Unique Volatolomic Signatures of TP53 and KRAS in Lung Cells
Volatile organic compounds are potential biomarkers for cancer detection in breath, but it is unclear if they reflect specific mutations. To test this, scientists compared human bronchial epithelial cell (HBEC) cell lines carrying the KRASV12 mutation, knockdown of TP53 or both with parental HBEC cells. [Br J Cancer] Abstract
Activation of Nrf2 Pathways Correlates with Resistance of NSCLC Cell Lines to CBP501 In Vitro
Researchers found that multiple nuclear factor erythroid-2 related factor2 (Nrf2) target genes showed high expression in CBP501-insensitive cell lines. Western blot and immunocytochemical analysis for Nrf2 in non-small cell lung cancer (NSCLC) cell lines also indicated higher protein level in CBP501 insensitive cell lines. [Mol Cancer Ther] Abstract
Genetic Susceptibility and Pulmonary Fibrosis
The inherited risk for pulmonary fibrosis is substantial, and recent data suggest that genetic risk for familial and sporadic forms of the disease are similar. Further characterizing this genetic risk will influence clinical practice in terms of categorization, diagnosis, and screening of individuals for this disease. [Curr Opin Pulm Med] Abstract
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INDUSTRY NEWS
Sorrento Awarded Grant from the National Institutes of Health for the Development of a Small Molecule Myc Inhibitor
Sorrento Therapeutics, Inc. announced that it has received non-dilutive funding for the preclinical development of a small molecule inhibitor targeting the important oncogenic transcription factor Myc. Abnormal Myc activity is believed to play a substantial role in at least one out of every seven cancer deaths and is often a key factor in breast, lung, colon, hematologic, and other cancers. [Sorrento Therapeutics, Inc.] Press Release
New Clinical Study Aims to Investigate the Genomics of Young Lung Cancer
The Addario Lung Cancer Medical Institute launched a new study, the Genomics of Young Lung Cancer, to understand why lung cancer occurs in young adults, who are athletic, never smokers and do not exhibit any of the known lung cancer genetic mutations. [The Bonnie J. Addario Lung Cancer Foundation] Press Release
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