Volume 3.32 | Aug 21

Pulmonary Cell News 3.32 August 21, 2014
Pulmonary Cell News
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RNA Combination Therapy for Lung Cancer Offers Promise for Personalized Medicine
Researchers report that they have successfully delivered small RNA therapies in a clinically relevant mouse model of lung cancer to slow and shrink tumor growth. Their research offers promise for personalized RNA combination therapies to improve therapeutic response. [Press release from Massachusetts Institute of Technology discussing online prepublication in Proceedings of the National Academy of Sciences USA]
Press Release
| Abstract
Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
PUBLICATIONS (Ranked by impact factor of the journal)
Long-Term Survival of Influenza Virus Infected Club Cells Drives Immunopathology
Scientists propose a model in which infected, surviving club cells establish a proinflammatory environment aimed at controlling virus levels, but at the same time contribute to lung pathology. [J Exp Med]
| Press Release

IL-6/STAT3 Promotes Regeneration of Airway Ciliated Cells from Basal Stem Cells
Using a clonal 3D organoid assay, investigators found that IL-6 stimulated, and Stat3 inhibitors reduced, the generation of ciliated vs. secretory cells from basal cells. [Proc Natl Acad Sci USA] Abstract | Full Article

CCN1 Secretion and Cleavage Regulate the Lung Epithelial Cell Functions after Cigarette Smoke
Scientists report a novel paradigm potentially involved in the development of epithelial cell death and tissue loss in cigarette smoking-associated emphysema. [Am J Physiol Lung Cell Mol Physiol] Full Article

A New 9-Alkyladenine-Cyclic Methylglyoxal Diadduct Activates Wt- and F508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) In Vitro and In Vivo
Investigators report on the synthesis of 9-alkyladenine derivatives and analogues of their previously discovered activator of wt-CFTR and F508del-CFTR, GPact-11a, and the identification of a new activator of these channels, GPact-26a, through various flux assays on human airway epithelial CF and non-CF cell lines and in vivo measurement of rat salivary secretion. [Eur J Med Chem] Abstract | Graphical Abstract

Indacaterol Inhibits the Tumor Cell Invasiveness and the Expression of MMP-9 by Suppressing IKK/NF-KappaB Activation
Researchers showed that indacaterol significantly inhibited TNF-α/NF-κB-induced cell invasiveness and migration in a human cancer cell line and propose that indacaterol may inhibit NF-κB activity in a β-arrestin2-dependent manner, preventing further lung damage and improving lung function in chronic obstructive pulmonary disorder patients. [Mol Cells] Abstract | Full Article

Secretoglobin 3A2 Attenuates Lipopolysaccharide-Induced Inflammation through Inhibition of ERK and JNK Pathways in Bronchial Epithelial Cells
Scientists demonstrate the novel biological activity of secretoglobin 3A2, which attenuated lipopolysaccharide-induced inflammation in bronchial epithelial cells through inhibition of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activation. [Inflammation] Abstract


The Inhibitor of Kappa B Kinase-Epsilon Regulates MMP-3 Expression Levels and Can Promote Lung Metastasis
Researchers report that lung carcinoma cells ectopically expressing high levels of the receptor for the type I insulin like growth factor receptor (M27R cells) had a significant reduction in matrix metalloproteinases (MMP)-3 expression levels and this coincided with reduced metastasis to the lung. [Oncogenesis] Full Article

TIP30 Nuclear Translocation Negatively Regulates EGF-Dependent Cyclin d1 Transcription in Human Lung Adenocarcinoma
Investigators demonstrate that TIP30, a tumor suppressor protein, translocated into the nucleus of human lung adenocarcinoma cells following epidermal growth factor (EGF) treatment, and the selective inhibitors of EGFR signaling pathways blocked this effect. [Cancer Lett] Abstract

Singly Protonated Dehydronorcantharidin Silver Coordination Polymer Induces Apoptosis of Lung Cancer Cells via Reactive Oxygen Species-Mediated Mitochondrial Pathway
Researchers provide evidence that Ag-SP-DNC, a novel silver and singly protonated dehydronorcantharidin complex, elicits a reactive oxygen species-mediated mitochondrial apoptosis in lung cancer cells.
[Eur J Med Chem]
Abstract | Graphical Abstract

Crotoxin Induces Apoptosis and Autophagy in Human Lung Carcinoma Cells In Vitro via Activation of the p38MAPK Signaling Pathway
Investigators tested human lung squamous carcinoma SK-MES-1 cells and then evaluated the cytotoxicity of crotoxin in both MTT and colony formation assays. [Acta Pharmacol Sin] Abstract

Model the Human Respiratory Epithelium with PneumaCult™-ALI. Click to View Data.
MicroRNAs: A New Key in Lung Cancer
The authors review on the roles of miRNAs for possible ways to prevent lung cancer in clinical trials.
[Cancer Chemother Pharmacol]

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
LCA Applauds Launch of Innovative Trial at National Cancer Institute
The Lung Cancer Alliance (LCA) praised the National Cancer Institute’s new trial that will focus on the prevention of recurrence in two specific types of lung cancers when they are caught at early stage and surgically removed. [Lung Cancer Alliance] Press Release

AstraZeneca Advances Tralokinumab to Phase III in Severe Asthma
AstraZeneca announced the start of the Phase III program for tralokinumab, a potential treatment for patients with severe, inadequately controlled asthma, developed by MedImmune, the company’s global biologics research and development arm. [MedImmune, LLC] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 21st Stem Cell Network Workshop – Bioengineering and Stem Cells
September 23, 2014
Sydney, Australia

NEW 13th Annual AACR International Conference on Frontiers in Cancer Prevention Research
September 28-October 1, 2014
New Orleans, United States

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Postdoctoral Fellow – Advanced Drug Delivery and Biomaterials (Louvain Drug Research Institute)

Research Assistant – Lung Cancer (University of Cambridge)

Postdoctoral Research Fellow – Lund Diseases (University of Calgary)

Postdoctoral Fellow – Development of the Esophagus and Lung (University of Rochester Medical Center)

Postdoctoral Fellowship – Lung Cancer (University College Dublin)

Postdoctoral Scientist – Transcriptional Networks in Lung Cancer (Cancer Research UK Manchester Institute)

Postdoctoral Fellow – Mechanisms of Lung Alveoli Epithelial Repair (University of Illinois Chicago College of Medicine)

Postdoctoral Research Associate – Lung Development Research (Women and Infants Hospital of Rhode Island)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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