Volume 4.01 | Jan 15

Pulmonary Cell News 4.01 January 15, 2015
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Isogambogenic Acid Induces Apoptosis-Independent Autophagic Cell Death in Human Non-Small Cell Lung Carcinoma Cells
Scientists report that isogambogenic acid (iso-GNA) can induce apoptosis-independent autophagic cell death in human non-small cell lung carcinoma (NSCLC) cells. Several features of the iso-GNA-treated NSCLC cells indicated that iso-GNA induced autophagic cell death. [Sci Rep] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Degradable Polyphosphoester-Based Silver-Loaded Nanoparticles as Therapeutics for Bacterial Lung Infections
Well-defined Ag-loaded nanoparticles released silver in a controlled and sustained manner over five days, and displayed enhanced in vitro antibacterial activities against cystic fibrosis-associated pathogens and decreased cytotoxicity to human bronchial epithelial cells, in comparison to silver acetate. [Nanoscale] Abstract

Airway Epithelial Cell Integrity Protects from Cytotoxicity of P. aeruginosa Quorum-Sensing Signals
Pseudomonas aeruginosa N-3-oxo-dodecanoyl-L-homoserine lactone (C12) degradation and its effects on cells were monitored in various airway epithelial cell models grown under non-polarized and polarized conditions. C12 rapidly altered epithelial integrity and decreased gap junctional intercellular communication in non-polarized airway epithelial cells while other quorum-sensing molecules had no effect. [Am J Respir Cell Mol Biol] Abstract

Toxicity of Copper Oxide Nanoparticles in Lung Epithelial Cells Exposed at the Air-Liquid Interface Compared with In Vivo Assessment
The toxicity of spark-generated copper oxide nanoparticles was evaluated in human bronchial epithelial cells and lung adenocarcinoma cells using an in vitro air-liquid interface exposure system. [Toxicol In Vitro] Abstract

Integrin-Linked Kinase Mediates CTGF-Induced Epithelial to Mesenchymal Transition in Alveolar Type II Epithelial Cells
Alveolar type II epithelial cells were isolated from four weeks old connective tissue growth factor (CTGF)-overexpressing mice and control littermates, and cultured on Matrigel. Cells were transfected with integrin-linked kinase siRNA, and cell morphology and expression of cell differentiation markers were analyzed. [Pediatr Res] Abstract

LUNG CANCER

Curcumin Inhibits Proliferation-Migration of NSCLC by Steering Crosstalk between a Wnt Signaling Pathway and an Adherens Junction via EGR-1
A microarray analysis of differential genes by curcumin treatment was performed and the crucial pathways associated with non-small cell lung cancer were investigated. Function enrichment analysis indicated the differentially expressed genes were mainly involved in the steroid biosynthetic process and regulation of autophagy. [Mol Biosyst] Abstract

Down-Regulation of TIMP-1 Inhibits Cell Migration, Invasion, and Metastatic Colonization in Lung Adenocarcinoma
Researchers demonstrate that the expression level of tissue inhibitor metalloproteinase-1 (TIMP-1) positively associates with cell mobility, invasiveness, and metastatic colonization. Most notably, the novel mechanism in which TIMP-1 facilitates metastatic colonization through the mediation of pericellular polyFN1 assembly was revealed. [Tumor Biol] Abstract

Luteolin Acts as a Radiosensitizer in Non-Small Cell Lung Cancer Cells by Enhancing Apoptotic Cell Death through Activation of a p38/ROS/Caspase Cascade
Treatment with luteolin or γ-ionizing radiation (IR) induced non-small cell lung cancer cell death in vitro, but the combination of luteolin pre-treatment and IR was more effective than either agent alone. [Int J Oncol] Abstract

