Volume 3.49 | Dec 18

Pulmonary Cell News 3.49 December 18, 2014
Pulmonary Cell News
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Genetic Modifiers of EGFR Dependence in Non-Small Cell Lung Cancer
Researchers applied an unbiased, ORF-based screen to identify genetic modifiers of epidermal growth factor receptor (EGFR) dependence in EGFR-mutant non-small cell lung cancer cells. [Proc Natl Acad Sci USA] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Streptococcus pneumoniae-Induced Oxidative Stress in Lung Epithelial Cells Depends on Pneumococcal Autolysis and Is Reversible by Resveratrol
Scientists observed a significant induction of oxidative stress induced by S. pneumoniae in vivo, ex vivo, and in vitro. Upon stimulation, the oxidant responsive transcription factor Nrf2 was activated, and catalase was upregulated via Nrf2. [J Infect Dis] Abstract

Lymphotoxin β Receptor Signaling Induces IL-8 Production in Human Bronchial Epithelial Cells
Scientists aimed to elucidate the molecular mechanism of LIGHT-induced cytokine/chemokine production by bronchial epithelial cells. [PLoS One] Full Article

Arsenite-Induced Pseudo-Hypoxia Results in Loss of Anchorage-Dependent Growth in BEAS-2B Pulmonary Epithelial Cells
Researchers modeled arsenic-exposed human pulmonary epithelial cells in vitro with BEAS-2B, a non-malignant lung epithelial cell line. Constant exposure to 1 µM arsenite resulted in the early loss of anchorage-dependent growth, measured by soft agar colony formation, beginning at six weeks of exposure. [PLoS One] Full Article

Role of Reactive Oxygen Species in Arsenic-Induced Transformation of Human Lung Bronchial Epithelial (BEAS-2B) Cells
Scientists used expressions of catalase and superoxide dismutase 2 to decrease reactive oxygen species (ROS) level and investigated their role in the process of arsenic-induced cell transformation. They show that inhibition of ROS by antioxidant enzymes decreased arsenic-induced cell transformation, demonstrating that ROS are important in this process. [Biochem Biophys Res Commun] Abstract

Retinoic Acid Promotes Primary Fetal Alveolar Epithelial Type II Cell Proliferation and Differentiation to Alveolar Epithelial Type I Cells
Researchers observed the effect of retinoic acid on the proliferation and differentiation of primary fetal alveolar epithelial type II cells. [In Vitro Cell Dev Biol Anim] Abstract


Long Noncoding RNA ANRIL Promotes Non Small Cell Lung Cancer Cells Proliferation and Inhibits Apoptosis by Silencing KLF2 and P21 Expression
Researchers reported that ANRIL expression was increased in non small cell lung cancer tissues and its expression level was significantly correlated with TNM stages and tumor size. [Mol Cancer Ther] Abstract

Enhanced Cytotoxic Activity of Cetuximab in EGFR-Positive Lung Cancer by Conjugating with Gold Nanoparticles
Scientists report that conjugation of cetuximab (C225) with gold nanoparticles enhances the cytotoxicity of C225 in non-small cell lung cancer both in vitro and in vivo. [Sci Rep] Full Article

Biological and Clinical Significance of Epigenetic Silencing of MARVELD1 Gene in Lung Cancer
Researchers found the reduced MARVELD1 expression significantly correlated with diagnostic histopathology and malignant degree of lung cancers. DNA hypermethylation and histone deacetylation synergistically inactivated MARVELD1 gene in lung cancer cells. [Sci Rep] Full Article

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Respiratory Epithelial Cells Orchestrate Pulmonary Innate Immunity
The epithelial surfaces of the lungs are in direct contact with the environment and are subjected to dynamic physical forces as airway tubes and alveoli are stretched and compressed during ventilation. Mucociliary clearance in conducting airways, reduction of surface tension in the alveoli, and maintenance of near sterility have been accommodated by the evolution of a multi-tiered innate host-defense system. [Nat Immunol] Abstract

Receptor-Mediated Endocytosis of Macromolecules and Strategy to Enhance Their Transport in Alveolar Epithelial Cells
The alveolar epithelium is comprised of type I and type II cells. Understanding the transport mechanisms in these cells is essential for the development of efficient pulmonary delivery systems of therapeutic macromolecules. [Expert Opin Drug Deliv] Abstract

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BC Cancer Agency Researchers Co-Lead $60 Million National Initiative for Innovative Cancer Treatments
BC Cancer Agency researchers will play a key role in the first Network of Centres of Excellence devoted to cancer research, announced today with a $25 million commitment from the Government of Canada and an additional $35 million from partners across the country. [BC Cancer Agency] Press Release

FDA Approves Drug that Extends Survival in the Most Common Type of Lung Cancer
The Food and Drug Administration (FDA) approved a new drug to treat non-small-cell lung cancer (NSCLC), offering people new hope in fighting the disease. The drug, Cyramza, was tested on more than 1,200 people with NSCLC whose cancer worsened during or after first-line chemotherapy. [UCLA] Editorial

Batu Biologics Submits Investigational New Drug Application for Lung Cancer Anti-Angiogenic Immunotherapy with FDA
Batu Biologics announced the filing of an investigational drug application with the U.S. Food and Drug Administration (FDA) for its lead immune therapy, ValloVax. [Batu Biologics (Business Wire)] Press Release

Inovio Pharmaceuticals Initiates DNA Immunotherapy Trial for Breast, Lung and Pancreatic Cancers
Inovio Pharmaceuticals, Inc. announced it has initiated a Phase I trial of its hTERT DNA immunotherapy alone or in combination with Inovio’s IL-12 immune activator in adults with breast, lung, or pancreatic cancer at high risk of relapse after surgery and other cancer treatments. [Inovio Pharmaceuticals, Inc.] Press Release

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Passage of Spending Bill Brings More Lung Cancer Research Funding
Lung Cancer Alliance announced that another $10.5 million for lung cancer research was approved by Congress. [Lung Cancer Alliance (PR Newswire Association LLC)] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Radiation Biology and Cancer: From Molecular Responses to the Clinic
February 5-7, 2015
Essen, Germany

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Staff Scientist – Lung Cancer (University of Pennsylvania)

NEW Postdoctoral Fellow – Cytokine-Induced Lung Inflammation (Cleveland Clinic Lerner Research Institute)

NEW Postdoctoral Positions – Lung and Dermal Uptake Modeling (Karolinska Institutet)

NEW Postdoctoral Position – Lung Cancer, Lung Regeneration and Lung Development (University of California – San Francisco)

Postdoctoral Positions – Lung Development and Progenitor Cell Biology (Columbia University)

Postdoctoral Research Associate – Lung and Vascular Biology (University of Illinois Chicago College of Medicine)

Postdoctoral Researcher – Chromatin and Epigenetic Regulation (Van Andel Research Institute)

PhD Students – Heart and Lung Research (Max Planck Institute for Heart and Lung Research)

Research Technologist – Media Development (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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