Volume 2.49 | Dec 12

Pulmonary Cell News 2.49 December 12, 2013
Pulmonary Cell News
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TOP STORY
Muc5b Is Required for Airway Defense
Researchers showed that mouse Muc5b is required for mucociliary clearance, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc5ac is dispensable. [Nature] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
TGF-ß Directs Trafficking of the Epithelial Sodium Channel ENaC Which Has Implications for Ion and Fluid Transport in Acute Lung Injury
Treatment of alveolar epithelial cells with bronchoalveolar lavage fluids from acute respiratory distress syndrome patients drove ß epithelial sodium channel (ENaC) internalization, which was inhibited by a TGF-ß neutralizing antibody and a Tgfbr1 inhibitor. [Proc Natl Acad Sci USA] Abstract

Aldehyde Dehydrogenase 3A1 Protects Airway Epithelial Cells from Cigarette Smoke-Induced DNA Damage and Cytotoxicity
Aldehyde dehydrogenase 3A1 (ALDH3A1), an ALDH superfamily member, catalyzes the oxidation of reactive aldehydes, highly toxic components of cigarette smoke (CS). Even so, the role of ALDH3A1 in CS-induced cytotoxicity and DNA damage has not been examined. Among all of the ALDH superfamily members, ALDH3A1 mRNA levels showed the greatest induction in response to CS extract (CSE) exposure of primary human bronchial epithelial cells. [Free Radic Biol Med] Abstract

Neutrophils Are Needed for an Effective Immune Response against Pulmonary Rat Coronavirus Infection, but also Contribute to Pathology
Researchers evaluated the role of polymorphonuclear neutrophils (PMN) during a non-fatal pulmonary coronavirus infection in the natural host. Combined with in vitro experiments showing that PMN express cytokines and chemokines in response to rat coronavirus (RCoV)-infected alveolar epithelial cells, findings supported a role for PMN in eliciting an inflammatory response to RCoV infection. [J Gen Virol] Abstract

Caffeine Induces Alveolar Apoptosis in the Hyperoxia-Exposed Developing Mouse Lung
Caffeine treatment increased inflammation and worsened alveolar hypoplasia in hyperoxia exposed newborn mice. These changes were associated with decreased alveolar type II cell numbers, increased cell apoptosis, and decreased expression of A2A receptors. [Pediatr Res] Abstract

LUNG CANCER

Autophagy Facilitates TLR4- and TLR3-Triggered Migration and Invasion of Lung Cancer Cells through the Promotion of TRAF6 Ubiquitination
Researchers showed that autophagy induced by toll-like receptor (TLR)4 or TLR3 activation enhances various cytokine productions through promoting TNF receptor-associated factor 6, E3 ubiquitin protein ligase ubiquitination and thus facilitates migration and invasion of lung cancer cells. [Autophagy] Abstract

Cancer-Derived Mutations in KEAP1 Impair NRF2 Degradation But Not Ubiquitination
Researchers characterized 18 KEAP1 mutations defined in a lung squamous cell carcinoma tumor set. Cell-based and in vitro biochemical analyses demonstrated that despite its inability to suppress NRF2 activity, the R320Q ‘superbinder’ mutant maintained the ability to ubiquitinate NRF2. [Cancer Res] Abstract

Upregulation of the MicroRNA Cluster at the Dlk1-Dio3 Locus in Lung Adenocarcinoma
RNAseq transcriptome analysis of KrasG12D tumors from F1 hybrid mice revealed features specific to tumor samples. 12qF1 RNAs were repressed in cultured KrasG12D tumor cells but reactivated when transplanted in vivo. [Oncogene] Abstract

Stearoyl-CoA Desaturase-1 Is a Key Factor for Lung Cancer-Initiating Cells
Researchers showed both by RNA interference and through the use of a small molecule inhibitor that stearoyl-CoA desaturase is required for lung cancer spheroids propagation both in stable cell lines and in malignant pleural effusions-derived primary tumor cultures. [Cell Death Dis] Full Article

Combination MET Inhibition and Topoisomerase I Inhibition Block Cell Growth of Small Cell Lung Cancer
Scientists investigated the therapeutic potential of combinatorial targeting of MET using SU11274 and topoisomerase (Top)1 using 7-ethyl-10-hydroxycamptothecin. In vitro stimulation of H82 cells revealed HGF-induced nuclear co-localization of p-MET and Top1. [Mol Cancer Ther] Abstract

Human Neural Stem Cells Expressing Carboxyl Esterase Target and Inhibit Tumor Growth of Lung Cancer Brain Metastases
Human neural stem cells expressing rabbit carboxyl esterase, which activates CPT-11, significantly inhibit the growth of A549 human non-small cell lung adenocarcinoma cells in the presence of CPT-11 in vitro and in vivo. [Cancer Gene Ther] Abstract

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REVIEWS
Progress in the Management of Limited-Stage Small Cell Lung Cancer
Approximately 15% of lung cancer cases are of the small cell subtype, but this variant is highly aggressive and is often diagnosed at advanced stages. Future improvements in outcomes will require clarifying the molecular basis for this disease. [Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
INDUSTRY NEWS
Pulmonary Fibrosis Foundation Announces Plans to Establish a Care Center Network and Patient Registry
The Pulmonary Fibrosis Foundation (PFF) announced plans to establish the PFF Care Center Network and the PFF Patient Registry. These initiatives will improve the health and quality of life of patients suffering from pulmonary fibrosis and will help provide critical insights enabling the medical research community to develop more effective therapies. [The Pulmonary Fibrosis Foundation] Press Release

Apollo Medical Holdings and Boehringer Ingelheim to Collaborate On Care of ApolloMed Accountable Care Organization (ACO) Patients with COPD
Apollo Medical Holdings, Inc. and Boehringer Ingelheim Pharmaceuticals, Inc. announced a partnership dedicated to managing the care of ApolloMed ACO patients with chronic obstructive pulmonary disease (COPD). [PR Newswire Association LLC] Press Release

Medimmune and The Johns Hopkins University Announce Five-Year, $6.5 Million Collaboration to Drive Medical Research and Discovery
MedImmune, AstraZeneca’s global biologics research and development arm, and The Johns Hopkins University announced they have entered into a five-year, $6.5 million research collaboration. The joint research projects will focus on MedImmune’s therapeutic areas of interest, including cardiovascular and metabolic disease; oncology; respiratory, inflammation and autoimmunity; infectious disease and neuroscience. [MedImmune, LLC] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Gulf Thoracic 2014
March 13-15, 2014
Dubai, United Arab Emirates

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Pulmonary Research (The Ohio State University College of Pharmacy)

Clinical MD – Clinical Development Program for Oncology and Autoimmune Diseases (Immunomedics, Inc.)

Chief Medical Officer – Novel Therapeutics in Oncology and Autoimmune Disease (Immunomedics, Inc.)

Assistant Professor, Associate Professor, Professor – Lung Biology or Pulmonary and Critical Care Diseases (Boston University School of Medicine & Boston Medical Center)

Associate Scientist II/Scientist I – Respiratory, Autoimmunity and Inflammation Research (MedImmune)

PhD Position – Genetics of Non-Smoker Chronic Obstructive Pulmonary Disorders (Göttingen Center for Molecular Biosciences)

Postdoctoral Researcher – Metabolomics of Pulmonary Medicine (Karolinska Institute)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)


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