Volume 3.02 | Jan 23

Pulmonary Cell News 3.02 January 23, 2014
Pulmonary Cell News
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Miro1 Regulates Intercellular Mitochondrial Transport and Enhances Mesenchymal Stem Cell Rescue Efficacy
Researchers demonstrated that overexpression of Miro1 in mesenchymal stem cells (MSC) (MSCmiroHi) leads to enhanced mitochondrial transfer and rescue of epithelial injury, while Miro1 knockdown (MSCmiroLo) leads to loss of efficacy. Treatment with MSCmiroHi was associated with greater therapeutic efficacy, when compared to control MSC, in mouse models of rotenone induced airway injury and allergic airway inflammation. [EMBO J]
Full Article | Press Release | Graphical Abstract | Video
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PUBLICATIONS (Ranked by impact factor of the journal)
Combined Inhaled Salbutamol and Mannitol Therapy for Mucus Hyper-Secretion in Pulmonary Diseases
Researchers focused on the co-engineering of salbutamol sulphate, a common bronchodilator, and mannitol, a mucolytic, as a potential combination therapy for mucus hypersecretion. [AAPS J] Abstract

Protective Effects of KGF-2 on Ischemia/Reperfusion-Induced Lung Injury in Rats
Researchers investigated the potential effects of keratinocyte growth factor-2 (KGF-2) on ischemia/reperfusion-induced lung injury in rats and the related mechanisms. [Am J Respir Cell Mol Biol] Abstract

Nuclear Localization of VEGF-D and Regulation of c-Myc-Dependent Transcripts in Human Lung Fibroblasts
Investigators report that, independent of its cell surface receptors, full-length vascular endothelial growth factor-D (VEGF-D) accumulated in nuclei of fibroblasts and that this process appears to increase with cell density. [Am J Respir Cell Mol Biol] Abstract

TNF-α Induces Cytosolic Phospholipase A2 Expression via Jak2/PDGFR-Dependent Elk-1/p300 Activation in Human Lung Epithelial Cells
Researchers demonstrated that tumor necrosis factor-α (TNF-α) induced cytosolic phospholipase A2 (cPLA2) mRNA and protein expression, promoter activity, and prostaglandin E2 secretion in human lung epithelial cells. [Am J Physiol Lung Cell Mol Physiol] Abstract

Amiloride-Sensitive Fluid Resorption in NCI-H441 Lung Epithelia Depends on an Apical Cl Conductance
Researchers demonstrated that water resorption depends on epithelial sodium channel (ENaC), and cystic fibrosis transmembrane regulator (CFTR) channels have only a minor but probably modulating effect on water resorption. However, the major ENaC-mediated water resorption depends on an apical non-CFTR Cl conductance. [Physiol Rep] Full Article

Fluticasone Furoate Is More Effective than Mometasone Furoate in Restoring Tobacco Smoke Inhibited SOCS-3 Expression in Airway Epithelial Cells
The authors compared the effect of fluticasone furoate with mometasone furoate on cytokine signaling-3 (SOCS-3) expression in tobacco smoke exposed BAEpCs in vitro and in a mouse model of chronic obstructive pulmonary disease in vivo. [Int Immunopharmacol] Full Article


A Dual Role for Autophagy in a Murine Model of Lung Cancer
Researchers report that tissue-specific inactivation of Atg5, essential for the formation of autophagosomes, markedly impairs the progression of KRasG12D-driven lung cancer, resulting in a significant survival advantage of tumor-bearing mice. [Nat Commun] Abstract

Loss of LKB1 Promotes CXCL8 Production via NF-κB and WNT Signaling in Human Bronchial Epithelial Cells
Investigators utilized human bronchial epithelial cells immortalized in the absence of viral onco-proteins that represent a useful model to study the early events of lung carcinogenesis. [Clin Cancer Res] Abstract

