Reduced NF1 Expression Confers Resistance to EGFR Inhibition in Lung Cancer
Through a genome-wide siRNA screen in a human lung cancer cell line and analyses of murine mutant epidermal growth factor receptor (EGFR)-driven lung adenocarcinomas, investigators found that erlotinib resistance was associated with reduced expression of neurofibromin, the RAS GTPase activating protein encoded by the neurofibromatosis type 1 (NF1) gene. [Cancer Discov]
Biomarkers in Chronic Obstructive Pulmonary Disease: Confusing or Useful?
The field of biomarker research has almost reached unmanageable proportions in chronic obstructive pulmonary disease. The knowledge emerging provides an enormous potential for understanding the disease pathophysiology, for developing markers specific for long-term outcomes, and for developing new therapeutic strategies. [Int J Chron Obstruct Pulmon Dis]
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AAAS Launches Open-Access Journal
Joining a herd of other scientific societies, AAAS (American Association for the Advancement of Science) announced that it will launch the organization’s first online, fully open-access journal early next year. The new journal, called Science Advances, will give authors another outlet for papers that they are willing to pay to make immediately free to the public. [ScienceInsider]