Volume 4.08 | Mar 5

Pulmonary Cell News 4.08 March 5, 2015
Pulmonary Cell News
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Restoring Ability to Halt Cell Division May Protect Lung Cells from Cancer
Researchers have identified a novel role for a signaling mechanism in lung cells that permanently places them into a state of suspended animation called senescence. Alive but unable to do much of anything, including divide, senescent cells cannot become cancerous. [Press release from University of Illinois at Chicago discussing online prepublication in Oncogene] Press Release | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Effect of Nonendocytic Uptake of Nanoparticles on Human Bronchial Epithelial Cells
Researchers applied a unique delivery method, nanochannel electroporation (NEP), to produce predominantly nonendocytic uptakes of quantum dots and multiwalled carbon nanotubes with different chemical modifications. NEP delivery bypassed endocytosis by electrophoretic injection of nanoparticles into human bronchial epithelial cells at different dosages. [Anal Chem] Abstract | Graphical Abstract

Silencing Angiopoietin-Like Protein 4 (ANGPTL4) Protects against Lipopolysaccharide-Induced Acute Lung Injury via Regulating SIRT1 /NF-kB Pathway
Scientists reported that angptl4 levels were increased both in human alveolar epithelial A549 cells and lung tissues obtained from a mouse model of lipopolysaccharide (LPS)-induced acute lung injury. Angptl4 expression was induced by LPS in alveolar epithelial cells, whereas LPS-induced lung inflammation, lung permeability, tissue damage and mortality rates were attenuated in AngsiRNA-treated mice. [J Cell Physiol] Abstract

Phenotypic Responses of Differentiated Asthmatic Human Airway Epithelial Cultures to Rhinovirus
Scientists evaluated an in vitro air liquid interface cultured human airway epithelial cell model for human rhinovirus (HRV) infection, and identified gene expression patterns associated with asthma intrinsically and/or after HRV infection using this model. [PLoS One] Full Article

The Effect of Fe2O3 and ZnO Nanoparticles on Cytotoxicity and Glucose Metabolism in Lung Epithelial Cells
Researchers demonstrate that ZnO nanoparticles, but not Fe2O3 nanoparticles, induce cell cycle arrest, cell apoptosis, reactive oxygen species production, mitochondrial dysfunction and glucose metabolism perturbation, which are responsible for cytotoxicity. [J Appl Toxicol] Abstract

RNA-Binding Motif Protein 5 Negatively Regulates the Activity of Wnt/β-Catenin Signaling in Cigarette Smoke-Induced Alveolar Epithelial Injury
Scientists determined the involvement of RNA-binding motif protein 5 and Wnt/β-catenin signaling in cigarette smoke-induced alveolar epithelial injury, as well as the interaction between both. They revealed that cigarette smoke extract inhibited A549 cell viability in both a dose- and time-dependent manner. [Oncol Rep] Abstract


Protease-Mediated Release of Chemotherapeutics from Mesoporous Silica Nanoparticles to Ex Vivo Human and Mouse Lung Tumors
Scientists provide proof-of-concept evidence for successful matrix metalloproteinase 9-triggered drug release from mesoporous silica nanoparticles in human tumor cells and in mouse and human lung tumors using the novel technology of ex vivo 3D lung tissue cultures. [ACS Nano]
Abstract | Graphical Abstract | Press Release

Assessment of ABT-263 Activity across a Cancer Cell Line Collection Leads to a Potent Combination Therapy for Small-Cell Lung Cancer
Researchers examined the efficacy of ABT-263 across >500 cancer cell lines, including 311 for which they had matched expression data for select genes. They found that high expression of the proapoptotic gene Bcl2-interacting mediator of cell death predicts sensitivity to ABT-263. [Proc Natl Acad Sci USA] Abstract

PARVA Promotes Metastasis by Modulating ILK Signaling Pathway in Lung Adenocarcinoma
Using a lung cancer invasion cell line model and expression microarrays, researchers identified α-parvin (PARVA) as a potential oncogene. The overexpression of PARVA increased cell invasion, colony-forming ability and endothelial cell tube formation. By contrast, knockdown of PARVA inhibited invasion and tube formation in vitro. [PLoS One] Full Article

C6orf106 Enhances NSCLC Cell Invasion by Upregulating Vimentin, and Downregulating E-Cadherin and P120ctn
The relationships between subcellular localization and clinical pathological factors were analyzed. Through chromosome 6 open reading frame 106 (C6orf106) overexpression and repression, respectively, in lung cancer cell lines, investigators explored the effect of this molecule on non-small cell lung cancer (NSCLC) invasion abilities. [Tumor Biol] Abstract

Pemetrexed Induces Apoptosis in Malignant Mesothelioma and Lung Cancer Cells through Activation of Reactive Oxygen Species and Inhibition of Sirtuin 1
Scientists investigated the involvement of reactive oxygen species and sirtuin 1 in pemetrexed-induced apoptosis in MSTO-211 malignant mesothelioma cells and A549 non-small cell lung cancer cells. [Oncol Rep] Abstract

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Role of Infection in Exacerbations of Chronic Obstructive Pulmonary Disease
The authors present the latest findings on the cause, pathogenesis and management of patients with chronic obstructive pulmonary disease and an infective phenotype. [Curr Opin Pulm Med] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

4th Annual Cell Line Development & Engineering Asia
Dr. Julie Brahmer, MD, Named March LUNGevity Hero for Research in Groundbreaking Field of Immunotherapy
To kick off Women in History month, LUNGevity Foundation announced Dr. Julie Brahmer, MD, as the March LUNGevity Hero for her work in the field of immunotherapy for lung cancer patients. [LUNGevity Foundation (PR Newswire Association LLC)] Press Release | Blog Post

FDA Approves Opdivo (Nivolumab) for the Treatment of Patients with Previously Treated Metastatic Squamous Non-Small Cell Lung Cancer
Bristol-Myers Squibb Company announced that the U.S. Food and Drug Administration (FDA) has approved Opdivo injection, for intravenous use, for the treatment of patients with metastatic squamous non-small cell lung cancer with progression on or after platinum-based chemotherapy. [Bristol-Myers Squibb Company]
Press Release

ABRAXANE® Approved by European Commission for First-Line Treatment of Patients with Non-Small Cell Lung Cancer
Celgene International Sàrl announced that the European Commission has approved ABRAXANE® in combination with carboplatin for the first-line treatment of non-small cell lung cancer in adult patients who are not candidates for potentially curative surgery and/or radiation therapy. [Celgene International Sàrl]
Press Release

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NEW Stem Cell Summit 2015
April 27-29, 2015
Boston, United States

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW PhD Studentship – Mouse Models of Asthma (University of Queensland)

NEW Postdoctoral Scholar – Molecular Mechanisms of Lung Cancer, Lung Regeneration and Lung Development (University of California, San Francisco)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Fibrotic Lung Disease (University of California, San Diego)

Postdoctoral Position – Tumor Biology (Max Planck Institute for Heart and Lung Research)

Director – Vector Production (Sangamo BioSciences, Inc.)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Postdoctoral Fellow – Lung Cancer Development and Progression (The University of Texas MD Anderson Cancer Center)

Postdoctoral Fellow – Cystic Fibrosis Research (University of Tennessee Health Science Center)

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