|PUBLICATIONS (Ranked by impact factor of the journal)|
Wnt3a Mitigates Acute Lung Injury by Reducing P2X7 Receptor-Mediated Alveolar Epithelial Type I Cell Death|
Scientists hypothesized that P2X7 receptor-mediated purinergic signaling and its interaction with Wnt/β-catenin signaling contributes to alveolar epithelial type I cell death. [Cell Death Dis]
Oncostatin M Overexpression Induces Matrix Deposition, STAT3 Activation, and SMAD1 Dysregulation in Lungs of Fibrosis-Resistant BALB/c Mice
Gp130 cytokines including IL-6, LIF, CT-1, but not IL-31, induced STAT3 activation and SMAD1/5/8 signaling suppression in C10 mouse lung epithelial cells and BEAS 2B bronchial epithelial cells, and researchers found that pharmacological inhibition of STAT3 activation reversed oncostatin M-induced SMAD1/5/8 signaling suppression in vitro. [Lab Invest]
Effect of P2X7 Receptor Knockout on AQP-5 Expression of Type I Alveolar Epithelial Cells
To elucidate the role of the P2X7 receptor in alveolar epithelial type I cells scientists characterized the pulmonary phenotype of P2X7 receptor knockout mice by using immunohistochemistry, western blot analysis and real-time RT PCR. [PLoS One]
Der p 2 Promotes Motility of Airway Epithelial Cell Attributing to AKT/GSK3β-Associated Epithelial-to-Mesenchymal Transition
Using human bronchial cell BEAS-2B as cell model incorporating with immunoblotting and real-time quantitative PCR, scientists reveal that der p 2 significantly diminished epithelial marker E-cadherin and elevated mesenchymal marker vimentin and alpha-smooth muscle actin in both protein and mRNA levels. [Mol Cell Biochem]
TMEPAI Inhibits TGF-β Signaling by Promoting Lysosome Degradation of TGF-β Receptor and Contributes to Lung Cancer Development
Depletion of transmembrane prostate androgen-induced protein (TMEPAI) in A549 lung cancer cells inhibits cell proliferation, migration and invasion, while TMEPAI expression in nude mice promotes tumorigenesis. [Cell Signal]
TC-1 Overexpression Promotes Cell Proliferation in Human Non-Small Cell Lung Cancer that Can Be Inhibited by PD173074
Researchers found that thyroid cancer-1 (TC-1) is highly expressed in non-small cell lung cancer (NSCLC) and that its aberrant expression is strongly associated with NSCLC cell proliferation. [PLoS One]
Antitumor Activity of Selective MEK1/2 Inhibitor AZD6244 in Combination with PI3K/mTOR Inhibitor BEZ235 in Gefitinib-Resistant NSCLC Xenograft Models
Researchers evaluated the therapeutic efficacy of AZD6244 alone or with BEZ235, an orally available potent inhibitor of phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR), in gefitinib-resistant non-small cell lung carcinoma (NSCLC) models. [J Exp Clin Cancer Res]
Growth-Inhibiting and Apoptosis-Inducing Activities of Myricanol from the Bark of Myrica rubra in Human Lung Adenocarcinoma A549 Cells
Scientists investigated whether or not Myricanol extracted from Myrica rubra bark elicits anti-cancer effects on human lung adenocarcinoma A549 cells by inducing apoptosis in vivo. [Phytomedicine]
Heading to ISSCR 2014 in Vancouver?
Come Visit Connexon Creative at Booth #507 and Enter to Win $100 Amazon Gift Card!
Have we missed an important article or publication in Pulmonary Cell News? Click here to submit!
Comments or Suggestions? Submit your feedback here.