Highly Effective New Anti-Cancer Drug Shows Few Side Effects – In Mice|
A new drug, known as OTS964, can eradicate aggressive human lung cancers transplanted into mice. The drug, given as a pill or by injection, inhibits the action of a protein that is overproduced by several tumor types, including lung and breast, but is rarely expressed in healthy adult tissues. Without this protein, cancer cells begin the cell-division process but fail to complete it and die. [Press release from University of Chicago discussing publication in Science Translational Medicine] Press
|PUBLICATIONS (Ranked by impact factor of the journal)|
RBCs Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation|
Researchers set out to determine the mechanisms of lung EC High Mobility Group Box 1 (HMGB1) release following exposure to RBCs and to determine whether RBC transfusion increases susceptibility to lung inflammation in vivo through release of the danger signal HMGB1. [Am J Respir Crit Care Med] Abstract
Resolvin D1 Attenuates Polyinosinic-Polycytidylic Acid-Induced Inflammatory Signaling in Human Airway Epithelial Cells via TAK1
Investigators identified the mechanism whereby resolvin D1 disrupts inflammatory mediator production induced by the viral mimic polyinosinic-polycytidylic acid in primary human lung epithelial cells. [J Immunol] Abstract
Superiority of Combined PDE3/PDE4 Inhibition Over PDE4 Inhibition Alone on Glucocorticoid- and Long-Acting β2-Adrenoceptor Agonist-Induced Gene Expression in Human Airway Epithelial Cells
Using models of cAMP- and glucocorticoid-induced transcription in human bronchial epithelial BEAS-2B cells, researchers show that combining inhibitors of phosphodiesterase (PDE) 3 and PDE4 provides greater benefits compared to inhibiting either PDE alone. [Mol Pharmacol] Abstract
Enhanced Phenotypic Alterations of Alveolar Type II Cells in Response to Aflatoxin G1-Induced Lung Inflammation
Increased MHC-II expression in alveolar epithelium was observed and associated with enhanced T cells (Tregs) infiltration in mouse lung tissues with Aflatoxin G1 (AFG1)-induced inflammation. This provides a link between phenotypically altered alveolar type II cells and Treg activity in the AFG1-induced inflammatory microenvironment. [J Cell Physiol] Abstract
Therapeutic Effects of Amniotic Fluid-Derived Mesenchymal Stromal Cells on Lung Injury in Rats with Emphysema
Researchers analyzed the phenotypic characteristics, differentiation potential, and karyotype of rat amniotic fluid-derived mesenchymal stromal cells (rAFMSCs), which were isolated from pregnant Sprague-Dawley rats. The ability of rAFMSCs to differentiate was measured, and the apoptosis of type II alveolar epithelial cells was evaluated. [Resp Res] Full Article
A Novel Antagonist to the Inhibitors of Apoptosis (IAPs) Potentiates Cell Death in EGFR-Overexpressing Non-Small-Cell Lung Cancer Cells
In the effort to develop an efficient chemotherapy drug for the treatment of non-small-cell lung cancer (NSCLC), scientists analyzed the anti-tumorigenic effects of a novel small molecule targeting the inhibitor of apoptosis, HM90822B, on NSCLC cells. HM90822B efficiently decreased IAP expression, especially that of XIAP and survivin, in several NSCLC cells. [Cell Death Dis] Full Article
Mcl-1 Promotes Lung Cancer Cell Migration by Directly Interacting with VDAC to Increase Mitochondrial Ca2+ Uptake and Reactive Oxygen Species Generation
Scientists report the physiological significance of an interaction between Mcl-1 and the mitochondrial outer membrane-localized voltage-dependent anion channel (VDAC) in non-small cell lung carcinoma cell lines.
[Cell Death Dis] Full Article
Mast Cell Exosomes Promote Lung Adenocarcinoma Cell Proliferation – Role of KIT-Stem Cell Factor Signaling
The authors demonstrate that exosomes from mast cells can be taken up by lung cancer cells. Exosomes were isolated from the human mast cell line, HMC-1, and uptake of PKH67-labelled exosomes by the lung epithelial cell line, A549, was examined using flow cytometry and fluorescence microscopy. [Cell Commun Signal]
Critical Role of Spns2, a Sphingosine-1-Phosphate Transporter, in Lung Cancer Cell Survival and Migration
Researchers show that ectopic Spns2 expression induced apoptosis and its knockdown enhanced cell migration in non-small cell lung cancer cells. [PLoS One] Full Article
Effects of AKT Inhibition on HGF-Mediated Erlotinib Resistance in Non-Small Cell Lung Cancer Cell Lines
Investigators determined whether inhibition of AKT signaling could augment erlotinib activity and abrogate HGF-mediated resistance. The effects of MK-2206, a selective AKT inhibitor, were evaluated in combination with erlotinib on a large panel of 13 lung cancer cell lines containing different EGFR or KRAS abnormalities.
[J Cancer Res Clin Oncol] Abstract
Mucins in Lung Cancer: Diagnostic, Prognostic and Therapeutic Implications|
Several strategies targeting mucin expression and function are currently being investigated to control lung cancer progression. The authors review the importance of mucins both in the normal bronchial epithelial cells and malignant tumors of the lung and their contribution in the diagnosis and prognosis of lung cancer patients.
[J Thorac Oncol] Abstract
Small Cell Lung Cancer: Where Do We Go from Here?
The authors review the current state of small cell lung cancer (SCLC) treatment, recent advances in current understanding of the underlying disease biology, and opportunities to advance translational research and therapeutic approaches for patients with SCLC. [Cancer] Abstract
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