Volume 4.02 | Jan 22

Pulmonary Cell News 4.02 January 22, 2014
Pulmonary Cell News
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Pyruvate Carboxylase Is Critical for Non-Small-Cell Lung Cancer Proliferation
Investigators infused patients with early-stage non-small-cell lung cancer with uniformly 13C-labeled glucose before tissue resection and determined that the cancerous tissues in these patients had enhanced pyruvate carboxylase (PC) activity. PC knockdown induced multinucleation, decreased cell proliferation and colony formation in human non-small-cell lung cancer cells, and reduced tumor growth in a mouse xenograft model. [J Clin Invest] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Increased IL-33 Expression in Chronic Obstructive Pulmonary Disease
Researchers investigated the expression of interleukin-33 (IL-33) in chronic obstructive pulmonary disease (COPD) and to aimed determine whether IL-33 participates in the initiation and progression of COPD. [Am J Physiol Lung Cell Mol Physiol] Abstract

Temporal-Spatial Variations of the Physicochemical Characteristics of Air Pollution Particulate Matter (PM2.5-0.3) and Toxicological Effects in Human Bronchial Epithelial Cells (BEAS-2B)
Researchers studied some physicochemical characteristics and toxicological endpoints of PM2.5-0.3 samples produced during two different seasons in three different surroundings were studied, thereby expecting to differentiate their respective adverse effects in BEAS-2B cells. [Environ Res] Abstract

Role of p53-Fibrinolytic System Cross-Talk in the Regulation of Quartz-Induced Lung Injury
Scientists explored whether p53-mediated changes in the urokinase-type plasminogen activator (uPA) system contributes to silica-induced lung injury. Treatment of wild-type mice with caveolin-1 scaffolding domain peptide inhibits PAI-1, restores uPA expression and prevents alveolar epithelial cell apoptosis by suppressing p53, which is otherwise induced in mice exposed to silica. [Toxicol Appl Pharmacol] Abstract

Conditional Overexpression of TGFβ1 Promotes Pulmonary Inflammation, Apoptosis and Mortality via TGFβR2 in the Developing Mouse Lung
Researchers revealed that increased transforming growth factor beta 1 (TGFβ1) expression in newborn mice lungs leads to increased mortality, macrophage and immature monocyte infiltration, apoptotic cell death specifically in type II alveolar epithelial cells, impaired alveolarization, and dysregulated angiogenic molecular markers. [Respir Res] Abstract | Full Article

Desialylation of Airway Epithelial Cells during Influenza Virus Infection Enhances Pneumococcal Adhesion via Galectin Binding
Researchers examined the possibility that galectins expressed in the airway epithelial cells might play a significant role in viral or pneumococcal adhesion to airway epithelial cells. [Mol Immunol] Abstract


Targeting LunX Inhibits Non-Small-Cell Lung Cancer Growth and Metastasis
Researchers report the identification of a novel candidate therapeutic target, LunX, as a molecule overexpressed in primary non-small-cell lung cancer and lymph node metastases that is associated with reduced postoperative survival. Functional studies demonstrated that LunX overexpression promoted lung cancer cell migration and proliferation by interactions with the chaperone protein 14-3-3. [Cancer Res] Abstract

Role of Nicotinic Acetylcholine Receptors in Cell Proliferation and Tumor Invasion in Broncho-Pulmonary Carcinomas
Scientists examined the localization of nicotinic acetylcholine receptors (nAChRs) in human lung tumors and, by using primary cultures of tumor cells derived from these tumors, determining the nAChR roles in cell proliferation and tumor invasion. [Lung Cancer] Abstract

β-Elemene Inhibited Expression of DNA Methyltransferase 1 through Activation of ERK1/2 and AMPKα Signaling Pathways in Human Lung Cancer Cells: The Role of Sp1
Researchers show that β-elemene inhibits human non-small cell lung carcinoma cell growth, and increased phosphorylation of ERK1/2, Akt and AMPKα. [J Cell Mol Med] Abstract

Hsp90 Inhibitor NVP-AUY922 Enhances the Radiation Sensitivity of Lung Cancer Cell Lines with Acquired Resistance to EGFR-Tyrosine Kinase Inhibitors
Scientists evaluated the radiosensitizing effect of the novel Hsp90 inhibitor, NVP-AUY922, on non-small cell lung cancer cell lines harboring epidermal growth factor receptor (EGFR) activating mutations and showing acquired resistance to EGFR-tyrosine kinase inhibitors via any of several mechanisms. [Oncol Rep] Abstract

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Efficacy and Adverse Effects of Drugs Used to Treat Adult Cystic Fibrosis
The authors bring together the various treatments being used to prolong and enhance the quality of life of cystic fibrosis patients. New concepts have been formed and some positive results in this direction have already led to the approval of cystic fibrosis transmembrane conductance regulator potentiator drug. [Expert Opin Drug Saf] Abstract

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Ventana Seeks FDA Premarket Approval for ALK IHC Companion Diagnostic to Benefit Lung Cancer Patients
Ventana Medical Systems, Inc. announced its FDA submission for premarket approval of the VENTANA ALK companion diagnostic assay. [Ventana Medical Systems, Inc.] Press Release

Trovagene Expands Collaboration with Genomac to Demonstrate Clinical Utility in Lung and Colorectal Cancer Treatment Monitoring
Trovagene, Inc. announced it will expand the clinical collaboration with Genomac Research Institute. Trovagene Precision Cancer MonitoringSM technology will be used in two prospective clinical studies for the early detection of emerging oncogene mutations indicative of resistance to targeted therapies used to treat colorectal and lung cancer. [Trovagene, Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cellular Therapy 2015 – 8th International Symposium on the Clinical Use of Cellular Products
March 19-20, 2015
Erlangen, Germany

NEW 2nd International Congress on Stem Cell and Cellular Therapies (ICSCCT)
October 15-18, 2015
Antalya, Turkey

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Director (California Institute for Regenerative Medicine)

Postdoctoral Fellow – Lung Cancer (MD Anderson Cancer Center)

Postdoctoral Fellow – Cystic Fibrosis Research (University of Tennessee Health Science Center)

Postdoctoral Research Fellow – Post-Transcriptional Gene Regulation Governing Cancer Cell Behavior (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Wnt Signaling in Development and Disease (Van Andel Research Institute)

Staff Scientist – Lung Cancer (University of Pennsylvania)

Postdoctoral Fellow – Cytokine-Induced Lung Inflammation (Cleveland Clinic Lerner Research Institute)

Postdoctoral Positions – Lung and Dermal Uptake Modeling (Karolinska Institutet)

Postdoctoral Position – Lung Cancer, Lung Regeneration and Lung Development (University of California – San Francisco)

PhD Students – Heart and Lung Research (Max Planck Institute for Heart and Lung Research)

Research Technologist – Media Development (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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