The Combination of Hsp90 Inhibitor 17AAG and Heavy-Ion Irradiation Provides Effective Tumor Control in Human Lung Cancer Cells
SQ5 human lung tumor cells were used in vitro for clonogenic cell survival and in vivo for tumor growth delay measurement using a mouse xenograft model after 17-allylamino-17-demethoxygeldanamycin pretreatment and carbon ion irradiation. [Cancer Med] Abstract

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REVIEWS
Respiratory Tissue Engineering: Current Status and Opportunities for the Future
The authors provide a concise summary of the field of respiratory tissue engineering to date. An initial overview of airway anatomy and physiology is given, followed by a description of the stem cell populations and signaling processes involved in parenchymal healing and tissue repair. [Tissue Eng Part B Rev] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
INDUSTRY NEWS
Lung Therapeutics, Inc. Granted Orphan Drug Designation in the European Union for LTI-01
Lung Therapeutics, Inc. announced that the European Commission has granted the company’s lead drug candidate, LTI-01, orphan medicinal product designation for the treatment of empyema, a complication of pneumonia. [Lung Therapeutics, Inc.] Press Release

CheckMate -017, A Phase III Study of Opdivo (Nivolumab) Compared to Docetaxel in Patients with Second-Line Squamous Cell Non-small Cell Lung Cancer, Stopped Early
Bristol-Myers Squibb Company announced that an open-label, randomized Phase III study evaluating Opdivo versus docetaxel in previously treated patients with advanced, squamous cell non-small cell lung cancer was stopped early because an assessment conducted by the independent Data Monitoring Committee concluded that the study met its endpoint, demonstrating superior overall survival in patients receiving Opdivo compared to the control arm. [Bristol-Myers Squibb Company] Press Release

Aradigm Granted Key Composition of Matter Patents for Pulmaquin in Europe and Australia
Aradigm Corporation announced that the European Patent Office has issued an important new composition of matter patent entitled “Dual Action, Inhaled Formulations Providing Both an Immediate and Sustained Release Profile,” to Aradigm for formulations of liposomal and free ciprofloxacin. [Aradigm Corporation] Press Release

PharmaMar Will Start a Phase III Study of PM1183 in Combination with Doxorubicin in Relapsed SCLC
Zeltia announced that its pharmaceutical division PharmaMar will start a Phase III trial with PM1183 in combination with doxorubicin against topotecan in SCLC, given the activity observed in an interim analysis of an ongoing Phase Ib trial. [Zeltia] Press Release

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POLICY NEWS
Nature Owner Merges with Publishing Giant
Consolidation is afoot in scientific publishing. Macmillan Science and Education, the London-based publisher of Nature and Scientific American, will merge with Berlin-based Springer Science+Business Media, one of the world’s largest science publishers. [Nature News] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW CIRM 2.0 Free Webinar – Changing the Way We Work
January 21, 2015 12:00 PM PST
Online

NEW 4th International Conference on Immunochemotherapy
April 16-17, 2015
Philadelphia, United States

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Lung Cancer (MD Anderson Cancer Center)

NEW Postdoctoral Fellow – Cystic Fibrosis Research (University of Tennessee Health Science Center)

Postdoctoral Research Fellow – Post-Transcriptional Gene Regulation Governing Cancer Cell Behavior (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Wnt Signaling in Development and Disease (Van Andel Research Institute)

Staff Scientist – Lung Cancer (University of Pennsylvania)

Postdoctoral Fellow – Cytokine-Induced Lung Inflammation (Cleveland Clinic Lerner Research Institute)

Postdoctoral Positions – Lung and Dermal Uptake Modeling (Karolinska Institutet)

Postdoctoral Position – Lung Cancer, Lung Regeneration and Lung Development (University of California – San Francisco)

Postdoctoral Positions – Lung Development and Progenitor Cell Biology (Columbia University)

Postdoctoral Researcher – Chromatin and Epigenetic Regulation (Van Andel Research Institute)

PhD Students – Heart and Lung Research (Max Planck Institute for Heart and Lung Research)

Research Technologist – Media Development (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)


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