Volume 4.00 | Jan 8

Pulmonary Cell News 4.00 January 8, 2015
Pulmonary Cell News
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Scientists Zero in on How Lung Cancer Spreads
Scientists have taken microscopic images revealing that the protein ties tethering cells together are severed in lung cancer cells – meaning they can break loose and spread. [Press release from Cancer Research UK discussing publication in Cell Reports] Press Release | Full Article | Graphical Abstract
Model the Human Respiratory Epithelium with PneumaCult™-ALI. Click to View Data.
PUBLICATIONS (Ranked by impact factor of the journal)
Notch2 Is Required for Inflammatory Cytokine-Driven Goblet Cell Metaplasia in the Lung
To identify mechanisms regulating basal cell fate, researchers developed a screenable 3D culture system of airway epithelial morphogenesis. They performed a high-throughput screen using a collection of secreted proteins and identified inflammatory cytokines that specifically biased basal cell differentiation toward a goblet cell fate, culminating in enhanced mucus production. [Cell Rep] Full Article | Graphical Abstract

Lung-Derived SSEA-1+ Stem/Progenitor Cells Inhibit Allergic Airway Inflammation in Mice
The effects of SSEA-1+ (stage-specific embryonic antigen-1) pulmonary stem/progenitor cells was studied in an in vivo model of ovalbumin-induced allergic inflammation and an in vitro model of cell-based regulation using flow cytometry, real-time PCR, and immune-blotting. [Allergy] Abstract

17β-Estradiol Suppresses Lipopolysaccharide-Induced Acute Lung Injury through PI3K/Akt/SGK1 Mediated Up-Regulation of Epithelial Sodium Channel (ENaC) In Vivo and In Vitro
Investigators assessed the role of ENaC and the PI3K/Akt/SGK1 signaling pathway in 17β-estradiol therapy in attenuating lipopolysaccharide-induced acute lung injury. [Respir Res] Abstract | Full Article

Cell Surface Marker Profiling of Human Tracheal Basal Cells Reveals Distinct Subpopulations, Identifies MST1/MSP as a Mitogenic Signal, and Identifies New Biomarkers for Lung Squamous Cell Carcinomas
Scientists investigated tracheal basal cell diversity and to identify new signaling pathways that regulate basal cell behavior. They identified 105 surface markers, with 47 markers identifying potential subpopulations. [Respir Res] Abstract | Full Article

Microarray Analysis of Long Non-Coding RNAs in COPD Lung Tissue
The authors provide the description of genome-wide long non-coding RNAs expression in the lung tissue of non-smokers without chronic obstructive pulmonary disease (COPD), of smokers without COPD and of smokers with COPD. [Inflamm Res] Abstract


The Kinase Activity of the Ser/Thr Kinase BUB1 Promotes TGF-β Signaling
Researchers identified the kinase BUB1 (budding uninhibited by benzimidazoles-1) as a key mediator of transforming growth factor-β (TGF-β) signaling. A small-molecule inhibitor of the kinase activity of BUB1 administration to mice bearing lung carcinoma xenografts reduced the amount of phosphorylated SMAD2 in tumor tissue. [Sci Signal] Abstract | Press Release

PKCδ-iPLA2-PGE2-PPARγ Signaling Cascade Mediates TNF-α Induced Claudin 1 Expression in Human Lung Carcinoma Cells
Investigators elucidated the molecular mechanisms involved in TNF-α induced Claudin 1 (CLDN1) expression in human lung carcinoma A549 cells. Chemical inhibition or siRNA downregulation of Src, PI3K, Akt, MAPKs, NFκB, caspase and PKC demonstrated that PKC, specifically PKCδ, is required for TNF-α induced CLDN1 expression. [Cell Signal] Abstract

Carfilzomib Demonstrates Broad Anti-Tumor Activity in Pre-Clinical Non-Small Cell and Small Cell Lung Cancer Models
A diverse panel of human lung cancer cell lines and a SHP77 small cell lung cancer xenograft model were used to investigate the anti-tumor activity of carfilzomib (CFZ). CFZ treatment inhibited both the constitutive proteasome and the immunoproteasome in lung cancer cell lines. [J Exp Clin Cancer Res]
Abstract | Full Article

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Virus-Induced Modulation of Lower Airway Diseases: Pathogenesis and Pharmacologic Approaches to Treatment
The authors review the role of viruses in lower airway diseases, including the current understanding on pathways by which they may cause remodeling and trigger acute exacerbations. [Pharmacol Ther] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
SOTIO Launches First Clinical Trial of a New Treatment for Lung Cancer
SOTIO announced that the first patient has been enrolled into its recently launched international study in lung cancer a Phase I/II clinical trial using its Dendritic Cell Vaccine, an active cellular immunotherapy treatment. [SOTIO] Press Release

Cempra Announces Positive Topline Phase III Clinical Results for Oral Solithromycin in the Treatment of Community Acquired Bacterial Pneumonia
Cempra, Inc. announced positive topline results from a global, pivotal Phase III clinical trial of solithromycin oral capsules in the treatment of patients with community acquired bacterial pneumonia. [Cempra, Inc.] Press Release

OncoGenex to Regain Rights to Custirsen from Teva
OncoGenex Pharmaceuticals, Inc. announced that it has executed an initial agreement with Teva Pharmaceutical Industries Ltd. to regain rights to custirsen, an investigational compound currently being evaluated in Phase III clinical development as a treatment for prostate and lung cancers. [OncoGenex Pharmaceuticals, Inc.] Press Release

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NEW Keystone Symposium – Endoderm Lineages in Development and Disease
February 8-13, 2015
Keystone, United States

NEW SelectBio Stem Cells in Drug Discovery
June 2-3, 2015
Cambridge, United Kingdom

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Postdoctoral Research Fellow – Post-Transcriptional Gene Regulation Governing Cancer Cell Behavior (Fred Hutchinson Cancer Research Center)

NEW Postdoctoral Fellow – Wnt Signaling in Development and Disease (Van Andel Research Institute)

Staff Scientist – Lung Cancer (University of Pennsylvania)

Postdoctoral Fellow – Cytokine-Induced Lung Inflammation (Cleveland Clinic Lerner Research Institute)

Postdoctoral Positions – Lung and Dermal Uptake Modeling (Karolinska Institutet)

Postdoctoral Position – Lung Cancer, Lung Regeneration and Lung Development (University of California – San Francisco)

Postdoctoral Positions – Lung Development and Progenitor Cell Biology (Columbia University)

Postdoctoral Researcher – Chromatin and Epigenetic Regulation (Van Andel Research Institute)

PhD Students – Heart and Lung Research (Max Planck Institute for Heart and Lung Research)

Research Technologist – Media Development (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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