Volume 3.22 | Jun 12

Pulmonary Cell News 3.22 June 12, 2014
Pulmonary Cell News
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Resistance to Lung Cancer Targeted Therapy Can Be Reversed, Study Suggests
Up to 40 percent of lung cancer patients do not respond to a targeted therapy designed to block tumor growth – a puzzling clinical setback that researchers have long tried to solve. Now, scientists have discovered why that intrinsic resistance occurs – and they have pinpointed a drug they say could potentially reverse it. [Press release from Georgetown University Medical Center discussing online prepublication in the Journal of Clinical Investigation] Press Release | Full Article
Video Protocol: Mucociliary Differentiation of Primary Bronchial Epithelial Cells
PUBLICATIONS (Ranked by impact factor of the journal)
Inflammasome Activation in Airway Epithelial Cells after Multi-Walled Carbon Nanotube Exposure Mediates a Profibrotic Response in Lung Fibroblasts
Scientists investigated the mechanism of multi-walled carbon nanotubes (MWCNT)-induced primary human bronchial epithelial (HBE) cell injury and its contribution in inducing a profibrotic response. MWCNT induced NLRP3 inflammasome dependent pyroptosis in HBE cells in a time- and dose-dependent manner. [Part Fibre Toxicol] Abstract | Full Article

Role of Klotho, an Antiaging Protein, in Pulmonary Fibrosis
Researchers defined the role of Klotho in pulmonary fibrosis using a murine model of ovalbumin-induced chronic asthma and in BEAS-2B human bronchial epithelial cells. [Arch Toxicol] Abstract

Exosomal miR-21 Derived from Arsenite-Transformed Human Bronchial Epithelial Cells Promotes Cell Proliferation Associated with Arsenite Carcinogenesis
Scientists aimed to determine whether miRNAs secreted from human bronchial epithelial (HBE) cells transformed by 1.0 μM arsenite are transferred into normal HBE cells and are functionally active in the recipient cells. [Arch Toxicol] Abstract

Role of Anion Exchangers in Cl and HCO3 Secretion by the Human Airway Epithelial Cell Line Calu-3
Researchers assessed the contribution of apical and basolateral Cl/HCO3 exchangers to Cl and HCO3 transport in the Calu-3 cell derived from human airway submucosal glands. [Am J Physiol Cell Physiol] Abstract

Calcium Signaling and β2-Adrenergic Receptors Regulate 1-Nitropyrene Induced CXCL8 Responses in BEAS-2B Cells
Scientists investigated the mechanisms of CXCL8 responses induced by 1-nitropyrene in human bronchial epithelial BEAS-2B cells, with focus on the possible importance of Ca2+-signaling and activation of β2-adrenergic receptors. [Toxicol In Vitro] Abstract

Agonist-Induced β2-Adrenoceptor Desensitization and Downregulation Enhance Pro-Inflammatory Cytokine Release in Human Bronchial Epithelial Cells
Researchers investigated the cross-talk between β-adrenoceptor (β-AR) agonist-mediated effects on β2-AR function and expression and cytokine release in human bronchial epithelial cells. [Pulm Pharmacol Ther] Abstract

Role of SIRT1 in Streptococcus pneumoniae-Induced Human β-Defensin-2 and Interleukin-8 Expression in A549 Cell
Researchers examined the role of sirtuin 1 (SIRT1) in mediating S. pneumoniae-induced human β-defensin-2 and interleukin-8 expression in the alveolar epithelial cell line A549 and the underlying mechanisms involved. [Mol Cell Biochem] Abstract


Essential Role of Aldehyde Dehydrogenase 1A3 (ALDH1A3) for the Maintenance of Non-Small Cell Lung Cancer Stem Cells Is Associated with the STAT3 Pathway
Lung cancer stem cells (CSCs) with elevated aldehyde dehydrogenase (ALDH) activity are self-renewing, clonogenic and tumorigenic. A genome-wide gene expression analysis was performed to identify genes differentially expressed in the ALDH+ vs. ALDH- cells. To explore the function in CSCs scientists manipulated their expression followed by colony and tumor formation assays. [Clin Cancer Res] Abstract

Metadherin Regulates Proliferation and Metastasis via Actin Cytoskeletal Remodeling in Non-Small Cell Lung Cancer
The role of metaderin (MTDH) in cancer cell proliferation, migration and invasion was studied by modulation of MTDH expression in NSCLC cell lines. These functions of MTDH were further confirmed in vivo. [Br J Cancer] Abstract

