Volume 3.47 | Dec 4

Pulmonary Cell News 3.47 December 4, 2014
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Secretory Phospholipases A2 Are Secreted from Ciliated Cells and Increase Mucin and Eicosanoid Secretion from Goblet Cells
Researchers used IL-13 transformed highly enriched goblet cells and differentiated human bronchial epithelial cell culture to evaluate the relative contribution of ciliated and goblet cells to airway secretory phospholipases A2 generation and response. [Chest] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
MicroRNA-19a Enhances Proliferation of Bronchial Epithelial Cells by Targeting TGFβR2 Gene in Severe Asthma
Scientists determined the role of miRNAs in regulating proliferation of bronchial epithelial cells obtained from severe asthmatic subjects in comparison to cells obtained from mild asthmatics and healthy controls. [Allergy] Abstract

Effects in Cigarette Smoke Stimulated Bronchial Epithelial Cells of a Corticosteroid Entrapped into Nanostructured Lipid Carriers
Nanostructured lipid carriers (NLC) containing Fluticasone propionate were prepared and their biocompatibility and effects in a human bronchial epithelial cell line stimulated with cigarette smoke extracts were tested. Biocompatibility studies showed that the NLC did not induce cell necrosis or apoptosis. [J Nanobiotechnology] Abstract | Full Article

Genotoxic and Epigenotoxic Effects of Fine Particulate Matter from Rural and Urban Sites in Lebanon on Human Bronchial Epithelial Cells
Using two different particulate matter (PM)2.5-0.3 samples collected at an urban and a rural site, scientists examined genotoxic/epigenotoxic effects of PM exposure within a human bronchial epithelial cell line. [Environ Res] Abstract

SILAC-Based Quantitative Proteomic Analysis of Human Lung Cell Response to Copper Oxide Nanoparticles
Researchers evaluated the response of BEAS-2B human lung cells to Copper (II) oxide (CuO) nanoparticles (NP), using stable isotope labeling by amino acids in cell culture (SILAC)-based proteomics and phosphoproteomics. Pathway modeling of the protein differential expression showed that CuO NP affect proteins relevant in cellular function and maintenance, protein synthesis, cell death and survival, cell cycle and cell morphology. [PLoS One] Full Article

Delay of Airway Epithelial Wound Repair in COPD Is Associated with Airflow Obstruction Severity
Researchers determined if airway epithelial wound repair of airway epithelium is abnormal in chronic obstructive pulmonary disease (COPD). They determined the mean speed of wound closure and cell proliferation index, matrix metalloprotease (MMP)-2, MMP-9 and cytokines levels in supernatants of bronchial epithelial cells 18 hours after cell wounding. [Respir Res] Full Article

Toxicity of Nanoparticles Embedded in Paints Compared to Pristine Nanoparticles, In Vitro Study
The in vitro toxicity of three pristine ENPs, three aged paints containing ENPs and control paints without ENPs were compared. Cytotoxicity was assessed using a biculture consisting of human bronchial epithelial cells and human monocytic cells to determine subtoxic concentrations. [Toxicol Lett] Abstract

LUNG CANCER

Downregulation of miR-25 Modulates Non-Small Cell Lung Cancer Cells by Targeting CDC42
Researchers investigated the functional role of miRNA-25 in non-small cell lung cancer (NSCLC) cells. Quantitative real-time polymerase chain reaction was used to detect the expression of miR-25 in NSCLC cell lines and 11 pairs of human NSCLC and non-cancerous tissues. [Tumor Biol] Abstract

Excision Repair Cross Complementation Group 1 Is a Chemotherapy-Tolerating Gene in Cisplatin-Based Treatment for Non-Small Cell Lung Cancer
Researchers evaluated the biological functions of excision repair cross complementation group 1 in cell proliferation, cell cycle, invasion and cisplatin response of non-small cell lung cancer cells. [Int J Oncol] Abstract

MicroRNA-449a Suppresses Non-Small Cell Lung Cancer
Scientists transfected microRNA-449a mimic and inhibitor in lung cancer cell line A549, and used western blot to determine the expression level of apoptosis-related molecules Bcl-2 and p53. [Cell Biochem Biophys] Abstract

Maslinic Acid Induces Mitochondrial Apoptosis and Suppresses HIF-1α Expression in A549 Lung Cancer Cells under Normoxic and Hypoxic Conditions
The apoptotic effects of maslinic acid (MA) at 4, 8, 16, 32 and 64 μmol/L on human lung cancer A549 cells under normoxic and hypoxic conditions were examined. MA at 4-64 and 16-64 μmol/L lowered Bcl-2 expression under normoxic and hypoxic conditions, respectively. [Molecules] Abstract | Download Full Article

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REVIEWS
Wnt and FGF Mediated Epithelial Mesenchymal Crosstalk during Lung Development
The authors describe the molecular processes governing lung development with an emphasis on the current knowledge on the role of Wnt and Fgf signaling in lung epithelial differentiation. [Dev Dyn] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
INDUSTRY NEWS
Lung Therapeutics, Inc. Receives FDA Orphan Drug Designation for Lead Drug Candidate LTI-01
Lung Therapeutics, Inc. announced the company has received orphan drug designation from the U.S. Food & Drug Administration (FDA) for the company’s lead drug candidate, LTI-01, in the treatment of empyema, typically a complication of pneumonia. [Lung Therapeutics, Inc.] Press Release

FDA Approves PulmoFlow’s Tobramycin & Nebulizer Combination for Cystic Fibrosis
The FDA granted final approval of PulmoFlow, Inc.’s New Drug Application for Kitabis Pak – a co-packaging of generic tobramycin inhalation solution with a PARI LC PLUS® Nebulizer. This is the first nebulized drug and device combination to be approved for patients with cystic fibrosis. [PARI International] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 4th Annual Cell Line Engineering & Development Asia
May 19-22, 2015
Shanghai, China

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Researcher – Small Cell Lung Cancer (Johns Hopkins University)

NEW Scientist Position – Genetic Alterations Involved in Lung Cancer (Dana-Farber Cancer Institute)

NEW Research Technologist – Media Development (STEMCELL Technologies Inc.)

Postdoctoral Positions – Lung Development and Progenitor Cell Biology (Columbia University)

Postdoctoral Research Associate – Lung and Vascular Biology (University of Illinois Chicago College of Medicine)

Postdoctoral Researcher – Chromatin and Epigenetic Regulation (Van Andel Research Institute)

Head of Cellular and Molecular Therapies Laboratory (NHS Blood & Transplant)

PhD Students – Heart and Lung Research (Max Planck Institute for Heart and Lung Research)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)


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