transition into Extrauterine Life
Researchers analyzed the influence of glucocorticoids on pulmonary Cl channels. Alveolar cells from fetal and adult rats, A549 cells, bronchial Calu-3 and 16HBE14o- cells, and primary rat airway cells were studied with real-time quantitative PCR and Ussing chambers. [PLoS One] Full Article

Effect of Elevated Carbon Dioxide on Bronchial Epithelial Innate Immune Receptor Response to Organic Dust from Swine Confinement Barns
Innate immune responses to Pam3CSK4, LPS and a complex innate immune stimulus, an extract from the organic dust of swine confinement barns, were tested in a human bronchial epithelial cell line, BEAS-2B. [Int Immunopharmacol] Abstract

LUNG CANCER

FLLL12 Induces Apoptosis in Lung Cancer Cells through a p53/p73-Independent but Death Receptor 5-Dependent Pathway
Scientists investigated the mechanism of anti-tumor effect of FLLL12 in lung cancers. IC50 values measured by sulforhodamine B assay at 72 hours and apoptosis assays suggest that FLLL12 is 5-10–fold more potent than curcumin against a panel of premalignant and malignant lung cancer cell lines, depending on the cell line. [Cancer Lett] Abstract

PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells
Scientists found that PNAS-4 expression in lung tumor tissues is significantly lower than that in adjacent lung tissues and its expression is significantly increased in A549 cells after exposure to cisplatin, methyl methane sulfonate and mitomycin, and that its overexpression induces S-phase arrest and apoptosis in lung cancer cells, leading to proliferation inhibition irrespective of their p53 status. [J Biol Chem] Abstract | Full Article

miR-205 and miR-218 Expression Is Associated with Carboplatin Chemoresistance and Regulation of Apoptosis via Mcl-1 and Survivin in Lung Cancer Cells
The authors investigated the role of two distinct miR members, the miR-205 and the tumor suppressor miR-218 in the proliferation, invasion and induction of apoptosis in lung cancer cells after carboplatin treatment. [Cell Signal] Abstract

High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts
Researchers established co-cultures of invasive or non-invasive NSCLC cell lines and various types of fibroblasts to more precisely characterize the molecular mechanism of tumor-stroma crosstalk in lung cancer. [PLoS One] Full Article

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REVIEWS
Implication of Interleukin (IL)-18 in the Pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)
Published data prompt the hypothesis that IL-18 induces a broad spectrum of COPD-like inflammatory and remodeling responses in the murine lung and also induces mixed type 1, type 2, and type 17 cytokine responses. The majority of studies identify IL-18 as a potential target for future COPD therapeutics to limit both the destructive and remodeling processes occurring in COPD lungs. [Cytokine] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

Target Cancer Metabolism
 
INDUSTRY NEWS
Cancer Treatment Centers of America at Western Regional Medical Center Launches Phase II of Innovative ‘PembroPlus’ Clinical Trial
Cancer Treatment Centers of America® at Western Regional Medical Center has begun the Phase II portion of the first of six arms of this first-of-its-kind clinical trial, using a new immunotherapy treatment for patients with advanced small cell lung cancer, pancreatic cancer and connective-tissue cancers, including breast cancer. [Cancer Treatment Centers of America, Inc.] Press Release

OncoGenex Announces Custirsen Phase III “ENSPIRIT” Trial Update
OncoGenex Pharmaceuticals, Inc. announced it has filed an amendment with the U.S. Food and Drug Administration, as well as initiated filing with regulatory agencies in other countries, to amend the statistical design and analysis plan of its pivotal, international Phase III ENSPIRIT trial evaluating custirsen in the treatment of non-small cell lung cancer (NSCLC). [OncoGenex Pharmaceuticals, Inc.] Press Release

UAB Secures $11 Million DOD Grant for COPD Study
Researchers at the University of Alabama at Birmingham (UAB) will lead a multisite study of the role of beta blockers in patients with chronic obstructive pulmonary disease, or COPD. The study is funded by an $11 million grant from the United States Department of Defense (DOD). [University of Alabama at Birmingham] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Cells: From Robert Hooke to Cell Therapy – A 350 Year Journey
October 5-6, 2015
London, United Kingdom

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Research Specialist – Lung and Vascular Biology (University of Illinois Chicago College of Medicine)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Postdoctoral Research Position – Lung Cancer (University of California, San Francicso)

PhD Student – Molecular Biology and Medicine of the Lung (Philipps-Universität Marburg)

Professorship – Lung Epithelial Cell Plasticity (Ludwig-Maximilians-Universitat München)

PhD Position – Development of a 3D In Vitro Model of Infected Airway (Helmholtz Centre for Infection Research)

PhD Studentship – Cystic Fibrosis (University of East Anglia)

Postdoctoral Researcher – Pulmonary Developmental Pathology (Drexel University College of Medicine)

Postdoctoral Position – Airway Disease and Inflammation (Brigham and Women’s Hospital Harvard Medical School)

Postdoctoral Scholar – Molecular Mechanisms of Lung Cancer, Lung Regeneration and Lung Development (University of California, San Francisco)


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