A Multicenter Phase II Study of Sorafenib Monotherapy in Clinically Selected Patients with Advanced Lung Adenocarcinoma after Failure of EGFR-TKI Therapy
The authors investigated the efficacy and safety of sorafenib in patients with advanced lung adenocarcinoma after failure of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) therapy. [Lung Cancer] Abstract

View On-Demand Webinar: Optimized Differentiation of Bronchial Epithelial Cells
Targeting EGFR Signaling in Chronic Lung Disease: Therapeutic Challenges and Opportunities
The authors provide evidence that targeting the epidermal growth factor receptor (EGFR) signaling pathway may represent a novel therapeutic panacea for treating chronic lung disease. [Eur Respir J] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
An Additional $10.5 Million in Federal Research Secured for Lung Cancer
Lung Cancer Alliance announced that an additional $10.5 million for lung cancer research was signed into law by President Barack Obama as part of the FY 2014 Omnibus Appropriations bill. With the approval of this funding, the new total amount of federal research dollars secured to date is nearly $80 million. [Lung Cancer Alliance]
Press Release

Galapagos Receives €2.9 Million IWT Grant for Cystic Fibrosis Research
Galapagos NV announced that it has been awarded a €2.9 million grant from the Flemish agency for Innovation by Science and Technology (IWT) for cystic fibrosis (CF) research. The goal of this 3-year project is to identify and progress multiple promising CF therapies towards pre-clinical candidates. [Galapagos NV] Press Release

Cystic Fibrosis Foundation Honors UB Pediatrics Professor
Drucy S. Borowitz, clinical professor in the Department of Pediatrics in the University at Buffalo (UB) School of Medicine and Biomedical Sciences, has received a major national award for her groundbreaking research from the Cystic Fibrosis Foundation. [University at Buffalo] Press Release

The HUB Foundation for Organoid Technology and STEMCELL Technologies Sign Agreement on the Manufacturing of Cell Culture Media for Organoids
The HUB Foundation for Organoid Technology announced that it has signed a licensing agreement with STEMCELL Technologies Inc. for the manufacturing and worldwide distribution of cell culture media for growing Organoids. [STEMCELL Technologies] Press Release

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Omnibus Bill Gives Nudge to Public Access
Congress took a small step toward expanding a requirement that science agencies make federally funded research papers publicly available in the omnibus spending bill approved. [ScienceInsider] Editorial

U.S. Science Agencies Get Some Relief in 2014 Budget
The ghost of former President George W. Bush permeates the 2014 budget that Congress released. His presence is good news for physical scientists, but less cheery for biomedical researchers, as Congress reserved some of the biggest spending increases for NASA and the Department of Energy. The National Institutes of Health, meanwhile, got a $1 billion increase that is drawing mixed reviews from research advocates. [ScienceInsider] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Lung Science Conference 2014
March 21-23, 2014
Estoril, Portugal

NEW 2014 Thomas L. Petty Aspen Lung Conference
June 4-7, 2014
Parker, United States

Visit our events page to see a complete list of events in the pulmonary cell community.
NEW Postdoctoral Position – Metabolomics of Pulmonary Medicine (Karolinska Institute)

NEW Postdoctoral Fellowship – Respiratory Science and Medicine (European Respiratory Society)

Post Doctoral Fellow – Role of Stem Cells in Chronic Lung Disease (MedImmune)

PhD Position – Grading CIN in the Mammary Gland (European Molecular Biology Laboratory)

Postdoctoral Research Fellow – Lung Development, Injury/Repair and Fibrosis (Mayo Clinic)

Clinical MD – Clinical Development Program for Oncology and Autoimmune Diseases (Immunomedics, Inc.)

Chief Medical Officer – Novel Therapeutics in Oncology and Autoimmune Disease (Immunomedics, Inc.)

Assistant Professor, Associate Professor, Professor – Lung Biology or Pulmonary and Critical Care Diseases (Boston University School of Medicine & Boston Medical Center)

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