Volume 3.29 | Jul 31

Pulmonary Cell News 3.29 July 31, 2014
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Yap Tunes Airway Epithelial Size and Architecture by Regulating the Identity, Maintenance, and Self-Renewal of Stem Cells
Researchers show that Yes-associated protein 1 (Yap) is required for the actual maintenance of an adult mammalian stem cell. Without Yap, adult airway basal stem cells are lost through their unrestrained differentiation, resulting in the simplification of a pseudostratified epithelium into a columnar one. [Dev Cell] Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
The Hippo Pathway Effector Yap Controls Patterning and Differentiation of Airway Epithelial Progenitors
Scientists provide evidence that the Hippo pathway effector Yap is a key regulator of this process in the developing lung. They show that when epithelial tubules are forming and branching, a nucleocytoplasmic shift in Yap localization marks the boundary between the airway and the distal lung compartments. [Dev Cell]
Abstract | Graphical Abstract

Oxidative Stress and Aromatic Hydrocarbon Response of Human Bronchial Epithelial Cells Exposed to Petro- or Biodiesel Exhaust Treated with a Diesel Particulate Filter
Researchers exposed well-differentiated normal human bronchial epithelial cells to fresh, complete exhaust from a diesel engine run with and without a diesel particulate filter and using either traditional petro- or alternative biodiesel. [Toxicol Sci] Abstract

Ozone Induced Airway Epithelial Cell Death, the Neurokinin-1 Receptor Pathway and the Postnatal Developing Lung
Scientists hypothesized that substance P, neurokinin-1 receptor (SP/NK-1R) pathway expression is disrupted by acute ozone exposure during postnatal airway development. They found that ozone increases the SP/NK-1R pathway expression in conducting airways and overall inflammation and cell death in distal airways. [Am J Physiol Lung Cell Mol Physiol] Abstract

Alpha-Klotho Protects against Oxidative Damage in Pulmonary Epithelia
Investigators used in vivo and in vitro models to test whether αKlotho protects lung epithelia against injury. Studies were performed in A549 lung epithelial cells and/or primary culture of alveolar epithelial cells. [Am J Physiol Lung Cell Mol Physiol] Abstract

Astragalin Inhibits Airway Eotaxin-1 Induction and Epithelial Apoptosis through Modulating Oxidative Stress-Responsive MAPK Signaling
Scientists elucidated that astragalin inhibited endotoxin-induced oxidative stress leading to eosinophilia and epithelial apoptosis in airways. [BMC Pulm Med] Full Article

LUNG CANCER

TLR7 Promotes Tumor Progression, Chemotherapy Resistance and Poor Clinical Outcomes in Non-Small Cell Lung Cancer
Scientists demonstrate that the injection of Toll-like receptor (TLR)7 agonist in NOD/SCID mice, in C57BL/6 wild-type and TLR7 deficient mice grafted with lung adenocarcinoma tumor cells leads to increased tumor progression and chemotherapeutic resistance. [Cancer Res] Abstract

Novel Multiarm Polyethylene Glycol-Dihydroartemisinin Conjugates Enhancing Therapeutic Efficacy in Non-Small-Cell Lung Cancer
Researchers investigated polyethylene glycol-dihydroartemisinin on chemical structure, hydrolysis, solubility, hemolysis, cell cytotoxicity in vitro, and efficacy in vivo. [Sci Rep] Full Article

Cannabinoids Increase Lung Cancer Cell Lysis by Lymphokine-Activated Killer Cells via Upregulation of ICAM-1
Using lung cancer cell lines and metastatic cells derived from a lung cancer patient, researchers addressed the impact of cannabinoid-induced intercellular adhesion molecule 1 (ICAM-1) on cancer cell adhesion to lymphokine-activated killer (LAK) cells and LAK cell-mediated cytotoxicity. [Biochem Pharmacol] Abstract

SIRT5 Facilitates Cancer Cell Growth and Drug Resistance in Non-Small Cell Lung Cancer
Researchers show that the mitochondrial class III NAD+-dependent deacetylase SIRT5 is overexpressed in human non-small cell lung cancer and high expression of SIRT5 predicts poor survival. SIRT5 knockdown represses lung cancer cell growth and transformation in vitro and in vivo. [Tumor Biol] Abstract

Cytotoxic Effects of Pyrrolidine Dithiocarbamate in Small-Cell Lung Cancer Cells, Alone and in Combination with Cisplatin
The cytocidal effect of pyrrolidine dithiocarbamate was investigated by focusing on cell viability, cell cycle arrest and apoptosis induction in small-cell lung cancer cell lines. [Int J Oncol] Abstract

Effect of Nitric Oxide Synthase on Multiple Drug Resistance Is Related to Wnt Signaling in Non-Small Cell Lung Cancer
Researchers detected the activation of Wnt/β-catenin signaling in nitric oxide synthase (iNOS)-induced drug-resistant lung cancer cells, and compared the effect of canonical and noncanonical Wnt pathway on the level of iNOS. [Oncol Rep] Abstract

Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
 
REVIEWS
Sonic Hedgehog Signaling in the Lung – From Development to Disease
The authors aim to fill the gap between the well-studied period of embryonic lung development and the adult diseased lung by reviewing the hedgehog pathway during the postnatal period and in adult uninjured and injured lungs. [Am J Respir Cell Mol Biol] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
INDUSTRY NEWS
AstraZeneca and Roche Announce Partnership to Develop Companion Diagnostic Test for AZD9291
AstraZeneca announced it has entered into collaboration with Roche to develop a plasma-based companion diagnostic test to support AZD9291, AstraZeneca’s investigational compound in clinical development for non-small-cell lung cancer. [AstraZeneca] Press Release

FDA Approves Striverdi Respimat to Treat Chronic Obstructive Pulmonary Disease
The U.S. Food and Drug Administration (FDA) approved Striverdi Respimat (olodaterol) inhalation spray to treat patients with chronic obstructive pulmonary disease, including chronic bronchitis and/or emphysema that are experiencing airflow obstruction. [U.S. Food and Drug Administration] Press Release

Incyte Announces Clinical Trial Agreement to Evaluate Combination of Two Novel Cancer Immunotherapies
Incyte Corporation announced that it has entered into a clinical trial agreement with Genentech to evaluate the safety, tolerability and preliminary efficacy of Incyte’s oral indoleamine dioxygenase-1 inhibitor, INCB24360, in combination with Genentech’s PD-L1 immune checkpoint inhibitor, MPDL3280A, in patients with non-small cell lung cancer. [Incyte Corporation] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW FAST: Functional Analysis & Screening Technologies Congress
November 17-19, 2014
Boston, United States

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Scientist – Transcriptional Networks in Lung Cancer (Cancer Research UK Manchester Institute)

NEW Postdoctoral Fellowship – Molecular Biology (Wayne State University)

Postdoctoral Researcher – Novel Therapeutic Targets and Molecular Mechanisms Associated with Resistance in NSCLC and SCLC (MD Anderson Cancer Center)

Postdoctoral Fellow – Mechanisms of Lung Alveoli Epithelial Repair (University of Illinois Chicago College of Medicine)

Postdoctoral Research Associate – Lung Development Research (Women and Infants Hospital of Rhode Island)

Postdoctoral Research Trainee – Lung Injury and Epithelial Repair (University of Tennessee Health Science Center)

Postdoctoral Scholar – Molecular Mechanisms of Lung Cancer, Lung Regeneration and Lung Development (University of California – San Francisco)

Primary Cell Culture Position – Heart/Lung Disease (Paramount Recruitment)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


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