Pulmonary Cell News

Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.

YTHDF1-CLOCK Axis Contributes to Pathogenesis of Allergic Airway Inflammation through LLPS

[Cell Reports] Scientists reported that YTHDF1 was highly expressed in allergic airway epithelial cells and asthmatic patients and that it influenced proinflammatory responses.

Mast Cell Activation Disrupts Interactions Between Endothelial Cells and Pericytes During Early Life Allergic Asthma

[Journal Of Clinical Investigation] Using quantitative imaging in precision-cut lung slices, scientists reported that exposure of neonatal mice to house dust mite extract disrupted endothelial cell/pericyte interactions in adventitial areas.

Targeted Therapies Prime Oncogene-Driven Lung Cancers for Macrophage-Mediated Destruction

[Journal Of Clinical Investigation] Researchers developed a novel screening platform to identify drugs that rendered lung cancer cells more vulnerable to macrophage attack, and identified therapeutic synergy existed between genotype-directed therapies and anti-CD47 antibodies.

Ubiquitin Ligase Subunit FBXO9 Inhibits V-ATPase Assembly and Impedes Lung Cancer Metastasis

[Experimental Hematology & Oncology] Lentiviral vectors carrying miRNA-based shRNA sequences for gene-specific knockdown were generated, and Lenti-CRISPR-Cas9 vectors containing gene-specific sgRNA sequences were designed.

FAM83B Regulates Mitochondrial Metabolism and Anti-Apoptotic Activity in Pulmonary Adenocarcinoma

[Apoptosis] Multiple assays, such as CCK8, wound healing, EdU, and transwell assays, were employed to confirm the augmented chemotherapy resistance, heightened cell proliferation, migration, and invasion caused by FAM83B overexpression in lung adenocarcinoma cells.

LCRF Announces Grant Awards for ADC Research

[Lung Cancer Research Foundation] The Lung Cancer Research Foundation (LCRF) has announced three research grant awards focused on the further understanding of the mechanism of action of antibody drug conjugates (ADCs) and exploring the use of ADCs in lung cancer types beyond NSCLC.

Endoplasmic Reticulum Stress Enhances the Expression of TLR3-Induced TSLP by Airway Epithelium

[American Journal Of Physiology-Lung Cellular And Molecular Physiology] Researchers determined if endoplasmic reticulum stress and the unfolded protein response signaling are involved in thymic stromal lymphopoietin induction in the airway epithelium.

Functional Roles of CD26/DPP4 in Lipopolysaccharide-Induced Lung Injury

[American Journal Of Physiology-Lung Cellular And Molecular Physiology] Investigators characterized the functional role of CD26/Dipeptidyl peptidase-4 (DPP4) expression in lipopolysaccharide-induced lung injury in mice, isolated alveolar macrophages, and cultured lung endothelial cells.

Phosphorylated SHMT2 Regulates Oncogenesis through m6A Modification in Lung Adenocarcinoma

[Advanced Biology] The authors clarified that mitogen-activated protein kinase 1-mediated phosphorylation at Ser90 was the key mechanism underlying serine hydroxymethyltransferase 2 (SHMT2) upregulation in lung adenocarcinoma.

IL-13 Facilitates Ferroptotic Death in Asthmatic Epithelial Cells via SOCS1-Mediated Ubiquitinated Degradation of SLC7A11

[Redox Biology] Investigators demonstrated that the serum level of malondialdehyde, an index of lipid peroxidation, positively correlated with IL-13 level and negatively correlated with the predicted forced expiratory volume in one second in asthmatics.

The Emerging Role of Extracellular Vesicles in Bronchopulmonary Dysplasia

[American Journal Of Physiology-Lung Cellular And Molecular Physiology] The authors explore some of the recent advances in this field and the evolving knowledge of the role of extracellular vesicles in bronchopulmonary dysplasia.

Clobetasol Propionate, a Nrf-2 Inhibitor, Sensitizes Human Lung Cancer Cells to Radiation-Induced Killing via Mitochondrial ROS-Dependent Ferroptosis

[Acta Pharmacologica Sinica] The radiosensitizing efficacy of a synthetic glucocorticoid clobetasol propionate in A549 human lung cancer cells was evaluated.

Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

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