Volume 4.06 | Feb 19

Pulmonary Cell News 4.06 February 19, 2015
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Inhibition of Mutant EGFR in Lung Cancer Cells Triggers SOX2-FOXO6 Dependent Survival Pathways
In characterizing early transcriptional changes following drug treatment of mutant EGFR-addicted cells, scientists identified the stem cell transcriptional regulator SOX2 as being rapidly and specifically induced, both in vitro and in vivo. [eLife] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Competitive Fitness of Influenza B Viruses with Neuraminidase Inhibitor-Resistant Substitutions in a Co-Infection Model of the Human Airway Epithelium
Researchers examined the replicative capacity and relative fitness in normal human bronchial epithelial cells of recombinant influenza B/Yamanashi/166/1998 viruses containing a single amino acid substitution in neuraminidase (NA) that is associated with NA inhibitor-resistance. [J Virol] Abstract

Quantitative Proteomics Reveals an Altered Cystic Fibrosis In Vitro Bronchial Epithelial Secretome
Researchers carried out quantitative proteomics of in vitro apical secretions from air-liquid interface cultures of three life-extended cystic fibrosis (CF) and three non-CF human bronchial epithelial cells following labeling of CF cells by stable isotope labeling with amino acids in cell culture. [Am J Respir Cell Mol Biol] Abstract

Hyperoxia Stimulates the Transdifferentiation of Type II Alveolar Epithelial Cells in Newborn Rats
Expressions of type I alveolar epithelial cell (AEC) and type II AEC (AEC II) markers were detected at three levels: in intact lung tissue, in AEC II isolated from rats in the two groups, and in AEC II isolated from newborn rats which were further cultured under either hyperoxic or normoxic conditions. [Am J Physiol Lung Cell Mol Physiol] Abstract

CDK14 Expression Is Down-Regulated by Cigarette Smoke In Vivo and In Vitro
Cigarette smoke-induced down-regulation of CDK14 mRNA and protein levels was observed in several lung epithelium-derived cell lines including primary normal human bronchial epithelial cells. [Toxicol Lett] Abstract

Expression and Function of the Epithelial Sodium Channel δ-Subunit in Human Respiratory Epithelial Cells In Vitro
Using human airway epithelial cell lines as well as human alveolar epithelial type I-like cells in primary culture, scientists studied the contribution of the epithelial sodium channel δ-subunit to transepithelial sodium transport in human lung in vitro. [Pflugers Arch] Abstract

LUNG CANCER

Molecular Changes Associated with Acquired Resistance to Crizotinib in ROS1-Rearranged Non-Small Cell Lung Cancer (NSCLC)
Scientists identified molecular alterations in crizotinib-resistant tumors from two NSCLC patients with the CD74-ROS1 rearrangement, and in HCC78 cells harboring SLC34A2-ROS1 that showed resistance to crizotinib. [Clin Cancer Res] Abstract

β-PIX Controls Intracellular Viscoelasticity to Regulate Lung Cancer Cell Migration
Researchers found that lung adenocarcinoma cells isolated from the secondary lung cancer of the lymph nodes, H1299 cells, show specific dynamics in terms of the actin cytoskeleton and focal adhesions. [J Cell Mol Med] Abstract | Full Article

CD133-Positive Cells from Non-Small Cell Lung Cancer Show Distinct Sensitivity to Cisplatin and Afatinib
Scientists addressed the role of the CD133/EpCAM stem cell-related markers and explore cell sensitivity to cisplatin and to the epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor, afatinib. Three human non-small cell lung cancer (NSCLC) cell lines, one wild-type and two harboring EGFR mutations, as well as 20 NSCLC primary cultures, were grown in non-differentiating culture conditions for stem cell enrichment. [Arch Immunol Ther Exp] Abstract

CCR9-CCL25 Interaction Suppresses Apoptosis of Lung Cancer Cells by Activating the PI3K/Akt Pathway
Researchers selectively depleted CC chemokine receptor-9 (CCR9) and inhibited CCR9-CCL25 interaction in non-small cell lung cancer cells using small recombinant lentivirus-mediated miRNA, and investigated the tumorigenic effects in vitro and in vivo. [Med Oncol] Abstract

Model the Human Respiratory Epithelium with PneumaCult™-ALI. Click to View Data.
 
REVIEWS
Molecular Targeted Therapy in the Treatment of Advanced Stage Non-Small Cell Lung Cancer (NSCLC)
The authors address the current status of clinically relevant driver mutations and emerging new molecular subsets in lung adenocarcinoma and squamous cell carcinoma, and the role of targeted therapy and mechanisms of acquired resistance to targeted therapy. [Respirology] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
INDUSTRY NEWS
Takeda Announces Phase III MONET-A Study Evaluating Motesanib (AMG 706) in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer Does Not Meet Primary Endpoint
Takeda Pharmaceutical Company Limited announced the primary endpoint of progression-free survival was not met in the Phase III MONET-A study of patients with stage IV non-squamous non-small cell lung cancer who were randomized to treatment with investigational motesanib in combination with paclitaxel and carboplatin compared to placebo in combination with paclitaxel and carboplatin. [Takeda Pharmaceutical Company Limited] Press Release

Kaul Foundation Donates $7 Million for UAB Personalized Medicine Institute
The Hugh Kaul Foundation has donated $7 million to the University of Alabama at Birmingham (UAB) to establish the Hugh Kaul Personalized Medicine Institute at UAB. [University of Alabama at Birmingham]
Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 2015 Conference on Advances in Cell Biology (CACB 2015)
March 20-22, 2015
Reston, United States

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Tumor Biology (Max Planck Institute for Heart and Lung Research)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Research Fellow – Allergic Airway Disease and Pulmonary Inflammation (Brigham & Women’s Hospital – Harvard Medical School)

Director – Vector Production (Sangamo BioSciences, Inc.)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

PhD Studentships – Molecular Imaging and Sensing of Lung Inflammation, Infection and Regeneration (University of Edinburgh)

Postdoctoral Fellow – Lung Cancer Development and Progression (The University of Texas MD Anderson Cancer Center)

Postdoctoral Fellow – Cystic Fibrosis Research (University of Tennessee Health Science Center)

Postdoctoral Research Fellow – Post-Transcriptional Gene Regulation Governing Cancer Cell Behavior (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Wnt Signaling in Development and Disease (Van Andel Research Institute)


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