Volume 4.14 | Apr 16

Pulmonary Cell News 4.14 April 16, 2015
Pulmonary Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Limber Lungs: One Type of Airway Cell Can Regenerate Another Lung Cell Type
Researchers describe a way that lung tissue can regenerate after injury. They found that lung tissue has more dexterity in repairing tissue than once thought. [Press release from the University of Pennsylvania discussing online publication in Nature Communications] Press Release | Abstract
Model the Human Respiratory Epithelium with PneumaCult™-ALI. Click to View Data
 
PUBLICATIONS (Ranked by impact factor of the journal)
Th2-Cytokines Impair Innate Immune Responses to Rhinovirus in Respiratory Epithelial Cells
The authors measured the effects of Th2 cytokines on bronchial epithelial cell innate immune antiviral responses by assessing interferon induction following rhinovirus-16 infection. [Allergy] Abstract

Human Normal Bronchial Epithelial Cells: A Novel In Vitro Cell Model for Toxicity Evaluation
Scientists established human normal bronchial epithelial cells using a defined primary epithelial cell culture medium without transduction of exogenous genes. [PLoS One] Full Article

MAPK Pathway Mediates Epithelial-Mesenchymal Transition Induced by Paraquat in Alveolar Epithelial Cells
Investigators showed that paraquat-induced epithelial RLE-6NT cells developed mesenchymal cell characteristics, as indicated by a significant decrease in the epithelial marker E-cadherin and a significant increase in the extracellular matrix marker α-smooth muscle actin in a dose and time-dependent manner. [Environ Toxicol] Abstract

Evaluation of Gene Expression Changes in Human Primary Lung Epithelial Cells Following 24-Hr Exposures to Inorganic Arsenic and Its Methylated Metabolites and to Arsenic Trioxide
The concentration response for altered gene expression in primary lung epithelial cells was determined following two treatments with arsenicals: a mixture of trivalent arsenic compounds representative of urinary arsenic concentrations in exposed human populations, and arsenite a common form of inhaled arsenic dust that is frequently used in both in vivo and in vitro experimental exposures. [Environ Mol Mutagen] Abstract

HMGB1 Binding to Receptor for Advanced Glycation End Products Enhances Inflammatory Responses of Human Bronchial Epithelial Cells by Activating p38 MAPK and ERK1/2
Researchers investigated receptor expression and proinflammatory cytokine production by primary cultures of human bronchial epithelial cells stimulated by high mobility group box protein 1 (HMGB1). [Mol Cell Biochem] Abstract

LUNG CANCER

Collateral Chemoresistance to Anti-Microtubule Agents in a Lung Cancer Cell Line with Acquired Resistance to Erlotinib
Scientists investigated the sensitivity of erlotinib-resistant tumor cells to five cytotoxic agents using an in vitro epidermal growth factor receptor-tyrosine kinase inhibitor-resistant model. Four erlotinib-sensitive lung adenocarcinoma cell lines and their resistant derivatives were tested. [PLoS One] Full Article

Fructus phyllanthi Tannin Fraction Induces Apoptosis and Inhibits Migration and Invasion of Human Lung Squamous Carcinoma Cells In Vitro via MAPK/MMP Pathways
The authors investigated the anticancer mechanisms of F. phyllanthi tannin fraction in human lung squamous carcinoma cells in vitro. [Acta Pharmacol Sin] Abstract

EGFR-Independent Autophagy Induction with Gefitinib and Enhancement of Its Cytotoxic Effect by Targeting Autophagy with Clarithromycin in Non-Small Cell Lung Cancer Cells
Gefitinib, an inhibitor for EGFR tyrosine kinase, potently induced autophagy in non-small cell lung cancer cell lines such as PC-9 cells expressing constitutively activated EGFR kinase by EGFR gene mutation as well as A549 and H226 cells with wild-type EGFR. [Biochem Biophys Res Commun] Abstract

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REVIEWS
Bronchial Epithelial Cells: The Key Effector Cells in the Pathogenesis of Chronic Obstructive Pulmonary Disease?
The authors discuss the abnormal function of bronchial epithelial cells within a disturbed immune homeostatic environment consisting of ongoing inflammation, oxidative stress and small airway obstruction. They provide an overview of recent insights into the function of the bronchial epithelium in the pathogenesis of chronic obstructive pulmonary disease and how this may provide novel therapeutic approaches for a number of chronic lung diseases. [Respirology] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

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SCIENCE NEWS
Biothera Immunotherapy Combination Results in Tumor Reduction During Maintenance Phase of Non-Small Cell Lung Cancer Study
The combination of the investigational cancer immunotherapy Imprime PGG and the monoclonal antibody bevacizumab achieved additional meaningful reductions in tumor burden during the maintenance phase of Biothera’s recent Phase II clinical trial in non-small cell lung cancer. [Press release from Biothera discussing research presented at the European Lung Cancer Conference (ELCC), Geneva] Press Release

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INDUSTRY NEWS
Puma Biotechnology Expands Cohort in Phase II Trial of PB272 in HER2 Mutation Positive Cancer Patients
Puma Biotechnology, Inc. has expanded the second cohort from its Phase II clinical trial of its lead drug candidate PB272 as a single agent in patients with solid tumors who have an activating HER2 mutation. The cohort that has been expanded is the cohort that includes patients with metastatic non-small cell lung cancer and whose tumors have a HER2 mutation. [Puma Biotechnology, Inc.] Press Release

DiscoveryBioMed, Inc. Is Developing a Novel “Dual Action” Small Molecule Monotherapy for All Cystic Fibrosis (CF) Patients
DiscoveryBioMed, Inc. has discovered and is developing a novel class of small molecule monotherapy that affects both major drug targets that are abnormal and underlie the pathophysiological features of CF. Proper function of the two target proteins that serve as transporters for salt and water into the airways is critical for hydration of the lung and airways and clearance of mucus and harmful inhaled materials. [DiscoveryBioMed, Inc. (Business Wire)] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW ISSCR 2015 Annual Meeting
June 24-27, 2015
Stockholm, Sweden

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW PhD Student – Molecular Biology and Medicine of the Lung (Philipps-Universität Marburg)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Professorship – Lung Epithelial Cell Plasticity (Ludwig-Maximilians-Universitat München)

PhD Position – Development of a 3D In Vitro Model of Infected Airway (Helmholtz Centre for Infection Research)

Research Assistant – Inflammation in the Lung during Viral Infection (Duke-NUS Graduate Medical School Singapore)

PhD Studentship – Cystic Fibrosis (University of East Anglia)

Postdoctoral Fellowship – Pulmonary Genetic Medicine (Cornell University)

Postdoctoral Researcher – Pulmonary Developmental Pathology (Drexel University College of Medicine)

Postdoctoral Position – Airway Disease and Inflammation (Brigham and Women’s Hospital Harvard Medical School)

Postdoctoral Scholar – Molecular Mechanisms of Lung Cancer, Lung Regeneration and Lung Development (University of California, San Francisco)


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