Volume 3.28 | Jul 24

Pulmonary Cell News 3.28 July 24, 2014
Pulmonary Cell News
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Unique Volatolomic Signatures of TP53 and KRAS in Lung Cells
Volatile organic compounds are potential biomarkers for cancer detection in breath, but it is unclear if they reflect specific mutations. To test this, scientists compared human bronchial epithelial cell (HBEC) cell lines carrying the KRASV12 mutation, knockdown of TP53 or both with parental HBEC cells. [Br J Cancer] Abstract
Derivation of Metabolically Active Hepatocytes from Pluripotent Stem Cells - View On-Demand Webinar Now
PUBLICATIONS (Ranked by impact factor of the journal)
Interaction with Epithelial Cells Modifies Airway Macrophage Response to Ozone
Researchers developed an epithelial cell-macrophage (Mac) co-culture model to investigate how epithelial cell-derived signals affect Mac response to ozone. [Am J Respir Cell Mol Biol] Abstract

Respiratory Syncytial Virus Can Infect Basal Cells and Alter Human Airway Epithelial Differentiation
Using either mechanical or chemical injury models, scientists demonstrate a robust respiratory syncytial virus infection of p63+ basal cells in air-liquid interface cultures of human bronchial epithelial cells. [PLoS One]
Full Article

Mucin 1 (MUC1) Signaling Contributes to Increase the Resistance to Cell Death in Human Bronchial Epithelial Cells Exposed to Nickel Acetate
Since ErbBs are closely associated to MUC1, a glycoprotein component of airway mucus that is overexpressed in lung tumors, researchers investigated the role of this signaling system in the survival response of airway epithelial cells against nickel acetate-induced cell death. [Biometals] Abstract

Functional and Pharmacological Characterization of Volume-Regulated Anion Channels in Human Normal and Cystic Fibrosis Bronchial and Nasal Epithelial Cells
Scientists compared the biophysical features and pharmacological profiles of volume-regulated anion channels currents in healthy and cystic fibrosis respiratory epithelial cells in order to characterize these currents both functionally and pharmacologically. [Eur J Pharmacol] Abstract

Genotypically Defined β-Lactamase Negative Ampicillin Resistant Isolates of Non-Typeable Haemophilus influenzae Are Associated with Increased Invasion of Bronchial Epithelial Cells In Vitro
Scientists investigated the association between the presence of altered penicillin binding protein 3 in non-typeable H. influenzae and an increased capacity to invade bronchial epithelial cells in vitro. [J Med Microbiol] Abstract


Activation of Nrf2 Pathways Correlates with Resistance of NSCLC Cell Lines to CBP501 In Vitro
Researchers found that multiple nuclear factor erythroid-2 related factor2 (Nrf2) target genes showed high expression in CBP501-insensitive cell lines. Western blot and immunocytochemical analysis for Nrf2 in non-small cell lung cancer (NSCLC) cell lines also indicated higher protein level in CBP501 insensitive cell lines. [Mol Cancer Ther] Abstract

Effects of Lentivirus-Mediated RNAi Knockdown of NEDD9 on Human Lung Adenocarcinoma Cells In Vitro and In Vivo
Scientists investigated the biological behavior of lung adenocarcinoma A549 cells following transfection with NEDD9-specific lentiviral particles in vitro and in vivo. [Oncol Rep] Abstract

Immunomodulatory Effect of Melatonin in SK-LU-1 Human Lung Adenocarcinoma Cells Co-Cultured with Peripheral Blood Mononuclear Cells
Under co-culture conditions, increases in apoptotic cell death, increase in oxidative stress by reduction of glutathione and cell cycle arrest in G0/G1 in SK-LU-1 cells, were observed as the immunomodulatory effect of melatonin. [Cell Prolif] Abstract

Fibroblast Growth Factor-Inducible 14 Regulates Cell Growth and Multidrug Resistance of Small-Cell Lung Cancer through the Nuclear Factor-κB Pathway
Expression of fibroblast growth factor-inducible 14 (Fn14) was examined in 51 cases of small-cell lung cancer (SCLC) tissues by immunohistochemistry. Overexpression or knockdown of Fn14 was carried out in SCLC multidrug-resistant cell lines and the parental cell lines to assess its influence on cell growth and chemoresistance. [Anticancer Drugs] Abstract

Model the Human Respiratory Epithelium with PneumaCult™-ALI. Click to View Data
Genetic Susceptibility and Pulmonary Fibrosis
The inherited risk for pulmonary fibrosis is substantial, and recent data suggest that genetic risk for familial and sporadic forms of the disease are similar. Further characterizing this genetic risk will influence clinical practice in terms of categorization, diagnosis, and screening of individuals for this disease. [Curr Opin Pulm Med] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
Sorrento Awarded Grant from the National Institutes of Health for the Development of a Small Molecule Myc Inhibitor
Sorrento Therapeutics, Inc. announced that it has received non-dilutive funding for the preclinical development of a small molecule inhibitor targeting the important oncogenic transcription factor Myc. Abnormal Myc activity is believed to play a substantial role in at least one out of every seven cancer deaths and is often a key factor in breast, lung, colon, hematologic, and other cancers. [Sorrento Therapeutics, Inc.] Press Release

New Clinical Study Aims to Investigate the Genomics of Young Lung Cancer
The Addario Lung Cancer Medical Institute launched a new study, the Genomics of Young Lung Cancer, to understand why lung cancer occurs in young adults, who are athletic, never smokers and do not exhibit any of the known lung cancer genetic mutations. [The Bonnie J. Addario Lung Cancer Foundation]
Press Release

Pulmonary Fibrosis Foundation Disease Education Webinars Focus on Pulmonary Rehabilitation and the FDA’s Breakthrough Drug Therapy Designation
The Pulmonary Fibrosis Foundation announced two upcoming webinars, one of which is related to the U.S. Food and Drug Administration (FDA) granting breakthrough therapy designation for two new investigational treatments for idiopathic pulmonary fibrosis. [Pulmonary Fibrosis Foundation] Press Release

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European Medicines Agency (European Union)

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Therapeutic Goods Administration (Australia)
NEW Advances in Stem Cell Research 2014
September 16-17, 2014

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Postdoctoral Researcher – Novel Therapeutic Targets and Molecular Mechanisms Associated with Resistance in NSCLC and SCLC (MD Anderson Cancer Center)

Product Marketing Manager (Cesca Therapeutics)

Postdoctoral Fellow – Mechanisms of Lung Alveoli Epithelial Repair (University of Illinois Chicago College of Medicine)

Postdoctoral Research Associate – Lung Development Research (Women and Infants Hospital of Rhode Island)

Postdoctoral Research Trainee – Lung Injury and Epithelial Repair (University of Tennessee Health Science Center)

Postdoctoral Scholar – Molecular Mechanisms of Lung Cancer, Lung Regeneration and Lung Development (University of California – San Francisco)

Primary Cell Culture Position – Heart/Lung Disease (Paramount Recruitment)

Postdoctoral Position – Molecular and Cell Biology (Cornell University)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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