Volume 3.10 | Mar 20

Pulmonary Cell News 3.10 March 20, 2014
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Aqueous Cationic, Anionic and Non-Ionic Multi-Walled Carbon Nanotubes, Functionalized with Minimal Framework Damage, for Biomedical Application
Grafted multi-walled carbon nanotubes exhibited relatively low bioreactivity on transformed human alveolar epithelial type 1-like cells following 24 hour exposure as demonstrated by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium and lactate dehydrogenase release assays. [Biomaterials] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Glucocorticoids Induce the Production of the Chemoattractant CCL20 in Airway Epithelium
Researchers studied CCL20 and CXCL8 sputum levels in asthmatic subjects using inhaled glucocorticoids or not, and the effect of budesonide on CCL20 and CXCL8 production in primary bronchial epithelial cells. [Eur Respir J] Abstract

Long Noncoding RNA Are Aberrantly Expressed In Vivo in the Cystic Fibrosis Bronchial Epithelium
Scientists examined the expression profile of long non-coding RNAs (lncRNAs), in the airway epithelium of people with cystic fibrosis (CF). They examined the expression of 30,586 lncRNAs by microarray, in vivo in bronchial cells isolated from endobronchial brushings obtained from CF and non-CF individuals. [Int J Biochem Cell Biol] Abstract

Short-Term Cigarette Smoke Exposure Leads to Metabolic Alterations in Lung Alveolar Cells
Scientists examined the effect of cigarette smoke exposure on metabolism in alveolar type II cells. Palmitate utilization was accompanied by an increase in the expression of CD36 and carnitine-palmitoyl transferase 1 in type II alveolar cells, for the transport of palmitate into the cells and into mitochondria, respectively. [Am J Respir Cell Mol Biol] Abstract

Identification of an Outer Membrane Lipoprotein Involved in Nasopharyngeal Colonization by Moraxella catarrhalis in an Animal Model
Colonization of the human nasopharynx by Moraxella catarrhalis is presumed to involve attachment of this bacterium to the mucosa. DNA microarray analysis was used to determine whether attachment of M. catarrhalis to human bronchial epithelial cells in vitro affected gene expression in this bacterium. [Infect Immun] Abstract

LUNG CANCER

PCK2 Activation Mediates an Adaptive Response to Glucose Depletion in Lung Cancer
Researchers showed that the mitochondrial isoform of phosphoenolpyruvate carboxykinase (PCK2) is expressed and active in three lung cancer cell lines and in non-small cell lung cancer samples. [Oncogene] Abstract

GSK3ß Overexpression Indicates Poor Prognosis and Its Inhibition Reduces Cell Proliferation and Survival of Non-Small Cell Lung Cancer Cells
Researchers investigated the influence of glycogen synthase kinase 3 beta (GSK3ß) expression on the prognosis of human non-small cell lung cancer (NSCLC) and the effects of GSK3ß inhibition in NSCLC cell lines. [PLoS One] Full Article

Cantharidin Induces DNA Damage and Inhibits DNA Repair-Associated Protein Levels in NCI-H460 Human Lung Cancer Cells
Researchers determined whether cantharidin induced DNA damage and condensation and altered levels of proteins in NCI-H460 cells in vitro. [Environ Toxicol] Abstract

Autocrine Signaling via Release of ATP and Activation of P2X7 Receptor Influences Motile Activity of Human Lung Cancer Cells
Investigators showed that autocrine signaling through release of ATP and activation of P2X7 receptor influences migration of human lung cancer cells. [Purinergic Signal] Abstract

The Tumor-Suppressing Activity of the Prenyl Diphosphate Synthase Subunit 2 Gene in Lung Cancer Cells
Scientists investigated the tumor-suppressing activity of prenyl diphosphate synthase subunit 2 (PDSS2) in lung cancer cells using cellular and molecular tools. The PDSS2 gene has low levels of expression in human lung cancer cell lines. [Anticancer Drugs] Abstract

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REVIEWS
New Strategies in Lung Cancer: Epigenetic Therapy for Non-Small-Cell Lung Cancer
The authors review the current status of attempts to target the epigenome, heritable modifications of DNA, histones and chromatin that may act to modulate gene expression independently of DNA coding alterations, in non-small-cell lung cancer and the potential for combinatorial and sequential treatment strategies. [Clin Cancer Res] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
INDUSTRY NEWS
GSK’s MAGE-A3 Cancer Immunotherapeutic Phase III Study in Non-Small Cell Lung Cancer Misses First Co-Primary Endpoints
Agenus Inc. announced that GlaxoSmithKline’s (GSK’s) MAGRIT study, a Phase III randomized, blinded, placebo-controlled MAGE-A3 cancer immunotherapeutic trial in non-small cell lung cancer patients, which contains Agenus’QS-21 Stimulon® adjuvant, did not meet its first or second co-primary endpoint. [Agenus Inc.]
Press Release

VaxInnate Begins Phase I Clinical Trial to Evaluate Quadrivalent Vaccine for Prevention of Seasonal Flu
VaxInnate Corporation announced that enrollment has commenced in a Phase I clinical trial to evaluate VAX2012Q, a recombinant quadrivalent vaccine in development for the prevention of seasonal influenza. [VaxInnate Corporation] Press Release

Ohio State Partners with MedVax Technologies, Inc. to Bring a Cancer Peptide Vaccine to Patients
The Ohio State University, through the Ohio State Innovation Foundation, has signed an exclusive world-wide licensing agreement with MedVax Technologies, Inc., for the licensing of groundbreaking cancer peptide vaccine technologies. The anticancer vaccine technologies are designed for the treatment and prevention of cancers associated with the HER2 protein. [The Ohio State University] Press Release

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POLICY NEWS
Alliance for Regenerative Medicine Announces Introduction of Regenerative Medicine Promotion Act of 2014 in the Senate
The Alliance for Regenerative Medicine announced the introduction of the Regenerative Medicine Promotion Act of 2014 in the U.S. Senate and expressed appreciation for the efforts of its lead sponsors, Senators Barbara Boxer and Mark Kirk. [Alliance for Regenerative Medicine] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Anti-Cancer Therapeutics: From Research to Trials to Treatment
May 14, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Research Project Leader – Next Generation Lung Cancer Diagnostics (BIOBASE)

Postdoctoral Scholar – Mechanisms of Pathologic Mucus Gel Formation in Diseases of the Lung (University of California, San Francisco)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Postdoctoral Position – Pulmonary Research (Cedars-Sinai Medical Center)

Junior Research Group Leader – Stem Cell Based Therapies for Lung Diseases (Hannover Medical School)

Postdoctoral Scientist – Small Cell Lung Cancer Circulating Tumor Cell Derived Explant Tumor Models (Cancer Research UK Manchester Institute)

Postdoctoral Position – Novel Therapeutic Approaches to the Treatment of Lung Cancer (Sloan Kettering Institute)

PhD Studentships in Pulmonary Medicine (University of Giessen and Marburg Lung Center)

Postdoctoral Scholar – Molecular Mechanisms of Lung Cancer, Lung Regeneration and Lung Development (UCSF)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)


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