Altered β1,6-GlcNAc Branched N-Glycans Impair TGF-β-Mediated Epithelial-to-Mesenchymal Transition through Smad Signaling Pathway in Human Lung Cancer
Researchers studied the association of N-acetylglucosaminy transferase V (GnT-V) expression with lung cancer epithelial-to-mesenchymal transition (EMT) behavior. They found that GnT-V expression was correlated with epithelial marker positively and mesenchymal marker negatively. GnT-V levels, as well as β1,6-GlcNAc branched N-glycans, were strongly reduced in TGF-β1-induced EMT of human lung adenocarcinoma A549 cells. [J Cell Mol Med] Full Article

Secretory Phospholipase A2-IIa Upregulates HER/HER2-Elicited Signaling in Lung Cancer Cells
Researchers showed that elevated HER/HER2-PI3K-Akt-NF-κB signaling contributes to secretory phospholipase A2 group IIa (sPLA2-IIa) overexpression in lung cancer cells. sPLA2-IIa in turn phosphorylates and activates HER2 and HER3 in a time- and dose-dependent manner in lung cancer cells. [Int J Oncol]
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The Cell Biology of Asthma
The clinical manifestations of asthma are caused by obstruction of the conducting airways of the lung. Complementary experimental approaches involving cultured cells, animal models, and human clinical studies have provided many insights into diverse mechanisms that contribute to airway epithelial and smooth muscle cell pathology in this complex disease. [J Cell Biol] Full Article

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
GSK and Theravance Announce Positive Data from Two Studies Evaluating the Efficacy and Safety of Incruse™ Ellipta® when Added to Relvar®/Breo® Ellipta® in Patients with COPD
GlaxoSmithKline plc and Theravance, Inc. announced positive results from two Phase III studies, which showed that patients with chronic obstructive pulmonary disease (COPD) who received the anticholinergic, Incruse™ Ellipta®, or umeclidinium 125µg in addition to Relvar®/Breo® Ellipta® (fluticasone furoate/vilanterol, “FF/VI”), an inhaled corticosteroid / long-acting beta2-agonist combination, achieved an additional improvement in lung function compared to patients receiving FF/VI plus placebo. [Theravance, Inc.] Press Release

Proof-of-Concept Study of Ivacaftor Monotherapy Showed Improvements in Lung Function after Two Weeks of Treatment in People with Cystic Fibrosis Who Have a Residual Function Mutation
Vertex Pharmaceuticals Incorporated announced the results of a two-part proof-of-concept study of ivacaftor in 24 people with cystic fibrosis who have a residual function mutation. In the study, ivacaftor was generally well-tolerated, and the most common adverse events in the treatment group were cough and respiratory tract infection. [Vertex Pharmaceuticals Incorporated] Press Release

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AstraZeneca In-Licenses Synairgen’s SNG001 as a Novel Immuno-Modulatory Therapy for Viral-Induced Exacerbation in Asthma
AstraZeneca announced a global license agreement with Synairgen Plc for SNG001, a novel, inhaled interferon beta in clinical development for treating respiratory tract viral infections in patients with severe asthma. [AstraZeneca] Press Release

The Pulmonary Fibrosis Foundation Receives Grant from Biogen Idec to Support the PFF Patient Registry
The Pulmonary Fibrosis Foundation (PFF) announced a key partnership with Biogen Idec in support of the PFF Patient Registry. The PFF announced its plan to establish a PFF Patient Registry, along with a PFF Care Center Network. Once established, the PFF Patient Registry will become the largest collection of pulmonary fibrosis patient data in the world. [The Pulmonary Fibrosis Foundation] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 2014 Best of American Society of Clinical Oncology (ASCO) Chicago Meeting
August 15-16, 2014
Chicago, United States

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Primary Cell Culture Position – Heart/Lung Disease (Paramount Recruitment)

Postdoctoral Fellow – Lung Cancer Biomarker Discovery and Applications (Shantou University)

Postdoctoral Position – Molecular and Cell Biology (Cornell University)

PhD Position – Role of Long Non-Coding RNAs in the Lung and During Activation of Lung Fibroblasts (University of Bath)

Junior Research Group Leader Position – Cell-Derived Therapeutics in Chronic Lung Disease (Helmholtz Zentrum München)

Postdoctoral Fellow – Lung Biology and Genomics (Harvard University)

Postdoctoral Fellowship – Malignant Progression of Lung Cancer (MD Anderson Cancer Center)

Research Fellow – Pulmonary Cancer (Mayo Clinic – Rochester)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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