Volume 2.46 | Nov 21

Pulmonary Cell News 2.46 November 21, 2013

In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs

TOP STORY Targeting Small Cell Lung Cancer Harboring PIK3CA Mutation with a Selective Oral PI3K Inhibitor PF-4989216 PF-4989216 inhibited PI3K downstream signaling and subsequently led to apoptosis induction, and inhibition in cell viability, transformation, and xenograft tumor growth in small cell lung cancers harboring PIK3CA mutation. [Clin Cancer Res] Abstract   PUBLICATIONS (Ranked by impact factor of the journal) Role of Activin-A in Cigarette Smoke-Induced Inflammation and COPD Researchers studied the effect of cigarette smoke (CS) on primary human bronchial epithelial cells in vitro. Next, activin-A signaling was antagonized in vivo by administration of follistatin in mice exposed to air or CS for 4 weeks. [Eur Respir J] Abstract Early Host Responses of Seasonal and Pandemic Influenza A Viruses in Primary Well-Differentiated Human Lung Epithelial Cells Investigators hypothesized that host responses during infection of well-differentiated, primary human bronchial epithelial cells may differ between seasonal and H1N1 pandemic influenza A virus isolates from a fatal and nonfatal case. [PLoS One] Full Article Autophagy Mediates Avian Influenza H5N1 Pseudotyped Particle-Induced Lung Inflammation through NF-κB and p38 MAPK Signaling Pathways Researchers showed that H5N1 hemagglutinin pseudotyped viral particles significantly induced autophagy both in A549 human lung epithelial cells and in mouse lung tissues, which was primarily due to hemagglutinin of H5N1 virus. [Am J Physiol Lung Cell Mol Physiol] Abstract Characterization of Innate Responses to Influenza Virus Infection in a Novel Lung Type I Epithelial Cell Model Researchers characterized influenza virus replication dynamics and host responses of lung type I epithelial cells and identified the capacity of epithelial cell-derived type I interferon to regulate specific modules of antiviral effectors to establish an effective antiviral state. [J Gen Virol] Abstract LUNG CANCER Ras Regulates Kinesin 13 Family Members to Control Cell Migration Pathways in Transformed Human Bronchial Epithelial Cells Scientists showed that expression of the microtubule depolymerizing kinesin KIF2C is induced by transformation of immortalized human bronchial epithelial cells by expression of K-RasG12V and knockdown of p53. [Oncogene] Abstract A Novel Molecular Pathway for Snail-Dependent, SPARC-Mediated Invasion in Non-Small Cell Lung Cancer Pathogenesis Treatment of human bronchial epithelial cell lines with TGF-β1 and inhibition of TGF-β1 mRNA expression modulated Secreted Protein, Acidic and Rich in Cysteine (SPARC) expression. Inhibition of MEK phosphorylation downregulated SPARC. [Cancer Prev Res] Abstract Epigenetic Regulation of ANKRD18B in Lung Cancer ANKRD18B mRNA expression was significantly decreased or silenced in lung cancer tissues and cell lines associated with hypermethylation of the ANKRD18B region. Demethylation agent 5-aza-2′-deoxycytidine significantly increased ANKRD18B mRNA expression in lung cancer cell lines. [Mol Carcinog] Abstract Diversin Increases the Proliferation and Invasion Ability of Non-Small-Cell Lung Cancer Cells via JNK Pathway Researchers found that Diversin was overexpressed in non-small-cell lung cancer, and exhibited direct correlation to poor differentiation, advanced TNM stage, lymph node metastasis and survival time. [Cancer Lett] Abstract Combination of Liquiritin, Isoliquiritin and Isoliquirigenin Induce Apoptotic Cell Death through Upregulating p53 and p21 in the A549 Non-Small Cell Lung Cancer Cells Scientists evaluated the cytotoxicity and antitumor activity of liquiritin, isoliquiritin and isoliquirigenin on human non-small lung cancer cells including apoptosis-induction, inhibition of apoptotic pathways and to explore the underlying mechanism. [Oncol Rep] Abstract   REVIEWS Targeting IGF-I and IGFBP-3 Signaling Pathways: A Novel Therapeutic Approach for Asthma The authors summarize the role of insulin like growth factor I (IGF-I) and insulin like growth factor binding protein 3 (IGFBP-3) in the context of allergic airway disease and discuss the therapeutic potential of various strategies targeting the IGF-I and IGFBP-3 signaling pathways for the management of asthma. [Am J Respir Cell Mol Biol] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.   INDUSTRY NEWS Novocure Enrolls First Patients in a Randomized Trial of NovoTTF™ Therapy for Patients with Brain Metastases from Non-Small Cell Lung Cancer Novocure announced that the first patients have enrolled in the EF-21 Study, a prospective randomized clinical study of NovoTTF™ Therapy for patients with brain metastases from non-small cell lung carcinoma cancer. [PR Newswire Association LLC] Press Release Cancer Network Presents Special Coverage During Lung Cancer Awareness Month UBM Medica US announces that Cancer Network, the leading online community for oncologist and others who treat cancer, presents special coverage of lung cancer during November. [PR Newswire Association LLC] Press Release Once-Daily Ultibro® Inhalation Capsules (QVA149) for COPD Launched in Japan Sosei Group Corporation confirms that Novartis Pharma K.K. launched once-daily Ultibro® Inhalation Capsules for relief of various symptoms due to airway obstruction in chronic obstructive pulmonary disease (COPD). [Sosei Group Corporation] Press Release From our sponsor: Looking for ALDH+ cancer stem cells? Watch a video to see how ALDEFLUORTM can help.   POLICY NEWS The Bonnie J. Addario Lung Cancer Foundation Proud to Receive Assemblyman Pan Resolution Honoring Its Awareness Efforts The Bonnie J. Addario Lung Cancer Foundation received a Resolution from Assemblyman Richard Pan, honoring its efforts to raise awareness and funding for the nation’s number one cancer killer. [BusinessWire] Press Release National Institutes of Health (United States) Food and Drug Administration (United States) Center for Biologics Evaluation and Research (United States) European Medicines Agency (European Union) Medicines and Healthcare Products Regulatory Agency (United Kingdom) Therapeutic Goods Administration (Australia)   EVENTS NEW Keystone Symposia on Molecular and Cellular Biology: Stem Cells and Cancer February 2-7, 2014 Banff, Canada Visit our events page to see a complete list of events in the pulmonary cell community.   JOB OPPORTUNITIES NEW Postdoctoral Researcher – Metabolomics of Pulmonary Medicine (Karolinska Institute) Research Fellow – Influence of the Lung Microbiome on Host Immune Response to Respiratory Pathogens (Queen’s University Belfast) Postdoctoral Fellow – Respiratory Research (Karolinska Institute) PhD Studentship – Epithelial Surfaces in the Lung (University of East Anglia) Postdoctoral Scientist – Prognostic Biomarkers in Lung Cancer and Mesothelioma (Medical Research Council) Postdoctoral Research Associate – Airway Innate Defense and Biology (University of North Carolina – Chapel Hill) Senior Postdoctoral Fellow – Mechanisms of Lung Injuries (University of Texas Health Science Center at Tyler) Scientist – Particle Chemistry (STEMCELL Technologies Inc.) Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.) Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.) Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.   Have we missed an important article or publication in Pulmonary Cell News? Click here to submit! Comments or Suggestions? Email [email protected] with your feedback.

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