Volume 3.26 | Jul 10

Pulmonary Cell News 3.26 July 10, 2014
Pulmonary Cell News
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Ras Transformation Uncouples the Kinesin-Coordinated Cellular Nutrient Response
Scientists found that kinesin family member 2C (KIF2C) influences lysosomal organization in immortalized human bronchial epithelial cells. They tested the hypothesis that up-regulation of KIF2C and KIF2A by ERK1/2 caused aberrant lysosomal positioning and mechanistic target of rapamycin complex 1 activity in a mutant K-Ras-dependent cancer and cancer model. [Proc Natl Acad Sci USA] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Toxic Response of Graphene Nanoplatelets In Vivo and In Vitro
In an in vitro study using BEAS-2B cells, graphene nanoplatelets (GNPs) were located within autophagosome-like vacuoles 24 hours after exposure. The GNPs dose-dependently reduced cell viability, which was accompanied by an increase in the portion of cells in the subG1 and S phases. [Arch Toxicol] Abstract

Protein Kinase D Is Increased and Activated in Lung Epithelial Cells and Macrophages in Idiopathic Pulmonary Fibrosis
Researchers performed immunohistochemical analyses to assess the cell type-specific expression and activation of protein kinase D (PKD) family kinases in normal and idiopathic pulmonary fibrosis lung tissue sections. They also analyzed PKD activation and function in human lung epithelial cells. [PLoS One]
Full Article

MicroRNA-203 Accelerates Apoptosis in LPS-Stimulated Alveolar Epithelial Cells by Targeting PIK3CA
The functions of microRNAs in the development of acute lung injury were investigated to identify potential drug targets. MicroRNA-203 overexpression in A549 cells significantly promoted cell apoptosis by inducing S-phase cell-cycle arrest. [Biochem Biophys Res Commun] Abstract

Ac-SDKP Suppresses Epithelial-Mesenchymal Transition in A549 Cells via HSP27 Signaling
Researchers revealed that N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) exerts an anti-fibrotic effect on human type II alveolar epithelial cells, which are a source of myofibroblasts once exposed to TGF-β1, by decreasing the expression of heat shock protein 27 (HSP27). [Exp Mol Pathol] Abstract


FHIT Loss Confers Cisplatin Resistance in Lung Cancer via the AKT/NF-κB/Slug-Mediated PUMA Reduction
Inhibition concentration of 50% cell viability induced by cisplatin and soft agar growth and invasion capability were increased and decreased in fragile histidine triad (FHIT)-knockdown and -overexpressing cells, respectively. [Oncogene] Abstract

MicroRNA-128 Plays a Critical Role in Human Non-Small Cell Lung Cancer Tumorigenesis, Angiogenesis and Lymphangiogenesis by Directly Targeting Vascular Endothelial Growth Factor-C
Researchers show that the expression level of microRNA-128 was significantly downregulated in non-small cell lung cancer (NSCLC) tissues and cancer cells, and was significantly correlated with NSCLC differentiation, pathological stage and lymph node metastasis. [Eur J Cancer] Abstract

The Anoikis Effector Bit1 Displays Tumor Suppressive Function in Lung Cancer Cells
Researchers provide the first evidence of the tumor suppressive effect of Bit1 through a mechanism involving anoikis induction in human lung adenocarcinoma derived A549 cells. [PLoS One] Full Article

miR-143 Inhibits NSCLC Cell Growth and Metastasis by Targeting Limk1
Overexpression of microRNA (miR)-143 suppressed non-small cell lung cancer (NSCLC) cell proliferation, induced apoptosis, and inhibited migration and invasion in vitro. [Int J Mol Sci]
Abstract | Download Full Article

T-Type Ca2+ Channel Blocker, KYS05090 Induces Autophagy and Apoptosis in A549 Cells through Inhibiting Glucose Uptake
KYS05090 induced autophagy- and apoptosis-mediated cell death in human lung adenocarcinoma A549 cells. Although KYS05090 decreased intracellular Ca2+ levels, it was not directly related with KYS05090-induced cell death. [Molecules] Abstract | Download Full Article

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Beyond Chemotherapy and Targeted Therapy: Adoptive Cellular Therapy in Non-Small Cell Lung Cancer
The authors review recent advances in adoptive cellular therapy (ACT) for non-small cell lung cancer (NSCLC) in clinical trials and provide a perspective on the improvement in ACT and potential therapeutic approaches using engineered T cell therapy for NSCLC. [Mol Biol Rep] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
LUNGevity Foundation, Lung Cancer Research Foundation, and Melanoma Research Alliance Join Forces in First-Ever Research Collaboration
LUNGevity Foundation announced a partnership with the Lung Cancer Research Foundation and Melanoma Research Alliance to co-fund new, innovative research on PD-1 inhibitor treatment options for both non-small cell lung cancer and metastatic melanoma patients with brain metastases. [LUNGevity Foundation]
Press Release

Zeynep Gumus, Abhijit Patel, and Kimberly Rieger-Christ Receive LUNGevity Foundation 2014 Early Detection Awards for Lung Cancer Research
LUNGevity Foundation announced the 2014 recipients of its Early Detection Award for Translational Lung Cancer Research. Each of the three multi-year early detection awards ranges from $100,000 to $250,000 for the first year and is renewable in that amount, based on research progress, for each subsequent year. [LUNGevity Foundation] Press Release

DelMar Pharmaceuticals Receives Funding from the Canadian Federal Government
DelMar Pharmaceuticals, Inc. announced that the company has been awarded a non-refundable financial contribution of up to CDN$194,000 from the National Research Council of Canada’s Industrial Research Assistance Program. [DelMar Pharmaceuticals, Inc.] Press Release

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Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Postdoctoral Fellow – Mechanisms of Lung Alveoli Epithelial Repair (University of Illinois Chicago College of Medicine)

Postdoctoral Fellow – Lung and Vascular Disease (University of Illinois)

Postdoctoral Research Associate – Lung Development Research (Women and Infants Hospital of Rhode Island)

Postdoctoral Research Trainee – Lung Injury and Epithelial Repair (University of Tennessee Health Science Center)

Director, US Medical Affairs – Lung Job (Celgene Corporation)

Postdoctoral Scholar – Molecular Mechanisms of Lung Cancer, Lung Regeneration and Lung Development (University of California – San Francisco)

Primary Cell Culture Position – Heart/Lung Disease (Paramount Recruitment)

Postdoctoral Position – Molecular and Cell Biology (Cornell University)

Junior Research Group Leader Position – Cell-Derived Therapeutics in Chronic Lung Disease (Helmholtz Zentrum München)

Postdoctoral Fellow – Lung Biology and Genomics (Harvard University)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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