Volume 3.24 | Jun 26

Pulmonary Cell News 3.24 June 26, 2014
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
UCLA Scientists Identify Link between Stem Cell Regulation and the Development of Lung Cancer
University of California, Los Angeles (UCLA) researchers discovered the inner workings of the process thought to be the first stage in the development of lung cancer. Their study explains how factors that regulate the growth of adult stem cells that repair tissue in the lungs can lead to the formation of precancerous lesions. [Press release from UCLA discussing online prepublication in Cell Stem Cell] Press Release | Abstract | Graphical Abstract
Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
 
PUBLICATIONS (Ranked by impact factor of the journal)
Behavioral Heterogeneity of Adult Mouse Lung Epithelial Progenitor Cells
Investigators introduce a method of airway micro-dissection which enabled them to study the progenitor behavior of pulmonary epithelial cells in region-specific contexts. [Stem Cells Dev] Abstract

Chronic Alcohol Ingestion in Rats Alters Lung Metabolism, Promotes Lipid Accumulation, and Impairs Alveolar Macrophage Functions
Scientists studied the metabolic consequences of chronic alcohol consumption in rat lungs in vivo and in alveolar epithelial type II cells and alveolar macrophages in vitro. [Am J Respir Cell Mol Biol] Abstract

Cell Stress Induces Upregulation of Osteopontin via the ERK Pathway in Type II Alveolar Epithelial Cells
Investigators demonstrate the molecular mechanism of osteopontin (OPN) induction in type II alveolar epithelial cells (AEC II) and elucidate the functions of OPN in AEC II and lung fibroblasts. [PLoS One] Full Article

Accumulation of Metals in GOLD4 COPD Lungs is Associated with Decreased CFTR Levels
The effect of cigarette smoke on down-regulation of cystic fibrosis transmembrane conductance regulator (CRTR) expression and function was assessed by researchers using primary human airway epithelial cells. [Respir Res] Abstract | Full Article

LUNG CANCER

IL-1β-Mediated Repression of MicroRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis
Scientists report that the pro-inflammatory cytokine IL-1β is dramatically elevated in the serum of patients with non-small cell lung cancer. [Cancer Res] Abstract

IL-6 Enriched Lung Cancer Stem-Like Cell Population by Inhibition of Cell Cycle Regulators via DNMT1 Up-Regulation
Researchers demonstrate that IL-6 enriches the properties of lung cancer stem-like cells in A549 lung cancer cells cultured in spheroid medium. IL-6 also promotes sphere formation and stem-like properties of A549 cells by enhancing cell proliferation. [Int J Cancer] Abstract

KPT-330 Has Antitumor Activity against Non-Small Cell Lung Cancer
Scientists investigated the biologic and pharmacologic activities of a chromosome region maintenance 1 inhibitor against human non-small cell lung cancer cells both in vitro and in vivo. [Brit J Cancer] Abstract

Cooperation of Tyrosine Kinase Receptor and Epidermal Growth Factor Receptor Signaling Enhances Migration and Dispersal of Lung Tumor Cells
Based on recent reports that tyrosine kinase receptor (TrkB) can also be transactivated through epidermal growth-factor receptor signaling and thus regulates migration of early neurons, scientists investigated the role of TrkB in migration of lung tumor cells. [PLoS One] Full Article

Video Protocol: Mucociliary Differentiation of Primary Bronchial Epithelial Cells
 
REVIEWS
Clinical Potentials of Human Pluripotent Stem Cells in Lung Diseases
The authors provide an overview of recent advances in research on pluripotent stem cells in lung tissue regeneration and discuss technical challenges that must be overcome for their clinical applications in the future. [Clin Transl Med] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
INDUSTRY NEWS
Two 24-Week Phase III Studies of Lumacaftor in Combination with Ivacaftor Met Primary Endpoint with Statistically Significant Improvements in Lung Function in People with Cystic Fibrosis Who Have Two Copies of the F508del Mutation
Vertex Pharmaceuticals Incorporated announced results from two Phase III studies of Lumacaftor in combination with Ivacaftor that showed statistically significant improvements in lung function in people ages 12 and older with cystic fibrosis who have two copies of the F508del mutation in the cystic fibrosis transmembrane conductance regulator gene. [Vertex Pharmaceuticals Inc.] Press Release

New Immuno-Oncology Lung Cancer Collaboration Launched with Dana-Farber’s Belfer Institute; One of Seven New Strategic Oncology Partnerships
Johnson & Johnson Innovation announced a three-year collaboration with the Dana-Faber Cancer Institute’s Belfer Institute for Applied Cancer Science to determine which lung cancer patients are most likely to benefit from a new generation of immuno-oncology therapies. [Johnson & Johnson Innovation LLC] Press Release

From our sponsor: Free human hematopoietic progenitors wallchart. Request your copy.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 2014 Case Western Reserve Cancer Stem Cell Conference
August 17-20, 2014
Cleveland, United States

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Associate – Lung Development Research (Women and Infants Hospital of Rhode Island)

NEW Postdoctoral Research Trainee – Lung Injury and Epithelial Repair (University of Tennessee Health Science Center)

NEW Director, US Medical Affairs – Lung Job (Celgene Corporation)

Postdoctoral Scholar – Molecular Mechanisms of Lung Cancer, Lung Regeneration and Lung Development (University of California – San Francisco)

Primary Cell Culture Position – Heart/Lung Disease (Paramount Recruitment)

Postdoctoral Fellow – Lung Cancer Biomarker Discovery and Applications (Shantou University)

Postdoctoral Position – Molecular and Cell Biology (Cornell University)

Junior Research Group Leader Position – Cell-Derived Therapeutics in Chronic Lung Disease (Helmholtz Zentrum München)

Postdoctoral Fellow – Lung Biology and Genomics (Harvard University)

Postdoctoral Fellowship – Malignant Progression of Lung Cancer (MD Anderson Cancer Center)

Research Fellow – Pulmonary Cancer (Mayo Clinic – Rochester)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


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